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AB192375

Anti-RECQL4 antibody

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(3 제품이 사용된 논문 )

Rabbit Polyclonal RECQL4 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human RECQL4.

대체 명칭 보기

RECQ4, RECQL4, ATP-dependent DNA helicase Q4, DNA 3'-5' helicase RecQ4, RTS, RecQ protein-like 4, RecQ4

1 이미지
Western blot - Anti-RECQL4 antibody (AB192375)
  • WB

Supplier Data

Western blot - Anti-RECQL4 antibody (AB192375)

All lanes:

Western blot - Anti-RECQL4 antibody (ab192375) at 1/500 dilution

Lane 1:

HeLa whole cell lysates.

Lane 2:

NIH-3T3 whole cell lysates.

Lane 3:

Rat brain tissue lysates.

Predicted band size: 133 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human RECQL4. The exact immunogen used to generate this antibody is proprietary information.

O94761

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대체품

Primary Antibodies

AB188125

Anti-RECQL4 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RECQL4 antibody (AB188125)

  • 0
  • 0

보완 제품

Primary Antibodies

AB79398

Anti-RPA70 antibody [EPR3472]

RabMAb|Recombinant|20ul selling size

Flow Cytometry (Intracellular) - Anti-RPA70 antibody [EPR3472] (AB79398)

  • 5
  • 6
Primary Antibodies

AB151501

Anti-RECQ1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RECQ1 antibody (AB151501)

  • 0
  • 0
Primary Antibodies

AB224135

Anti-RECQL5 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RECQL5 antibody (AB224135)

  • 0
  • 0
Primary Antibodies

AB239375

Anti-BRCA2 antibody [EPR23442-43]

20ul selling size|KO Validated|RabMAb|Recombinant

Western blot - Anti-BRCA2 antibody [EPR23442-43] (AB239375)

  • 5
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
Purity is > 95% (by SDS-PAGE).
보관 버퍼
Preservative: 0.1% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

RECQL4 also known as RecQ protein-like 4 is a member of the RecQ helicase family predominantly found in the nucleus. This protein weighs approximately 133 kDa. It functions as a DNA helicase responsible for unwinding DNA strands playing an essential role in DNA replication repair and maintenance. Expression of RECQL4 occurs in various tissues with high levels noted in the testis thymus and fetal tissues. Its involvement in DNA manipulation places it at the center of maintaining genome integrity.
Biological function summary

RECQL4 participates in critical cellular processes. As part of the DNA replication complex it ensures the accurate replication of DNA minimizing errors that could lead to genomic instability. Its role extends to telomere maintenance ensuring that the chromosome ends are preserved during cell division. RECQL4 also contributes to the recovery of stalled replication forks preventing prolonged cell cycle arrest and potential DNA damage. This helicase along with other proteins in the RecQ family acts as a guardian of the genome.

Pathways

RECQL4 participates in the DNA damage response and repair pathways. It interacts with proteins such as ATR an important player in the DNA damage response pathway facilitating cell cycle checkpoints and repair processes. Additionally RECQL4 is involved in telomere maintenance associated with the telomerase pathway in cooperation with TRF1 a telomere-binding protein. These interactions highlight its role in safeguarding genome stability through efficient DNA repair and replication.

Mutations in RECQL4 are linked to Rothmund-Thomson syndrome characterized by skin rash skeletal anomalies and predisposition to cancer. Defects in this protein can also lead to potential association with other genomic instability syndromes. Notably the connection of RECQL4 with p53 a critical regulator of the cell cycle and apoptosis highlights its importance in disease pathways. These associations emphasize the need for proper RECQL4 function for maintaining cellular health and preventing disorder manifestations.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

An ATP-dependent DNA helicase which unwinds dsDNA with a 3'-overhang in a 3'-5' direction (PubMed : 28653661). Does not unwind more than 18 bp of dsDNA (PubMed : 28653661). May modulate chromosome segregation. The N-terminal domain (residues 1-54) binds DNA Y-shaped DNA better than ss- or dsDNA (PubMed : 22730300). The core helicase domain binds ssDNA (PubMed : 22730300, PubMed : 28653661).
See full target information RECQL4
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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

BMC medical genomics 18:38 PubMed40001159

2025

Targeting RECQL4 in hepatocellular carcinoma: from prognosis to therapeutic potential.

Applications

Unspecified application

Species

Unspecified reactive species

Yingchen Li,Linan Yin,Bowen Liu,Yan Liu,Dongfeng He,Xuesong Liu,Ruibao Liu

World journal of surgical oncology 21:231 PubMed37516854

2023

TRIM58 functions as a tumor suppressor in colorectal cancer by promoting RECQL4 ubiquitination to inhibit the AKT signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Naizhi Sun,Jiacheng Shen,Yuhua Shi,Biao Liu,Shengguo Gao,Yichuan Chen,Jinwei Sun

OncoTargets and therapy 12:405-412 PubMed30655677

2019

rs187960998 polymorphism in miR-211 prevents development of human colon cancer by deregulation of 3'UTR in CHD5.

Applications

Unspecified application

Species

Unspecified reactive species

Limei Zhu,Ran Wang,Li Zhang,Chunlei Zuo,Rui Zhang,Shaolin Zhao
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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