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AB259627

Anti-Renin antibody [EPR22174-8] - BSA and Azide free (Capture)

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Rabbit Recombinant Monoclonal Renin antibody. Carrier free. Suitable for sELISA and reacts with Human samples.
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Sandwich ELISA - Anti-Renin antibody [EPR22174-8] - BSA and Azide free (Capture) (AB259627)
  • sELISA

Supplier Data

Sandwich ELISA - Anti-Renin antibody [EPR22174-8] - BSA and Azide free (Capture) (AB259627)

Representative standard curve from corresponding SimpleStep ELISA® Kit (ab246545).

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR22174-8

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

sELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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보완 제품

Assay Kits

AB138875

Renin Assay Kit (Fluorometric)

Functional Studies - Renin Assay Kit (Fluorometric) (AB138875)

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Sample Prep & Detection Kits

AB269839

158Gd Metal Conjugation Kit - Lightning-Link®

Schematic Diagram - 158Gd Metal Conjugation Kit - Lightning-Link® (AB269839)

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Sample Prep & Detection Kits

AB204911

Antibody Concentration Kit (Gold/Magnetic labelling)

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Primary Antibodies

AB244693

Anti-Neuropilin 1 antibody [EPR20699-137] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-Neuropilin 1 antibody [EPR20699-137] - BSA and Azide free (Capture) (AB244693)

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Proteins & Peptides

AB316630

Recombinant Human Renin Protein Standard (His tag)

Sandwich ELISA - Recombinant Human Renin Protein Standard (His tag) (AB316630)

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Primary Antibodies

AB276020

Anti-FGL1 antibody [EPR24018-140] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-FGL1 antibody [EPR24018-140] - BSA and Azide free (Capture) (AB276020)

  • 0
  • 0
Primary Antibodies

AB242601

Anti-PCSK9 antibody [EPR17827-111] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-PCSK9 antibody [EPR17827-111] - BSA and Azide free (Capture) (AB242601)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }
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제품 세부 정보

ab259627 is a BSA and Azide Free antibody supplied in an unconjugated format and it is suitable for sandwich ELISAs to quantify Human Renin. The recommended pair for sandwich ELISA is:
Capture: ab259627, Human Renin Capture Antibody (unconjugated)
Detector: ab259628, Human Renin Detector Antibody (unconjugated)
The reference range value is 31.25 - 2000 pg/ml.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Sandwich ELISA
The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.

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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Renin also known as angiotensinogenase is a proteolytic enzyme with a molecular weight of approximately 40 kDa. It is mainly expressed in the juxtaglomerular cells of the kidneys. Renin plays an important role in the renin-angiotensin system where it initiates the conversion of angiotensinogen to angiotensin I. This process is the first step in a cascade leading to a series of effects in blood pressure regulation and fluid balance.
Biological function summary

The renin enzyme is responsible for blood pressure control and electrolyte homeostasis. It acts as a significant regulator within the renin-angiotensin aldosterone system (RAAS). By catalyzing the formation of angiotensin I from angiotensinogen renin sets off a sequence of reactions that influence vascular tone and sodium reabsorption. The activity of renin significantly interacts with various cardiovascular functions alongside complex regulatory feedback from other hormones such as aldosterone.

Pathways

Renin is a pivotal part of RAAS and interlinks with multiple cardiovascular pathways. The RAAS pathway involves angiotensinogen renin angiotensin I converting enzyme (ACE) and angiotensin II. Angiotensin II then acts on its receptor to mediate vasoconstriction and aldosterone secretion. The direct relationship between renin and ACE places this enzyme in the center of blood pressure management and has implications on kidney function and homeostasis.

High renin activity has connections with hypertension and cardiovascular diseases. Elevated renin levels contribute to increased angiotensin II production causing vasoconstriction and blood pressure elevation. Disorders like renal hypertension see direct involvement of the renin-angiotensin system. Therapeutic approaches often target RAAS with angiotensin-converting enzyme inhibitors (ACE inhibitors) and angiotensin receptor blockers aiming to mitigate the renin-related impact on these diseases.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
See full target information REN

대체 명칭 보기

Renin, Angiotensinogenase, REN
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Product promise

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