JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB242268

redFluor™ 710 Anti-CD19 antibody [1D3]

Be the first to review this product! 리뷰 제출

|

(1 출판물)

Anti-CD19 antibody [1D3] conjugated to redFluor™ 710 - suitable for flow cytometry, and reacts with mouse samples. Clone [1D3] is a rat monoclonal antibody and one of the most commonly used clones for flow cytometry.

Design your panel with our interactive flow cytometry panel builder. Click here.
1 이미지
Flow Cytometry - redFluor™ 710 Anti-CD19 antibody [1D3] (AB242268)
  • Flow Cyt

Supplier Data

Flow Cytometry - redFluor™ 710 Anti-CD19 antibody [1D3] (AB242268)

Flow Cytometric analysis of C57Bl/6 bone marrow cells staining CD19 using 0.125 μg ab242268 (solid line) or 0.125 μg redFluor™ 710 Rat IgG2a isotype control (dashed line).

관련 conjugated 항체와 다양한 조성의 항체 (4)

  • 519 FITC

    FITC Anti-CD19 antibody [1D3]

  • 578 PE

    PE Anti-CD19 antibody [1D3]

  • 778 PE/Cy7®

    PE/Cy7® Anti-CD19 antibody [1D3]

  • 450 violetFluor™ 450

    violetFluor™ 450 Anti-CD19 antibody [1D3]

주요 정보

Host species

Rat

Clonality

Monoclonal

Clone number

1D3

Isotype

IgG2a

Light chain 타입

kappa

Conjugation

redFluor™ 710

Excitation/Emission

Ex: 684nm, Em: 704nm

Carrier free

No

Reacts with

Mouse

Applications

Flow Cyt

applications

Immunogen

Cell preparation containing Cd19 protein. The exact immunogen used to generate this antibody is proprietary information.

P25918

style
left-column

대체품

Primary Antibodies

AB134114

Anti-CD19 antibody [EPR5906]

KO Validated|BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Flow Cytometry (Intracellular) - Anti-CD19 antibody [EPR5906] (AB134114)

  • 4
  • 5
Primary Antibodies

AB195896

HRP Anti-CD19 antibody [EPR5906]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - HRP Anti-CD19 antibody [EPR5906] (AB195896)

  • 0
  • 0
Primary Antibodies

AB196468

Alexa Fluor® 488 Anti-CD19 antibody [EPR5906]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 488 Anti-CD19 antibody [EPR5906] (AB196468)

  • 2
  • 3
Primary Antibodies

AB196515

Alexa Fluor® 647 Anti-CD19 antibody [EPR5906]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 647 Anti-CD19 antibody [EPR5906] (AB196515)

  • 5
  • 1
Primary Antibodies

AB215382

Anti-CD19 antibody [EPR5906] - Low endotoxin, Azide free

KO Validated|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-CD19 antibody [EPR5906] - Low endotoxin, Azide free (AB215382)

  • 0
  • 0
Primary Antibodies

AB225717

Anti-CD19 antibody [SP110] - C-terminal

RabMAb|Recombinant|Lab Essentials|20ul selling size

Flow Cytometry (Intracellular) - Anti-CD19 antibody [SP110] - C-terminal (AB225717)

  • 0
  • 0
Primary Antibodies

AB237772

Anti-CD19 antibody [SP291] - BSA and Azide free

KO Validated|BOND RX™ Validated|Recombinant|Advanced Validation|RabMAb

Flow Cytometry (Intracellular) - Anti-CD19 antibody [SP291] - BSA and Azide free (AB237772)

  • 0
  • 0
Primary Antibodies

AB274888

Alexa Fluor® 555 Anti-CD19 antibody [EPR5906]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 555 Anti-CD19 antibody [EPR5906] (AB274888)

  • 5
  • 1

보완 제품

Primary Antibodies

AB24982

Cy5 ® Anti-CD45.1 antibody [A20]

