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AB118336

Anti-PXR antibody

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(5 제품이 사용된 논문 )

Mouse Polyclonal PXR antibody. Suitable for WB, ICC/IF and reacts with Rat, Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NR1I2.

대체 명칭 보기

PXR, NR1I2, Nuclear receptor subfamily 1 group I member 2, Orphan nuclear receptor PAR1, Orphan nuclear receptor PXR, Pregnane X receptor, Steroid and xenobiotic receptor, SXR

1 이미지
Immunocytochemistry/ Immunofluorescence - Anti-PXR antibody (AB118336)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-PXR antibody (AB118336)

ab118336 at 10 μg/ml dilution staining PXR in HepG2 cells by Immunofluorescence.

주요 정보

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human NR1I2.

O75469

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대체품

Primary Antibodies

AB192579

Anti-PXR antibody

Western blot - Anti-PXR antibody (AB192579)

  • 3
  • 5
Primary Antibodies

AB217375

Anti-PXR antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PXR antibody (AB217375)

  • 0
  • 0

보완 제품

Primary Antibodies

AB186869

Anti-Constitutive androstane receptor antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Constitutive androstane receptor antibody (AB186869)

  • 3
  • 2
Primary Antibodies

AB3572

Anti-Cytochrome P450 3A4/CYP3A4 antibody

Western blot - Anti-Cytochrome P450 3A4/CYP3A4 antibody (AB3572)

  • 0
  • 0
Reagents, Controls & Accessories

AB110413

Total OXPHOS Rodent WB Antibody Cocktail

Western blot - Total OXPHOS Rodent WB Antibody Cocktail (AB110413)

  • 5
  • 18
Secondary Antibodies

AB205719

Goat Anti-Mouse IgG H&L (HRP)

Western blot - Goat Anti-Mouse IgG H&L (HRP) (AB205719)

  • 5
  • 4
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
pH: 7.4 Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

PXR also known as the pregnane X receptor or NR1I2 is a nuclear receptor involved in the regulation of gene expression. It plays a significant role in detoxification processes. PXR has a molecular mass of approximately 49 kDa. This receptor is primarily expressed in the liver and intestine where it mediates the induction of enzymes important in metabolizing xenobiotics and endobiotics. Notably PXR activation leads to the expression of cytochrome P450 enzymes including CYP3A4 which are essential in drug metabolism.
Biological function summary

The pregnane X receptor is an important sensor in the body's defense system against potentially harmful compounds. PXR forms a heterodimer complex with the retinoid X receptor (RXR) to exert its function. It binds to response elements in the promoter regions of target genes to regulate their transcription. This receptor is highly responsive to a variety of ligands including medications like buy tiagabine and endogenous steroids such as the pregnanolone chemical structure. Ligands binding to PXR result in the transcriptional upregulation of genes involved in several metabolic pathways.

Pathways

The pregnane X receptor has significant roles in the regulation of drug metabolism and disposition pathways. PXR activation leads to the induction of detoxifying enzymes and transporters prominently within the xenobiotic metabolism pathway. It is closely linked with CYP450 enzymes particularly CYP3A4 and the transport protein MDR1. These proteins work together to increase the metabolism and clearance of a variety of drugs and toxins thereby protecting the organism from potential harm.

PXR is associated with conditions involving drug-induced liver injury and inflammatory bowel disease. Its regulation of CYP3A4 impacts the metabolism of various drugs which can lead to altered efficacy or toxicity as seen in these conditions. Additionally PXR dysregulation has implications in liver diseases where nuclear receptors are critical for maintaining metabolic homeostasis. Interactions between PXR and other nuclear receptors like the constitutive androstane receptor (CAR) further demonstrate its involvement in hepatic health and disease.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Nuclear receptor that acts as a transcription factor regulating genes involved in the metabolism and excretion of xenobiotics, drugs, and endogenous compounds. Activated by a broad range of endogenous steroids (e.g. pregnenolone, progesterone) and xenobiotics, including the antibiotic rifampicin and certain plant-derived metabolites. Upon ligand binding, translocates to the nucleus, forms a heterodimer with the retinoid X receptor/RXR, and binds to response elements in target promoters, leading to transcriptional activation. Target genes include cytochrome P450 enzymes such as CYP3A4 and ATP-binding cassette transporters including ABCB1/MDR1.
See full target information NR1I2
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제품이 사용된 논문 (5)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Chemical & pharmaceutical bulletin 71:334-341 PubMed36858593

2023

Anti-tumor Effect of Gambogenic Acid and Its Effect on CYP2C and CYP3A after Oral Administration.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Sun,Mengdi Pang,Xiaozhu Tang,Qianqian Xu,Daiyin Peng,Weidong Chen

Heliyon 6:e05357 PubMed33163657

2020

PXR is a target of (-)-epicatechin in skeletal muscle.

Applications

Unspecified application

Species

Unspecified reactive species

Miguel Ortiz-Flores,Andrés Portilla-Martínez,Francisco Cabrera-Pérez,Nayelli Nájera,Eduardo Meaney,Francisco Villarreal,Javier Pérez-Durán,Guillermo Ceballos

Molecular medicine reports 20:771-778 PubMed31180561

2019

Effect of copper nanoparticles on brain cytochrome P450 enzymes in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Yanyan Wang,Huaqiao Tang,Min Xu,Jie Luo,Ling Zhao,Fei Shi,Gang Ye,Cheng Lv,Yinglun Li

Biomedical microdevices 20:54 PubMed29946898

2018

Study of melatonin-mediated effects on various hepatic inflammatory responses stimulated by IL-6 in a new HepG2-on-a-chip platform.

Applications

Unspecified application

Species

Unspecified reactive species

Mi Jang,Andreas Manz,Thomas Volk,Astrid Kleber

The Journal of pharmacology and experimental thera 366:332-340 PubMed29891588

2018

Berberine Upregulates P-Glycoprotein in Human Caco-2 Cells and in an Experimental Model of Colitis in the Rat via Activation of Nrf2-Dependent Mechanisms.

Applications

Unspecified application

Species

Unspecified reactive species

Wanghui Jing,Yasaman Safarpour,Ting Zhang,Pengqi Guo,Guoning Chen,Xiaoming Wu,Qiang Fu,Yitao Wang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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