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AB242077

redFluor™ 710 Anti-CD62L antibody [MEL-14]

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Anti-CD62L antibody [MEL-14] conjugated to redFluor™ 710 - suitable for flow cytometry, and reacts with mouse samples. Clone [MEL-14] is a rat monoclonal antibody and one of the most commonly used clones for flow cytometry.

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Flow Cytometry - redFluor™ 710 Anti-CD62L antibody [MEL-14] (AB242077)
  • Flow Cyt

Supplier Data

Flow Cytometry - redFluor™ 710 Anti-CD62L antibody [MEL-14] (AB242077)

Flow Cytometric analysis of C57Bl/6 splenocytes staining CD62L using 0.5 μg ab242077 (solid line) or 0.5 μg redFluor™ 710 Rat IgG2a isotype control (dashed line).

관련 conjugated 항체와 다양한 조성의 항체 (4)

  • 660 APC

    APC Anti-CD62L antibody [MEL-14]

  • Biotin

    Biotin Anti-CD62L antibody [MEL-14]

  • 519 FITC

    FITC Anti-CD62L antibody [MEL-14]

  • 778 PE/Cy7®

    PE/Cy7® Anti-CD62L antibody [MEL-14]

주요 정보

Host species

Rat

Clonality

Monoclonal

Clone number

MEL-14

Isotype

IgG2a

Light chain 타입

kappa

Conjugation

redFluor™ 710

Excitation/Emission

Ex: 684nm, Em: 704nm

Carrier free

No

Reacts with

Mouse

Applications

Flow Cyt

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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대체품

Primary Antibodies

AB119834

Anti-CD62L antibody [MEL-14]

Recombinant

Flow Cytometry - Anti-CD62L antibody [MEL-14] (AB119834)

  • 0
  • 0
Primary Antibodies

AB218829

Anti-CD62L antibody [EPR22188-297]

RabMAb|Recombinant

Flow Cytometry - Anti-CD62L antibody [EPR22188-297] (AB218829)

  • 0
  • 0
Primary Antibodies

AB245124

Anti-CD62L antibody [EPR22188-297] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry - Anti-CD62L antibody [EPR22188-297] - BSA and Azide free (AB245124)

  • 0
  • 0

보완 제품

Primary Antibodies

AB41459

APC Anti-CD62L antibody [MEL-14]

Flow Cytometry - APC Anti-CD62L antibody [MEL-14] (AB41459)

  • 4
  • 1
Primary Antibodies

AB25569

PE/Cy7® Anti-CD62L antibody [MEL-14]

  • 5
  • 1
Primary Antibodies

AB25064

FITC Anti-CD44 antibody [KM201]

Lab Essentials

Flow Cytometry - FITC Anti-CD44 antibody [KM201] (AB25064)

  • 0
  • 0
Primary Antibodies

AB119834

Anti-CD62L antibody [MEL-14]

Recombinant

Flow Cytometry - Anti-CD62L antibody [MEL-14] (AB119834)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p>0.5 μg: The amount of antibody required for optimal staining of a cell sample should be determined empirically in your system.</p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification
Purification 관련 사항
Purified from TCS.
보관 버퍼
pH: 7.2 Preservative: 0.09% Sodium azide Constituents: 0.87% Sodium chloride, 0.12% Sodium dihydrogen phosphate, 0.1% Gelatin
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
보관 정보
Store in the dark
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CD62L also known as L-selectin is a cell adhesion molecule with a mass of approximately 74 kDa. It is part of the L-selectin family and is found on the surface of leukocytes including T cells B cells neutrophils and monocytes. Mouse models frequently study CD62L under the name "MEL-14". CD62L plays an important role in mediating the adhesion and rolling of leukocytes on blood vessel endothelial cells during the immune response. Its structure allows it to interact specifically with carbohydrates on endothelial cells facilitating the initial steps of leukocyte extravasation into tissues.
Biological function summary

CD62L is involved in the migration of leukocytes into lymphoid tissues and sites of inflammation. It is not known to be part of a larger protein complex; rather it functions independently on the cell membrane. CD62L also assists in the homing of naive lymphocytes to peripheral lymph nodes. The molecule regulates how immune cells enter tissues through high endothelial venules acting as a critical entry point for leukocyte trafficking.

Pathways

CD62L contributes significantly to the immune trafficking pathway and leukocyte adhesion cascade. It works closely with other adhesion molecules like CD44 and CD54 (ICAM-1) which are important within the context of cellular responses during inflammation. CD62L's function in these pathways ensures that immune cells are properly directed to areas where they are needed most whether that is secondary lymphoid organs or inflamed tissues.

CD62L expression and function have been associated with inflammatory conditions and certain immune-related pathologies such as multiple sclerosis and rheumatoid arthritis. Altered CD62L expression can affect lymphocyte homing potentially playing a role in the pathogenesis of these conditions. The role of CD62L is also linked to proteins like CD44 which can modulate cell interactions and have overlapping functions in disease mechanisms influencing disease progression or resolution.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

See full target information CD62L
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Product promise

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