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AB230300

Anti-PTPN18 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal PTPN18 antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PTPN18 aa 1-250.

대체 명칭 보기

BDP1, PTPN18, Tyrosine-protein phosphatase non-receptor type 18, Brain-derived phosphatase

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTPN18 antibody (AB230300)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTPN18 antibody (AB230300)

Paraffin-embedded human brain tissue stained for PTPN18 with ab230300 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PTPN18 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

Q99952

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보완 제품

Primary Antibodies

AB179483

Anti-HIF-1 alpha antibody [EPR16897]

20ul selling size|RabMAb|Advanced Validation|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-HIF-1 alpha antibody [EPR16897] (AB179483)

  • 4
  • 9
Primary Antibodies

AB216341

Anti-Nephrin antibody [EPR20993]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nephrin antibody [EPR20993] (AB216341)

  • 4
  • 1
Primary Antibodies

AB169755

Anti-5 Lipoxygenase/5-LO antibody [EP6072(2)]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-5 Lipoxygenase/5-LO antibody [EP6072(2)] (AB169755)

  • 5
  • 1
Primary Antibodies

AB225924

Anti-ZNF169 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF169 antibody (AB225924)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

PTPN18 also known as protein tyrosine phosphatase non-receptor type 18 or BDP1 functions as a tyrosine phosphatase enzyme involved in signaling pathways by removing phosphate groups from tyrosine residues on proteins. This protein has a molecular mass of approximately 48 kDa. It is expressed in various tissues with particular presence in the brain liver and skeletal muscle. By modulating phosphorylation states PTPN18 plays a vital role in cellular signal transduction.
Biological function summary

PTPN18 influences cellular processes such as growth differentiation and apoptosis by regulating phosphorylation events. This enzyme acts in concert with other signaling molecules although it does not form specific complexes itself. PTPN18 interacts with substrates like the HER2/ERBB2 receptor impacting critical pathways regulating cell proliferation and survival. These interactions allow PTPN18 to exert control over cellular responses helping maintain homeostasis within biological systems.

Pathways

PTPN18 is an important modulator within the ERK/MAPK and PI3K/Akt signaling cascades. Within the ERK/MAPK pathway PTPN18 interacts with proteins such as SHC1 and GRB2 to help regulate cellular activities like division and differentiation. In the PI3K/Akt pathway PTPN18 affects cell survival and metabolism by regulating components in the signaling cascade. These interactions establish PTPN18 as a critical player in transmitting extracellular signals to the intracellular machinery.

PTPN18 has connections to cancer and metabolic disorders. It is implicated in the progression and prognosis of certain cancers including breast cancer where it modulates the activity of the ERBB2 receptor. By influencing phosphorylation PTPN18 can impact tumor growth and response to treatment. Additionally alterations in PTPN18 activity may contribute to metabolic diseases through its effects on receptor signaling and cellular metabolism. Understanding these interactions highlights PTPN18's relevance in disease mechanisms and the potential for therapeutic interventions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.
See full target information PTPN18
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell & bioscience 14:88 PubMed38956702

2024

NOX4-mediated astrocyte ferroptosis in Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Yasenjiang Maimaiti,Ting Su,Zhanying Zhang,Lingling Ma,Yuan Zhang,Hong Xu

Histology and histopathology 40:215-223 PubMed38855855

2024

Mechanism of PTPN18 for regulating the migration and invasion of endometrial cancer cells via the MYC/PI3K/AKT pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Shiqi Suo,Song Chen,Liyuan Zhou,Ruili Xu,Jingxia Li,Wei Li
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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