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AB134783

Anti-Renin antibody [7D3-E3]

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(4 제품이 사용된 논문 )

Mouse Monoclonal Renin antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human REN.
1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Renin antibody [7D3-E3] (AB134783)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Renin antibody [7D3-E3] (AB134783)

Immunohistochemical analysis of formalin-fixed, paraffin- embedded Human kidney, tubules tissue labelling Renin with ab134783 at 10μg/ml.

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

7D3-E3

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human REN.

P00797

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대체품

Primary Antibodies

AB212197

Anti-Renin antibody [EPR20693]

Advanced Validation|RabMAb|Recombinant

Multiplex immunohistochemistry - Anti-Renin antibody [EPR20693] (AB212197)

  • 5
  • 8
Primary Antibodies

AB125012

Anti-Renin antibody [EPR6433]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-Renin antibody [EPR6433] (AB125012)

  • 0
  • 0
Primary Antibodies

AB225743

Anti-Renin antibody [EPR20693] - BSA and Azide free

Advanced Validation|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Renin antibody [EPR20693] - BSA and Azide free (AB225743)

  • 1
  • 1

보완 제품

Primary Antibodies

AB108599

Anti-Trefoil Factor 3 antibody [EPR3974]

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Trefoil Factor 3 antibody [EPR3974] (AB108599)

  • 4
  • 1
Primary Antibodies

AB207170

Anti-UMOD antibody [EPR20071]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UMOD antibody [EPR20071] (AB207170)

  • 5
  • 3
Primary Antibodies

AB7817

Anti-alpha smooth muscle Actin antibody [1A4]

KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha smooth muscle Actin antibody [1A4] (AB7817)

  • 5
  • 105
Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

  • 5
  • 16
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purity
IgG fraction
보관 버퍼
pH: 6.6 Constituents: 0.7% Sodium phosphate, 0.58% Sodium chloride, 0.03% EDTA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Renin also known as angiotensinogenase is a proteolytic enzyme with a molecular weight of approximately 40 kDa. It is mainly expressed in the juxtaglomerular cells of the kidneys. Renin plays an important role in the renin-angiotensin system where it initiates the conversion of angiotensinogen to angiotensin I. This process is the first step in a cascade leading to a series of effects in blood pressure regulation and fluid balance.
Biological function summary

The renin enzyme is responsible for blood pressure control and electrolyte homeostasis. It acts as a significant regulator within the renin-angiotensin aldosterone system (RAAS). By catalyzing the formation of angiotensin I from angiotensinogen renin sets off a sequence of reactions that influence vascular tone and sodium reabsorption. The activity of renin significantly interacts with various cardiovascular functions alongside complex regulatory feedback from other hormones such as aldosterone.

Pathways

Renin is a pivotal part of RAAS and interlinks with multiple cardiovascular pathways. The RAAS pathway involves angiotensinogen renin angiotensin I converting enzyme (ACE) and angiotensin II. Angiotensin II then acts on its receptor to mediate vasoconstriction and aldosterone secretion. The direct relationship between renin and ACE places this enzyme in the center of blood pressure management and has implications on kidney function and homeostasis.

High renin activity has connections with hypertension and cardiovascular diseases. Elevated renin levels contribute to increased angiotensin II production causing vasoconstriction and blood pressure elevation. Disorders like renal hypertension see direct involvement of the renin-angiotensin system. Therapeutic approaches often target RAAS with angiotensin-converting enzyme inhibitors (ACE inhibitors) and angiotensin receptor blockers aiming to mitigate the renin-related impact on these diseases.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
See full target information REN

대체 명칭 보기

Renin, Angiotensinogenase, REN
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제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Biomedicines 10: PubMed35625681

2022

Expression of Pannexin 1 in the Human Kidney during Embryonal, Early Fetal and Postnatal Development and Its Prognostic Significance in Diabetic Nephropathy.

Applications

Unspecified application

Species

Unspecified reactive species

Ivo Jeličić,Katarina Vukojević,Anita Racetin,Davor Čarić,Merica Glavina Durdov,Mirna Saraga-Babić,Natalija Filipović

International journal of molecular sciences 22: PubMed33525532

2021

Alteration of Cx37, Cx40, Cx43, Cx45, Panx1, and Renin Expression Patterns in Postnatal Kidneys of Dab1-/- () Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Mirela Lozić,Natalija Filipović,Marija Jurić,Ivona Kosović,Benjamin Benzon,Ivana Šolić,Nela Kelam,Anita Racetin,Koichiro Watanabe,Yu Katsuyama,Masaki Ogata,Mirna Saraga-Babić,Katarina Vukojević

International journal of molecular sciences 21: PubMed33172216

2020

Connexin Signaling in the Juxtaglomerular Apparatus (JGA) of Developing, Postnatal Healthy and Nephrotic Human Kidneys.

Applications

Unspecified application

Species

Unspecified reactive species

Ivona Kosovic,Natalija Filipovic,Benjamin Benzon,Ivana Bocina,Merica Glavina Durdov,Katarina Vukojevic,Marijan Saraga,Mirna Saraga-Babic

Cell reports 31:107744 PubMed32521269

2020

The Protein Arginine Methyltransferase PRMT8 and Substrate G3BP1 Control Rac1-PAK1 Signaling and Actin Cytoskeleton for Dendritic Spine Maturation.

Applications

Unspecified application

Species

Unspecified reactive species

Louisa Hoi-Ying Lo,Rui Dong,Quanwei Lyu,Kwok-On Lai
제품이 사용된 논문 모두 보기
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Product promise

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