Rabbit Polyclonal Reticulocalbin 3 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RCN3 aa 150-300.
대체 명칭 보기
UNQ239/PRO272, RCN3, Reticulocalbin-3, EF-hand calcium-binding protein RLP49
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Reticulocalbin 3 antibody (AB204178)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human skin tissue labelling Reticulocalbin 3 with ab204178 at 1/2500 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Reticulocalbin 3 antibody (AB204178)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human testis tissue labelling Reticulocalbin 3 with ab204178 at 1/2500 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Reticulocalbin 3 antibody (AB204178)
Immunohistochemical analysis of paraffin-embedded Human cerebral cortex tissue labeling Reticulocalbin 3 with ab204178 at 1/2500 dilution.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Reticulocalbin 3 antibody (AB204178)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human upper gastrointestinal tract tissue labelling Reticulocalbin 3 with ab204178 at 1/2500 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
- ICC/IF
Supplier Data
Immunocytochemistry/ Immunofluorescence - Anti-Reticulocalbin 3 antibody (AB204178)
Immunofluorescent analysis of PFA-fixed,Triton X-100 permeabilized U-2 OS cells labeling Reticulocalbin 3 with ab204178 at 4 μg/ml (green).
- WB
Supplier Data
Western blot - Anti-Reticulocalbin 3 antibody (AB204178)
All lanes:
Western blot - Anti-Reticulocalbin 3 antibody (ab204178) at 0.4 µg/mL
All lanes:
AN3-CA (human endometrium adenocarcinoma cell line) cell lysate
Predicted band size: 37 kDa
false
- WB
CiteAb
Western blot - Anti-Reticulocalbin 3 antibody (AB204178)
Reticulocalbin 3 western blot using anti-Reticulocalbin 3 antibody ab204178. Publication image and figure legend from Cai, R., Wang, P., et al., 2020, J Transl Med, PubMed 32216815.
ab204178 was used in this publication in western blot. This may not be the same as the application(s) guaranteed by Abcam. For a full list of applications guaranteed by Abcam for ab204178 please see the product overview.
Identification and verification of DEPs in ESCC tissues. a Paired ESCC and adjacent normal esophageal tissues from three patients were analyzed by TMT. Twofold change was defined as the threshold for a significant change in expression. We detected 39 proteins up-regulated in cancer tissues compared with that in adjacent normal tissues (paired-samples t-test, p < 0.001). b Gene ontology enrichment analysis of identified DEPs which were classified into cellular component, molecular function, and biological process. c, d Validation of DEPs in ESCA. The expression of FN1, LTBP1, PLOD2, THBS1 and RCN3 were confirmed by GEPIA and western blot analysis. N non-tumorous tissues, T tumorous tissues. (one-way ANOVA and paired-samples t-test, *p < 0.05)
false
Reactivity 정보
특성 및 보관 정보
제형
Purification 테크닉
보관 버퍼
배송 시 보관 조건
적절한 단기 보관 기간
적절한 단기 보관 조건
적절한 장기 보관 조건
분주 정보
보관 정보
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Reticulocalbin 3 plays a role in calcium-dependent signaling processes that affect protein folding and secretion. It is part of a complex involved in glycoprotein maturation and quality control within the endoplasmic reticulum. Reticulocalbin 3 helps ensure proper protein folding which is essential for cellular function. By influencing endoplasmic reticulum stress responses Reticulocalbin 3 contributes to overall cellular health and functionality.
Pathways
The role of Reticulocalbin 3 can be seen in the endoplasmic reticulum-associated degradation (ERAD) pathway and the unfolded protein response (UPR). These pathways help manage protein misfolding and cellular stress levels. Within these pathways Reticulocalbin 3 interacts with proteins like calreticulin and calnexin which are also involved in calcium binding and protein folding mechanisms. Its function supports the regulation and maintenance of protein quality control aiding in the survival of stressed cells.
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제품이 사용된 논문 (6)
Recent publications for all applications. Explore the 전체 목록 and refine your search
Cell death & disease 15:878 PubMed39632825
2024
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Cancers 15: PubMed37046668
2023
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Cancer science 113:3593-3607 PubMed35839283
2022
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Scientific reports 11:10868 PubMed34035379
2021
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EMBO molecular medicine 13:e13074 PubMed33998164
2021
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Journal of translational medicine 18:139 PubMed32216815
2020
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