AB101851

Anti-PROX1 antibody - BSA and Azide free

4

(8 리뷰들)

|

(44 제품이 사용된 논문 )

Anti-PROX1 antibody - BSA and Azide free (ab101851) is a rabbit polyclonal antibody provided in a PBS only buffer for easy conjugation detecting PROX1 in IHC-Fr. Suitable for Mouse.

- BSA, sodium azide, and glycerol-free for easy conjugation
- Over 30 publications
- Trusted since 2010

대체 명칭 보기

Prospero homeobox protein 1, Homeobox prospero-like protein PROX1, PROX-1, PROX1

1 이미지

Immunohistochemistry (Frozen sections) - Anti-PROX1 antibody - BSA and Azide free (AB101851)

IHC-Fr

Supplier Data

Immunohistochemistry (Frozen sections) - Anti-PROX1 antibody - BSA and Azide free (AB101851)

Immunohistochemistry (Frozen sections) analysis of mouse embryo (day 13.5) tissue sections labelling PROX1 (red) with ab101851. Green - CD31, lv - large vessel, arrows - blood vessels, sg - sympathetic ganglion.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Mouse

Applications

IHC-Fr

Immunogen

Recombinant Fragment Protein within Human PROX1 aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

style

left-column

대체품

Primary Antibodies

AB199359

Anti-PROX1 antibody [EPR19273]

RabMAb|Advanced Validation|Recombinant|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-PROX1 antibody [EPR19273] (AB199359)

4
7

Primary Antibodies

AB124910

Anti-PROX1 antibody [EPR3128(2)]

20ul selling size|RabMAb|Recombinant

Western blot - Anti-PROX1 antibody [EPR3128(2)] (AB124910)

5
1

Primary Antibodies

AB236026

Anti-PROX1 antibody [EPR19273] - BSA and Azide free

RabMAb|Advanced Validation|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-PROX1 antibody [EPR19273] - BSA and Azide free (AB236026)

0
0

Primary Antibodies

AB33219

Anti-PROX1 antibody [5G10]

Trial Size

Western blot - Anti-PROX1 antibody [5G10] (AB33219)

3
5

Primary Antibodies

AB38692

Anti-PROX1 antibody

Western blot - Anti-PROX1 antibody (AB38692)

3
8

Primary Antibodies

AB225414

Alexa Fluor® 647 Anti-PROX1 antibody [EPR19273]

RabMAb|Recombinant

Immunohistochemistry (Frozen sections) - Alexa Fluor® 647 Anti-PROX1 antibody [EPR19273] (AB225414)

3
4

보완 제품

Primary Antibodies

AB33682

Anti-LYVE1 antibody

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYVE1 antibody (AB33682)

4
15

Primary Antibodies

AB183734

Anti-GFP antibody [EPR14104]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFP antibody [EPR14104] (AB183734)

5
24

Primary Antibodies

AB16667

Anti-Ki67 antibody [SP6]

BOND RX™ Validated|KO Validated|RabMAb|Advanced Validation|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody [SP6] (AB16667)

5
133

Primary Antibodies

AB207175

Anti-Doublecortin antibody [EPR19997]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Doublecortin antibody [EPR19997] (AB207175)

3
3

style

left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }

style

left-column

제품 세부 정보

What is this antibody validated in?
Anti-PROX1 antibody - BSA and Azide free (ab101851) is a rabbit polyclonal antibody and is validated for use in Immunohistochemistry (IHC-Fr) in Mouse samples.

Trusted by the scientific community
Anti-PROX1 - BSA and Azide free (ab101851) was first used in a scientific publication in 2010 and has been cited over 30 times in peer-reviewed journals.

Reviewed by scientists
Anti-PROX1 - BSA and Azide free (ab101851) has over 5 independent reviews from customers.

style

left-column

특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

보관 버퍼

Constituents: PBS

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

style

left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The PROX1 protein also known as Prospero homeobox 1 acts mechanically as a transcription factor and plays an important role in cell differentiation. Its molecular mass is about 83 kilodaltons. This protein is expressed in a range of tissues including the liver heart and lymphatic system. During embryonic development PROX1 is notably active where it participates in organogenesis and differentiation into specific cell types.

Biological function summary

PROX1 influences numerous processes by regulating gene expression. It forms part of several protein complexes that determine the fate of lymphatic endothelial cells balancing between lymphatic and blood vascular destinies. PROX1 directly affects the promotion and maintenance of the lymphatic endothelial cell phenotype. Its activity is fundamental to the development and maintenance of several organs and tissues impacting overall physiological function.

Pathways

The transcription factor PROX1 integrates into the VEGF signaling pathway and the Wnt signaling pathway. Within these pathways it interacts closely with other proteins such as VEGF-C and Β-catenin. PROX1 modulates these pathways to orchestrate cell proliferation migration and vessel formation. Through its interactions PROX1 significantly contributes to the intricate communication between cells in developing tissues.

