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AB167341

Anti-PSMB5/MB1 antibody

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(5 제품이 사용된 논문 )

Mouse Polyclonal PSMB5/MB1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PSMB5.

대체 명칭 보기

LMPX, MB1, X, PSMB5, Proteasome subunit beta type-5, Macropain epsilon chain, Multicatalytic endopeptidase complex epsilon chain, Proteasome chain 6, Proteasome epsilon chain, Proteasome subunit MB1, Proteasome subunit X, Proteasome subunit beta-5, beta-5

1 이미지
Immunocytochemistry/ Immunofluorescence - Anti-PSMB5/MB1 antibody (AB167341)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-PSMB5/MB1 antibody (AB167341)

Immunofluorescent analysis of HeLa cells labeling PSMB5/MB1 with ab167341 at 10 μg/ml.

주요 정보

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human PSMB5.

P28074

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대체품

Primary Antibodies

AB3330

Anti-PSMB5/MB1 antibody

Immunocytochemistry - Anti-PSMB5/MB1 antibody (AB3330)

  • 5
  • 4

보완 제품

Primary Antibodies

AB155091

Anti-PSME1 antibody [EPR10967(B)]

RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-PSME1 antibody [EPR10967(B)] (AB155091)

  • 5
  • 4
Primary Antibodies

AB166628

Anti-Proteasome subunit beta type 2/PSMB2 antibody [EPR8826(2)(B)]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Proteasome subunit beta type 2/PSMB2 antibody [EPR8826(2)(B)] (AB166628)

  • 4
  • 5
Reagents, Controls & Accessories

AB7481

Normal Goat Serum

Immunohistochemistry (Frozen sections) - Normal Goat Serum (AB7481)

  • 5
  • 3
Primary Antibodies

AB207305

Anti-SQSTM1 / p62 antibody [EPR18351] - Autophagosome Marker

20ul selling size|KO Validated|RabMAb|Recombinant|Lab Essentials|Trial Size

Immunocytochemistry/ Immunofluorescence - Anti-SQSTM1 / p62 antibody [EPR18351] - Autophagosome Marker (AB207305)

  • 5
  • 3
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
pH: 7.4 Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

PSMB5 also known as MB1 or β5 is a subunit of the 20S proteasome complex with a molecular mass of approximately 28 kDa. This protein functions as a chymotrypsin-like peptidase that is important for protein degradation. It is expressed in various tissues throughout the body particularly in those with high protein turnover.
Biological function summary

PSMB5 plays a significant role in regulating protein homeostasis within the cell. It forms part of the core 20S proteasome complex where its enzymatic activity facilitates the breakdown of ubiquitinated proteins into smaller peptides. This protein degradation is essential for many cellular processes including the removal of damaged or misfolded proteins therefore maintaining cellular function.

Pathways

PSMB5 is integral to the ubiquitin-proteasome pathway which is important for protein recycling and quality control within cells. This pathway involves the tagging of proteins with ubiquitin and their subsequent degradation by the proteasome. PSMB5 interacts with other proteasome subunits like β1 and β2 contributing to a functional protein breakdown machinery. Dysregulation of this pathway can lead to the accumulation of unwanted proteins and affect cellular health.

Alterations in PSMB5 function have been implicated in the development of cancer and neurodegenerative diseases. Cancer cells often exhibit altered proteasome activity where PSMB5 may contribute to the survival and proliferation of these cells. In neurodegenerative diseases like Alzheimer's impairments in protein degradation pathways including PSMB5 can lead to protein aggregation and toxicity. Researchers are exploring how PSMB5 interacts with other proteins within these contexts to better understand its potential as a therapeutic target.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.
See full target information PSMB5
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제품이 사용된 논문 (5)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of cellular and molecular medicine 26:5078-5094 PubMed36071546

2022

ISGylation of EMD promotes its interaction with PDHA to inhibit aerobic oxidation in lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Congcong Zhang,Jiangtao Cui,Leiqun Cao,Xiaoting Tian,Yayou Miao,Yikun Wang,Shiyu Qiu,Wanxin Guo,Lifang Ma,Jinjing Xia,Xiao Zhang

Cell death discovery 8:59 PubMed35149670

2022

YAP ISGylation increases its stability and promotes its positive regulation on PPP by stimulating 6PGL transcription.

Applications

Unspecified application

Species

Unspecified reactive species

Xiangfei Xue,Xiaoting Tian,Congcong Zhang,Yayou Miao,Yikun Wang,Yingxiu Peng,Shiyu Qiu,Hong Wang,Jiangtao Cui,Leiqun Cao,Fenyong Sun,Yongxia Qiao,Xiao Zhang

FEBS letters 595:2522-2532 PubMed34418081

2021

Azurocidin is loaded into small extracellular vesicles via its N-linked glycosylation and promotes intravasation of renal cell carcinoma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Takuya Naito,Kentaro Jingushi,Koji Ueda,Kazutake Tsujikawa

Cell death & disease 12:42 PubMed33414446

2021

TRIB2 modulates proteasome function to reduce ubiquitin stability and protect liver cancer cells against oxidative stress.

Applications

Unspecified application

Species

Unspecified reactive species

Susu Guo,Yuxin Chen,Yueyue Yang,Xiao Zhang,Lifang Ma,Xiangfei Xue,Yongxia Qiao,Jiayi Wang

Cancer cell international 20:587 PubMed33372599

2020

RRM2 protects against ferroptosis and is a tumor biomarker for liver cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yueyue Yang,Jiafei Lin,Susu Guo,Xiangfei Xue,Yikun Wang,Shiyu Qiu,Jiangtao Cui,Lifang Ma,Xiao Zhang,Jiayi Wang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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