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AB317212

Anti-Respiratory Syncytial virus NS1 antibody [HL2383]

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Rabbit Recombinant Monoclonal NS1 antibody. Suitable for WB and reacts with Transfected cell lysate, Respiratory syncytial virus samples. Immunogen corresponding to Recombinant Fragment Protein within Human respiratory syncytial virus A (strain A2) 1C.

대체 명칭 보기

NS1, Non-structural protein 1, Non-structural protein 1C

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

HL2383

Isotype

IgG

Carrier free

No

Reacts with

Respiratory syncytial virus

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human respiratory syncytial virus A (strain A2) 1C.

P0DOE9

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보완 제품

Primary Antibodies

AB216327

Anti-Occludin antibody [EPR20992]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Occludin antibody [EPR20992] (AB216327)

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  • 7
Primary Antibodies

AB307799

Anti-ZO-1 antibody [HL1185]

Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-ZO-1 antibody [HL1185] (AB307799)

  • 1
  • 1
Primary Antibodies

AB211737

Anti-Claudin 1 antibody [EPRR18871]

20ul selling size|RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-Claudin 1 antibody [EPRR18871] (AB211737)

  • 5
  • 7
Primary Antibodies

AB131259

Anti-Claudin 5 antibody [EPR7583]

RabMAb|Recombinant|20ul selling size

Western blot - Anti-Claudin 5 antibody [EPR7583] (AB131259)

  • 4
  • 7
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Respiratory syncytial virus": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Transfected cell lysate": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
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제품 세부 정보

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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특성 및 보관 정보

제형
Liquid
보관 버퍼
pH: 7.4 Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Respiratory Syncytial Virus (RSV) is a negative-sense single-stranded RNA virus known to cause respiratory infections. It belongs to the Paramyxoviridae family and is sometimes referred to by its alternate names like Human Orthopneumovirus. RSV is approximately 15 kb in size. It is predominantly expressed in the respiratory tract where it attacks epithelial cells leading to infection. The virus's ability to form a syncytium a large multinucleate cell is one of its mechanical strategies to aid in the spread across the host cells.
Biological function summary

The virus propagates efficiently within the host tissue leading to serious respiratory illness in infants and young children. RSV is not part of a specific complex but it engages host cellular machinery to promote its replication and prevent immune detection. The fusion (F) protein of RSV plays a critical role in mediating membrane fusion facilitating viral entry into the host cells. The involvement of viral proteins in modulating host immune responses is significant for the virus's life cycle.

Pathways

Respiratory infections caused by RSV connect to the host's immune signaling pathways including the toll-like receptor (TLR) pathways and the interferon response pathway. The interaction of RSV proteins with these pathways leads to an increased inflammatory response. Proteins such as the RSV G protein interface with the chemokine receptor pathway which helps in modulation of the immune system to allow viral persistence. These interactions demonstrate the virus's strategies to evade immune surveillance and promote infection.

Respiratory syncytial virus is a major cause of bronchiolitis and pneumonia in infants and young children. The virus's activity in the respiratory tract contributes to severe inflammation and cell damage which can lead to hospitalization. Other proteins like RSV M protein are involved in virus assembly and budding and they passively influence disease progression by impacting viral load and the host's immune response. Understanding these interactions is important for developing therapeutic strategies including anti-RSV monoclonal antibodies like palivizumab (2F7) which target prominent viral components to prevent severe disease outcomes.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Plays a major role in antagonizing the type I IFN-mediated antiviral response by degrading or inhibiting multiple cellular factors required for either IFN induction or response pathways (PubMed : 15047850). Acts cooperatively with NS2 to repress activation and nuclear translocation of host IFN-regulatory factor IRF3 (PubMed : 15827150). Also disrupts the association of IRF3 with CREBBP (PubMed : 21632562). Interacts with host mitochondrial-associated membrane (MAM) MAVS and prevents the interaction with RIGI (Probable) (PubMed : 22383950). Interacts with TRIM25 to suppress TRIM25-mediated RIGI ubiquitination and thereby RIGI-MAVS interaction (PubMed : 30558248). Together with NS2, participates in the proteasomal degradation of host STAT2, IRF3, IRF7, TBK1 and RIGI through a NS-degradasome involving CUL2 and Elongin-C (PubMed : 17251292, PubMed : 23877405). The degradasome requires an intact mitochondrial MAVS (PubMed : 23877405). Decreases the levels of host TRAF3 and IKBKE/IKK-epsilon (PubMed : 19625398). As functions other than disruptions of the type I IFN-mediated antiviral signaling pathways, induces host SOCS1 and SOCS3 expression (PubMed : 24480984, PubMed : 26557722). Suppresses premature apoptosis by an NF-kappa-B-dependent, interferon-independent mechanism and thus facilitates virus growth (PubMed : 17151097). Additionally, NS1 may serve some inhibitory role in viral transcription and RNA replication (PubMed : 9445048). Suppresses proliferation and activation of host CD103+ CD8+ cytotoxic T-lymphocytes and Th17 helper T-lymphocytes (PubMed : 21533073).
See full target information 1C
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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