AB228998

Anti-PYROXD2 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal PYROXD2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PYROXD2.

대체 명칭 보기

C10orf33, PYROXD2, Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2

2 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PYROXD2 antibody (AB228998)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PYROXD2 antibody (AB228998)

Paraffin-embedded human breast cancer tissue stained for PYROXD2 using ab228998 at 1/500 dilution in immunohistochemical analysis.

Supplier Data

Western blot - Anti-PYROXD2 antibody (AB228998)

7.5% SDS-PAGE gel.

All lanes:

Western blot - Anti-PYROXD2 antibody (ab228998) at 1/1000 dilution

Lane 1:

HEK-293T (human epithelial cell line from embryonic kidney) whole cell lysate at 30 µg

Lane 2:

Raji (Human Burkitt's lymphoma cell line) whole cell lysate at 30 µg

Predicted band size: 63 kDa

true

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PYROXD2. The exact immunogen used to generate this antibody is proprietary information.

Q8N2H3

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

PYROXD2 also known as Pyridine Nucleotide-Disulfide Oxidoreductase Domain 2 is a protein with a molecular weight of approximately 39 kDa. It functions mechanically as an oxidoreductase enzyme participating in redox reactions by facilitating the transfer of electrons. Expression of PYROXD2 is widespread but shows higher levels in tissues with elevated metabolic activities such as the liver kidney and heart. This widespread expression suggests its fundamental role in cellular processes that require redox homeostasis.

Biological function summary

PYROXD2 contributes to cellular redox balance and detoxification. It operates as part of a larger multi-enzyme complex involved in maintaining oxidative homeostasis in the cell. This function is important for protecting cells against oxidative stress which might lead to cellular damage and apoptosis. By regulating redox-sensitive pathways PYROXD2 helps maintain cellular health and function.

Pathways

PYROXD2 participates in significant biochemical networks focusing on redox regulation and electron transport. Notably the protein interacts within the glutathione metabolic pathway where it works alongside proteins like glutathione peroxidase and glutathione reductase to neutralize reactive oxygen species. PYROXD2 also relates to components of the mitochondrial respiratory chain linking it to important energy-production processes in the cell.

PYROXD2 shows associations with conditions involving oxidative stress including neurodegenerative diseases like Parkinson's Disease. Disrupted redox homeostasis is key in these pathologies where neurons are particularly susceptible to oxidative damage. Additionally PYROXD2 is linked to cardiovascular diseases where oxidative stress contributes to vascular inflammation and damage. These associations point to its potential as a therapeutic target particularly in diseases where oxidative stress plays a critical role.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Probable oxidoreductase that may play a role as regulator of mitochondrial function.

See full target information PYROXD2

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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Immune network 23:e34 PubMed37670811

2023

Tumor Promoting Function of DUSP10 in Non-Small Cell Lung Cancer Is Associated With Tumor-Promoting Cytokines.

Applications

Unspecified application

Species

Unspecified reactive species

Xing Wei,Chin Wen Png,Madhushanee Weerasooriya,Heng Li,Chenchen Zhu,Guiping Chen,Chuan Xu,Yongliang Zhang,Xiaohong Xu

International journal of molecular sciences 23: PubMed35055180

2022

Biallelic Variants in Cause a Severe Infantile Metabolic Disorder Affecting Mitochondrial Function.

Applications

Unspecified application

Species

Unspecified reactive species

Nicole J Van Bergen,Daniella H Hock,Lucy Spencer,Sean Massey,Tegan Stait,Zornitza Stark,Sebastian Lunke,Ain Roesley,Heidi Peters,Joy Yaplito Lee,Anna Le Fevre,Oliver Heath,Cristina Mignone,Joseph Yuan-Mou Yang,Monique M Ryan,Colleen D'Arcy,Margot Nash,Sile Smith,Nikeisha J Caruana,David R Thorburn,David A Stroud,Susan M White,John Christodoulou,Natasha J Brown

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PYROXD2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PYROXD2 antibody (AB228998)

Western blot - Anti-PYROXD2 antibody (AB228998)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (2)

Product promise