AB239607

Anti-RANKL antibody [C1]

(1 리뷰)

(21 제품이 사용된 논문 )

Mouse Monoclonal RANKL antibody. Suitable for WB and reacts with Rat, Recombinant full length protein - Rat samples. Cited in 21 publications. Immunogen corresponding to Recombinant Fragment Protein within Rat Tnfsf11 aa 100-250.

대체 명칭 보기

CD254, Opgl, Rankl, Trance, Tnfsf11, Tumor necrosis factor ligand superfamily member 11, Osteoclast differentiation factor, Osteoprotegerin ligand, Receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine, ODF, OPGL, RANKL, TRANCE

2 이미지

Supplier Data

Western blot - Anti-RANKL antibody [C1] (AB239607)

All lanes:

Western blot - Anti-RANKL antibody [C1] (ab239607) at 5 µg/mL

All lanes:

Rat thymus tissue lysate

Secondary

All lanes:

HRP-Goat Anti-Mouse IgG

Predicted band size: 35 kDa

false

Supplier Data

Western blot - Anti-RANKL antibody [C1] (AB239607)

All lanes:

Western blot - Anti-RANKL antibody [C1] (ab239607) at 5 µg/mL

All lanes:

Recombinant rat RANKL protein

Predicted band size: 35 kDa

false

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

Isotype

IgG2a

Light chain 타입

kappa

Carrier free

Reacts with

Rat

Applications

applications

Immunogen

Recombinant Fragment Protein within Rat Tnfsf11 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.

Q9ESE2

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Recombinant full length protein - Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A/G

Purification 관련 사항

Purified from TCS.

보관 버퍼

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation.

See full target information Tnfsf11

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제품이 사용된 논문 (21)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Scientific reports 15:20701 PubMed40596392

2025

Black tea rich in polygonatum sibiricum polysaccharides inhibits osteoporosis in ovariectomized mice through immune regulation and gut microbiota suppression.

Applications

Unspecified application

Species

Unspecified reactive species

Shiyu Gao,Yikang Yu,Jialu Shu,Biqian Yang,Baiqiao Zhang,Jinhao Xu,Zhenwei Wang

BMC oral health 25:78 PubMed39819670

2025

Investigation of the preventive effect of methylsulfonylmethane on alveolar bone loss and oxidative stress in a rat model of periodontitis.

Applications

Unspecified application

Species

Unspecified reactive species

Melek Beder,Hatice Yemenoglu,Semih Alperen Bostan,Oğuz Kose,Sibel Mataracı Karakas,Tolga Mercantepe,Adnan Yılmaz,Levent Tumkaya

Signal transduction and targeted therapy 8:280 PubMed37500654

2023

Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms.

Applications

Unspecified application

Species

Unspecified reactive species

Na Jia,Yunzhen Gao,Min Li,Yi Liang,Yuwen Li,Yunzhu Lin,Shiqi Huang,Qing Lin,Xun Sun,Qin He,Yuqin Yao,Ben Zhang,Zhirong Zhang,Ling Zhang

Journal of orthopaedic surgery and research 18:234 PubMed36949499

2023

Daytime administration of melatonin has better protective effects on bone loss in ovariectomized rats.

Applications

Unspecified application

Species

Unspecified reactive species

Tian-Lin Li,He-Dong Liu,Mao-Xian Ren,Zhi Zhou,Wen-Kai Jiang,Min Yang

Drug design, development and therapy 17:691-706 PubMed36915642

2023

Integrated Network Pharmacology and Experimental Validation Approach to Investigate the Mechanisms of in the Treatment of Rheumatoid Arthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Wendong Xie,Hua Yang,Chun Guo,Rui Xie,Guoliang Yu,Yifu Li

Life (Basel, Switzerland) 13: PubMed36836664

2023

Secukinumab and Black Garlic Downregulate OPG/RANK/RANKL Axis and Devitalize Myocardial Interstitial Fibrosis Induced by Sunitinib in Experimental Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Hoda E Mohamad,Mervat E Asker,Mohamed A Shaheen,Nourhan M Baraka,Omer I Fantoukh,Abdulaziz Alqahtani,Alaa E Salama,Yasmin K Mahmoud

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10:e2205336 PubMed36581472

2022

Nitric Oxide-Releasing Bioinspired Scaffold for Exquisite Regeneration of Osteoporotic Bone via Regulation of Homeostasis.

Applications

Unspecified application

Species

Unspecified reactive species

Jun-Kyu Lee,Da-Seul Kim,So-Yeon Park,Seung-Woon Baek,Ji-Won Jung,Tae-Hyung Kim,Dong Keun Han

Journal of clinical medicine 12: PubMed36614859

2022

Effect of Mechanical Stimuli and Zoledronic Acid on the Femoral Bone Morphology in Rats with Obesity and Limited Mobility.

Applications

Unspecified application

Species

Unspecified reactive species

Nazar M Kostyshyn,Siemowit Muszyński,Ewa Tomaszewska,Agnieszka Tomczyk-Warunek,Iwona Puzio,Piotr Dobrowolski

Science advances 8:eabp8293 PubMed36525494

2022

In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Akash K Kaushik,Amy Tarangelo,Lindsey K Boroughs,Mukundan Ragavan,Yuanyuan Zhang,Cheng-Yang Wu,Xiangyi Li,Kristen Ahumada,Jui-Chung Chiang,Vanina T Tcheuyap,Faeze Saatchi,Quyen N Do,Cissy Yong,Tracy Rosales,Christina Stevens,Aparna D Rao,Brandon Faubert,Panayotis Pachnis,Lauren G Zacharias,Hieu Vu,Feng Cai,Thomas P Mathews,Giannicola Genovese,Barbara S Slusher,Payal Kapur,Xiankai Sun,Matthew Merritt,James Brugarolas,Ralph J DeBerardinis

Emergency medicine international 2022:1022078 PubMed37008288

2022

Abnormal Variations of the Key Genes in Osteoporotic Fractures.

Applications

Unspecified application

Species

Unspecified reactive species

Bin Wang,Caiyuan Mai,Lei Pan

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-RANKL antibody [C1]

Western blot - Anti-RANKL antibody [C1] (AB239607)

Western blot - Anti-RANKL antibody [C1] (AB239607)

주요 정보

Host species

Clonality

Clone number

Isotype

Light chain 타입

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

보완 제품

Assay Kits

Primary Antibodies

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

제품 프로토콜

타겟 정보

제품이 사용된 논문 (21)

Product promise