AB317104

Anti-Respiratory Syncytial virus type B G protein antibody [HL1733]

Recombinant
각 태그의 뜻

Be the first to review this product! 리뷰 제출

(0 출판물)

Rabbit Recombinant Monoclonal SHMT1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Transfected cell lysate - Respiratory syncytial virus, Transfected cell line - Respiratory syncytial virus samples. Immunogen corresponding to Recombinant Fragment Protein within Human respiratory syncytial virus B (strain B1) G.

대체 명칭 보기

Major surface glycoprotein G, Attachment glycoprotein G, Membrane-bound glycoprotein, mG

2 이미지

Immunocytochemistry/ Immunofluorescence - Anti-Respiratory Syncytial virus type B G protein antibody [HL1733] (AB317104)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Respiratory Syncytial virus type B G protein antibody [HL1733] (AB317104)

ab317104 detects Respiratory Syncytial virus type B Glycoprotein protein by immunofluorescent analysis.
Sample : Mock and transfected 293T cells were fixed in 4% paraformaldehyde at RT for 15 min.
Green : Respiratory Syncytial virus type B Glycoprotein stained by ab317104 diluted at 1 : 500.
Blue : Fluoroshield with DAPI.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Respiratory Syncytial virus type B G protein antibody [HL1733] (AB317104)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Respiratory Syncytial virus type B G protein antibody [HL1733] (AB317104)

ab317104 detects Respiratory Syncytial virus type B G protein protein by immunohistochemical analysis.
Sample : Paraffin-embedded mock and RSV Type B Major surface glycoprotein G transfected 293T.
Green : Respiratory Syncytial virus type B G protein stained by ab317104 diluted at 1 : 1000.
Blue : Fluoroshield with DAPI.
Antigen Retrieval : Citrate buffer pH 6.0 15 min.

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

HL1733

Isotype

IgG

Carrier free

Reacts with

Respiratory syncytial virus

Applications

WB, ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human respiratory syncytial virus B (strain B1) G.

O36633

style

left-column

style

left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Respiratory syncytial virus": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Transfected cell line - Respiratory syncytial virus": { "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500", "ICCIF-species-notes": "" }, "Transfected cell lysate - Respiratory syncytial virus": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

style

left-column

제품 세부 정보

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

style

left-column

특성 및 보관 정보

제형

Liquid

보관 버퍼

pH: 7.4 Constituents: PBS

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

style

left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The Respiratory Syncytial Virus (RSV) type B G protein also known as the glycoprotein B is a critical component of the RSV envelope. The mass of this protein is approximately 90 kDa. This protein plays a mechanical role by facilitating the attachment of the virus to the host cell surface which is an essential step for viral entry and infection. The G protein expresses on the surface of the RSV particles and helps the virus navigate the host environment thereby enhancing its ability to infect respiratory epithelial cells.

Biological function summary

The RSV type B G protein functions in immune evasion by modulating the host's immune response. It is not part of a larger multiprotein complex but interacts with components of the host immune system to subvert normal immune activities. For example it can interfere with host cell signaling pathways that would typically lead to a robust immune response allowing the virus to persist and propagate within the host tissues.

Pathways

RSV type B G protein actively participates in the infection process by engaging key cellular pathways like the integrin signaling pathway. The G protein interacts with proteins on the host cell surface such as heparan sulfate proteoglycans and CX3C chemokine receptor 1 (CX3CR1) aiding viral attachment and entry. These interactions facilitate subsequent downstream signaling that promotes viral penetration and replication within the host cells.

RSV type B G protein associates closely with conditions like bronchiolitis and pneumonia especially in infants and young children. Its role in immune modulation directly links to how these diseases manifest and progress. Additionally other viral proteins like the F protein contribute to similar pathologies through synergistic actions with the G protein worsening respiratory conditions and increasing the severity of respiratory tract infections.

style

left-column

style

left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

타겟 정보

Isoform Membrane-bound glycoprotein G. Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities.. Isoform Secreted glycoprotein G. Helps the virus escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fc-gamma receptors.

See full target information G

style

left-column

style

left-column

style

right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Respiratory Syncytial virus type B G protein antibody [HL1733]

Immunocytochemistry/ Immunofluorescence - Anti-Respiratory Syncytial virus type B G protein antibody [HL1733] (AB317104)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Respiratory Syncytial virus type B G protein antibody [HL1733] (AB317104)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Proteins & Peptides

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

Product promise