  • 0
  • 0
Primary Antibodies

AB237365

Alexa Fluor® 647 Anti-CD8 alpha antibody [EPR21769]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 647 Anti-CD8 alpha antibody [EPR21769] (AB237365)

  • 0
  • 0
Primary Antibodies

AB252149

Alexa Fluor® 488 Anti-CD4 antibody [EPR20122]

RabMAb|Recombinant

Flow Cytometry - Alexa Fluor® 488 Anti-CD4 antibody [EPR20122] (AB252149)

  • 0
  • 0
Primary Antibodies

AB307134

Alexa Fluor® 488 Anti-CD3 antibody [SP162]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 488 Anti-CD3 antibody [SP162] (AB307134)

  • 0
  • 0
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p>0.125 μg: We recommend titrating the antibody under your specific conditions to determine the optimal concentration of antibody needed in your experimental system.</p>" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification
Purification 관련 사항
Purified from TCS.
보관 버퍼
pH: 7.2 Preservative: 0.09% Sodium azide Constituents: 0.87% Sodium chloride, 0.12% Sodium dihydrogen phosphate, 0.1% Gelatin
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
보관 정보
Store in the dark
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CD19 is a transmembrane protein also known as B4 or B-lymphocyte antigen CD19 with an approximate molecular weight of 95 kDa. It is expressed on the surface of B cells throughout their development from pro-B cells to mature B cells. CD19 functions mechanically as a coreceptor enhancing the sensitivity of B cell receptor (BCR) signaling. This protein plays a significant role in promoting the activation and proliferation of B cells by lowering the threshold for antigen receptor engagement.
Biological function summary

CD19 acts as an essential player in B cell signaling. CD19 integrates signals from the BCR with other coreceptors acting as a signaling hub. It participates in forming a signaling complex that includes proteins like CD21 and CD81 which further amplifies BCR-mediated signaling. This complex plays a critical role in B cell activation differentiation and survival ensuring that immune responses are efficiently mounted against pathogens.

Pathways

The CD19 protein fits into key immune response pathways such as the BCR signaling pathway and the PI3K-Akt signaling pathway. CD19 collaborates with other proteins like CD21 CD81 and PI3K within these pathways. Its interaction in the PI3K-Akt pathway for instance supports critical processes including B cell activation and homeostasis contributing to the adaptive immune response.

CD19 is connected to B cell malignancies and autoimmune diseases. B cell acute lymphoblastic leukemia (ALL) often shows aberrant CD19 expression making it a valuable target for therapeutic interventions like anti-CD19 monoclonal antibodies. Additionally overexpression or mutations of CD19 may contribute to autoimmune diseases by disrupting normal B cell regulation. CD19's connection with proteins like CD22 and CD20 in these pathological contexts highlights its relevance in developing targeted therapies.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (By similarity). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores (PubMed : 12387743, PubMed : 20101619, PubMed : 9382888). Is not required for early steps during B cell differentiation in the blood marrow (PubMed : 7542548, PubMed : 7543183, PubMed : 9317126). Required for normal differentiation of B-1 cells (PubMed : 12387743, PubMed : 7542548, PubMed : 7543183). Required for normal B cell differentiation and proliferation in response to antigen challenges (PubMed : 12387743, PubMed : 7542548, PubMed : 9317126). Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge (PubMed : 12387743, PubMed : 7542548, PubMed : 7543183).
See full target information Cd19

대체 명칭 보기

CD19, B-lymphocyte antigen CD19, Differentiation antigen CD19, Cd19
style
left-column

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

iScience 27:109439 PubMed38523774

2024

A tetravalent nanovaccine that inhibits growth of HPV-associated head and neck carcinoma via dendritic and T cell activation.

Applications

Unspecified application

Species

Unspecified reactive species

Romano Josi,Daniel E Speiser,Simone de Brot,Anne-Cathrine Vogt,Eva M Sevick-Muraca,Genrich V Tolstonog,Martin F Bachmann,Mona O Mohsen
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com