AB233806

Anti-PTPRD antibody [5H5D7]

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(4 제품이 사용된 논문 )

Mouse Monoclonal PTPRD antibody. Suitable for Flow Cyt, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Receptor-type tyrosine-protein phosphatase delta aa 1050 to C-terminus.

대체 명칭 보기

Receptor-type tyrosine-protein phosphatase delta, Protein-tyrosine phosphatase delta, R-PTP-delta, PTPRD

3 이미지

Flow Cytometry - Anti-PTPRD antibody [5H5D7] (AB233806)

Flow Cyt

Supplier Data

Flow Cytometry - Anti-PTPRD antibody [5H5D7] (AB233806)

Flow cytometric analysis of HL-60 (human promyelocytic leukemia cell line) cells labeling PTPRD using ab233806 at 1/200 dilution (green) and a negative control (red).

Supplier Data

Western blot - Anti-PTPRD antibody [5H5D7] (AB233806)

Expected MW is 47.4 kDa.

All lanes:

Western blot - Anti-PTPRD antibody [5H5D7] (ab233806) at 1/500 dilution

All lanes:

Human PTPRD (AA: extra 1077-1265) recombinant protein.

Predicted band size: 215 kDa

false

Supplier Data

Western blot - Anti-PTPRD antibody [5H5D7] (AB233806)

All lanes:

Western blot - Anti-PTPRD antibody [5H5D7] (ab233806) at 1/500 dilution

Lane 1:

HEK-293 (human epithelial cell line from embryonic kidney) cell lysate.

Lane 2:

PTPRD (AA: extra 1077-1265)-hIgGFc transfected HEK-293 cell lysate.

Predicted band size: 215 kDa

false

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

5H5D7

Isotype

IgG1

Carrier free

Reacts with

Human

Applications

Flow Cyt, WB

applications

Immunogen

Recombinant Fragment Protein within Human Receptor-type tyrosine-protein phosphatase delta aa 1050 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P23468

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/200 - 1/400", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein G

Purification 관련 사항

Purified from tissue culture supernatant.

보관 버퍼

Preservative: 0.05% Sodium azide Constituents: PBS

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

PTPRD also called Protein Tyrosine Phosphatase Receptor Type D functions as a receptor-type protein tyrosine phosphatase. It is an enzyme that removes phosphate groups from tyrosine residues in proteins. This protein has a mass of about 215 kDa and consists of extracellular transmembrane and intracellular regions. It is expressed broadly in human tissues notably in the nervous system and is present in neurons.

Biological function summary

This protein plays a significant role in cell adhesion and signal transduction. It is important for neuronal development as it helps form synaptic connections influencing the communication between neurons. PTPRD forms part of the protein complex involved in cellular signaling pathways regulating processes such as axon guidance and neural patterning. The extracellular regions which interact with cell surface proteins aid in these functions.

Pathways

PTPRD engages in neurodevelopmental and synaptic signaling pathways. It interacts with proteins like LAR (Leukocyte antigen-related) and N-cadherin both involved in neural development. PTPRD’s phosphatase activity alters the phosphorylation status of downstream components integrating into pathways that are critical for neural network formation and function.

PTPRD has been linked to cancer and neurological disorders such as autism spectrum disorder (ASD). Genetic studies have identified that disruptions in the PTPRD gene are associated with increased cancer risk possibly due to its role in cell growth regulation. In neurological contexts PTPRD effects on synaptic connections suggest a connection with ASD where dysfunctions in neural connectivity are common. It shares a pathway relationship with proteins like contactin and TAG-1 which are also implicated in neural development anomalies.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2.

See full target information Receptor-type tyrosine-protein phosphatase delta

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제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecular cell 82:2779-2796.e10 PubMed35675814

2022

AKT constitutes a signal-promoted alternative exon-junction complex that regulates nonsense-mediated mRNA decay.

Applications

Unspecified application

Species

Unspecified reactive species

Hana Cho,Elizabeth T Abshire,Maximilian W Popp,Christoph Pröschel,Joshua L Schwartz,Gene W Yeo,Lynne E Maquat

Nature communications 12:1848 PubMed33758193

2021

Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Tomoyuki Yoshida,Atsushi Yamagata,Ayako Imai,Juhyon Kim,Hironori Izumi,Shogo Nakashima,Tomoko Shiroshima,Asami Maeda,Shiho Iwasawa-Okamoto,Kenji Azechi,Fumina Osaka,Takashi Saitoh,Katsumi Maenaka,Takashi Shimada,Yuko Fukata,Masaki Fukata,Jumpei Matsumoto,Hisao Nishijo,Keizo Takao,Shinji Tanaka,Shigeo Okabe,Katsuhiko Tabuchi,Takeshi Uemura,Masayoshi Mishina,Hisashi Mori,Shuya Fukai

International journal of clinical and experimental pathology 12:4222-4231 PubMed31933822

2019

miR-516a-3p promotes proliferation, migration, and invasion and inhibits apoptosis in lung adenocarcinoma by targeting PTPRD.

Applications

Unspecified application

Species

Unspecified reactive species

Anhao Wu,Xin Yang,Bing Zhang,Shuting Wang,Gaofeng Li

Kidney international 81:458-68 PubMed22166849

2011

Functional metabotropic glutamate receptors 1 and 5 are expressed in murine podocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Leyi Gu,Xinyue Liang,Lihua Wang,Yucheng Yan,Zhaohui Ni,Huili Dai,Jiayuan Gao,Shan Mou,Qin Wang,Xinyu Chen,Liming Wang,Jiaqi Qian

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PTPRD antibody [5H5D7]

Flow Cytometry - Anti-PTPRD antibody [5H5D7] (AB233806)

Western blot - Anti-PTPRD antibody [5H5D7] (AB233806)

Western blot - Anti-PTPRD antibody [5H5D7] (AB233806)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (4)

Product promise