Research indicates that dysregulation of PROX1 is linked to cancer and lymphatic diseases. In cancer particularly colorectal and breast cancers aberrant PROX1 expression can promote tumor progression. It interacts with proteins like NF-κB which influence inflammatory responses and cell survival. Similarly in lymphedema altered PROX1 can disrupt normal lymphatic development affecting fluid balance and immune function in the body.

style

left-column

style

left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

타겟 정보

Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses : transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components : BMAL1, NPAS2 and CRY1 and metabolic genes : AVPR1A and ELOVL3.

See full target information PROX1

style

left-column

제품이 사용된 논문 (44)

Recent publications for all applications. Explore the 전체 목록 and refine your search

The Journal of experimental medicine 222: PubMed40505102

2025

Intestinal lymphatic vasculature is functionally adapted to different drainage regions and is altered by helminth infection.

Applications

Unspecified application

Species

Unspecified reactive species

Jorden I Lane,Elida Nieves-Ortiz,Ornella Ndatabaye,Aliia R Fatkhullina,Sebastian Lopez,Terence S Dermody,Daria Esterházy

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 12:e2406849 PubMed39556706

2024

Deficiency of FABP7 Triggers Premature Neural Differentiation in Idiopathic Normocephalic Autism Organoids.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao Han,Yuanlin He,Yuanhao Wang,Wenzhu Hu,Chu Chu,Lei Huang,Yuan Hong,Lu Han,Xu Zhang,Yao Gao,Yuan Lin,Hongxia Ma,Hongbing Shen,Xiaoyan Ke,Yan Liu,Zhibin Hu

PloS one 19:e0302926 PubMed38718095

2024

Zmiz1 is a novel regulator of lymphatic endothelial cell gene expression and function.

Applications

Unspecified application

Species

Unspecified reactive species

Rajan K C,Nehal R Patel,Anoushka Shenoy,Joshua P Scallan,Mark Y Chiang,Maria J Galazo,Stryder M Meadows

Journal of respiratory biology and translational medicine 1: PubMed38529320

2024

Single Cell Analysis of Lung Lymphatic Endothelial Cells and Lymphatic Responses during Influenza Infection.

Applications

Unspecified application

Species

Unspecified reactive species

Jian Ge,Hongxia Shao,Hongxu Ding,Yuefeng Huang,Xuebing Wu,Jie Sun,Jianwen Que

Biomaterials research 28:0011 PubMed38500782

2024

Improved Neural Inductivity of Size-Controlled 3D Human Embryonic Stem Cells Using Magnetic Nanoparticles.

Applications

Unspecified application

Species

Unspecified reactive species

Boram Son,Sora Park,Sungwoo Cho,Jeong Ah Kim,Seung-Ho Baek,Ki Hyun Yoo,Dongoh Han,Jinmyoung Joo,Hee Ho Park,Tai Hyun Park

Frontiers of optoelectronics 16:45 PubMed38095816

2023

Photostimulation of lymphatic clearance of β-amyloid from mouse brain: a new strategy for the therapy of Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Dongyu Li,Hao Lin,Silin Sun,Shaojun Liu,Zhang Liu,Yuening He,Jingtan Zhu,Jianyi Xu,Oxana Semyachkina-Glushkovskaya,Tingting Yu,Dan Zhu

Communications biology 6:1239 PubMed38066234

2023

Transcranial photobiomodulation improves insulin therapy in diabetic microglial reactivity and the brain drainage system.

Applications

Unspecified application

Species

Unspecified reactive species

Shaojun Liu,Dongyu Li,Tingting Yu,Jingtan Zhu,Oxana Semyachkina-Glushkovskaya,Dan Zhu

Cellular and molecular bioengineering 16:325-339 PubMed37811004

2023

A 3D Human Lymphatic Vessel-on-Chip Reveals the Roles of Interstitial Flow and VEGF-A/C for Lymphatic Sprouting and Discontinuous Junction Formation.

Applications

Unspecified application

Species

Unspecified reactive species

Isabelle S Ilan,Aria R Yslas,Yansong Peng,Renhao Lu,Esak Lee

NPJ Regenerative medicine 8:41 PubMed37537178

2023

Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms.

Applications

Unspecified application

Species

Unspecified reactive species

Xiuxiu Liu,Maoying Han,Wendong Weng,Yan Li,Wenjuan Pu,Kuo Liu,Xufeng Li,Lingjuan He,Ruilin Sun,Ruling Shen,Yulong He,Dandan Liang,Yi-Han Chen,Qing-Dong Wang,Jan S Tchorz,Bin Zhou

Annals of the New York Academy of Sciences 1527:60-74 PubMed37531162

2023

REG1A protects retinal photoreceptors from blue light damage.

Applications

Unspecified application

Species

Unspecified reactive species

Ze-Hua Xu,Hang Zhang,Chang-Jun Zhang,Si-Jian Yu,Jing Yuan,Kangxin Jin,Zi-Bing Jin

제품이 사용된 논문 모두 보기

style

left-column

style

left-column

style

right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com