JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB224392

Anti-PTGFRN antibody

Be the first to review this product! 리뷰 제출

|

(1 출판물)

Rabbit Polyclonal PTGFRN antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PTGFRN aa 350-500.

대체 명칭 보기

CD315, CD9P1, EWIF, FPRP, KIAA1436, PTGFRN, Prostaglandin F2 receptor negative regulator, CD9 partner 1, Glu-Trp-Ile EWI motif-containing protein F, Prostaglandin F2-alpha receptor regulatory protein, Prostaglandin F2-alpha receptor-associated protein, CD9P-1, EWI-F

3 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTGFRN antibody (AB224392)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTGFRN antibody (AB224392)

Immunohistochemical analysis of human endometrium tissue labeling PTGFRN with ab224392 at 1/20 dilution. Strong membranous positivity in glandular cells.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTGFRN antibody (AB224392)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTGFRN antibody (AB224392)

Immunohistochemical analysis of human prostate tissue labeling PTGFRN with ab224392 at 1/20 dilution. Strong membranous positivity in glandular cells.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTGFRN antibody (AB224392)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTGFRN antibody (AB224392)

Immunohistochemical analysis of human endometrium tissue labeling PTGFRN with ab224392 at 1/20 dilution. Moderate membranous and cytoplasmic positivity in glandular cells.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PTGFRN aa 350-500. The exact immunogen used to generate this antibody is proprietary information.

Q9P2B2

style
left-column

대체품

Primary Antibodies

AB97567

Anti-PTGFRN antibody

Immunocytochemistry/ Immunofluorescence - Anti-PTGFRN antibody (AB97567)

  • 1
  • 1

보완 제품

Primary Antibodies

AB188813

Anti-SLITRK6 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLITRK6 antibody (AB188813)

  • 0
  • 0
Primary Antibodies

AB73254

Anti-Eph receptor A2 antibody [RM-0051-8F21]

Flow Cytometry - Anti-Eph receptor A2 antibody [RM-0051-8F21] (AB73254)

  • 4
  • 8
Primary Antibodies

AB214488

Anti-TROP2 antibody [EPR20043]

20ul selling size|BOND RX™ Validated|KO Validated|RabMAb|Recombinant

Western blot - Anti-TROP2 antibody [EPR20043] (AB214488)

  • 5
  • 9
Primary Antibodies

AB227695

Anti-GPNMB antibody [SP299]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-GPNMB antibody [SP299] (AB227695)

  • 0
  • 0
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

PTGFRN also known as Prostaglandin F2 receptor negative regulator is a membrane protein with a mass of approximately 94 kDa. This protein is expressed on various cell types including immune cells like monocytes and macrophages as well as in the heart and lung tissues. PTGFRN interacts with other membrane proteins to modify signalling pathways particularly those involving G-protein-coupled receptors.
Biological function summary

PTGFRN modulates prostaglandin-mediated signaling serving as a regulatory component that dampens the response to prostaglandin F2 alpha. It is part of a multi-protein complex which includes interactions with proteins like CD9 and integrins. These interactions influence cell adhesion and mobility making PTGFRN relevant in processes like inflammation and tissue repair.

Pathways

PTGFRN plays a significant role in the prostaglandin signaling cascade affecting signal transduction linked with inflammatory responses. It is closely associated with the PI3K/Akt pathway a critical pathway for cellular survival and proliferation. The interactions between PTGFRN and CD9 or integrins facilitate the integration of signals that modify cell growth and immune function.

PTGFRN has been implicated in heart failure and inflammatory lung diseases like chronic obstructive pulmonary disease (COPD). In heart failure PTGFRN can interact with integrins to influence cardiac remodeling and fibrosis. In COPD its regulatory function within the prostaglandin pathway affects inflammatory responses. Understanding these interactions provides insights into potential therapeutic targets for managing these conditions.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity). In myoblasts, associates with tetraspanins CD9 and CD81 to prevent myotube fusion during muscle regeneration (By similarity).
See full target information PTGFRN
style
left-column

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nature communications 15:6365 PubMed39075094

2024

Cell fate decision by a morphogen-transcription factor-chromatin modifier axis.

Applications

Unspecified application

Species

Unspecified reactive species

Jin Ming,Lihui Lin,Jiajun Li,Linlin Wu,Shicai Fang,Tao Huang,Yu Fu,Dong Liu,Wenhui Zhang,Chen Li,Yongzheng Yang,Yi Huang,Yue Qin,Junqi Kuang,Xingnan Huang,Liman Guo,Xiaofei Zhang,Jing Liu,Jiekai Chen,Chengchen Zhao,Bo Wang,Duanqing Pei
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com