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AB243536

Anti-REXO1 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal REXO1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human REXO1 aa 200-350.

대체 명칭 보기

ELOABP1, KIAA1138, TCEB3BP1, REXO1, RNA exonuclease 1 homolog, Elongin-A-binding protein 1, Transcription elongation factor B polypeptide 3-binding protein 1, EloA-BP1

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-REXO1 antibody (AB243536)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-REXO1 antibody (AB243536)

Formalin-fixed, paraffin-embedded human rectum tissue stained for REXO1 with ab243536 at a 1/200 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human REXO1 aa 200-350. The exact immunogen used to generate this antibody is proprietary information.

Q8N1G1

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보완 제품

Proteins & Peptides

AB177672

Recombinant Human REXO1 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human REXO1 protein (His tag N-Terminus) (AB177672)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

REXO1 also known as RNA exonuclease 1 homolog is a protein primarily involved in RNA processing. It functions mechanistically as an exonuclease which means it helps cut and process RNA molecules by removing nucleotides from the ends of RNA. This protein has an approximate molecular mass of 126 kDa. Researchers have identified REXO1 expression in various tissues but it is especially present in the testis and ovary indicating roles in reproductive tissue functions.
Biological function summary

REXO1 plays a significant role in maintaining RNA stability and regulating RNA quantity in cells. This protein does not operate alone; it is part of the exosome complex which is indispensable for RNA processing and degradation. Together with other proteins in the complex REXO1 contributes to the maturation of small RNAs and the degradation of defective mRNA molecules. By doing so the protein ensures the proper functioning of cellular RNA dynamics.

Pathways

REXO1 is involved in RNA degradation pathways and the processing of ribosomal RNA (rRNA). Within these pathways it collaborates closely with proteins such as DIS3 and EXOSC10 which are also components of the exosome. This cooperation facilitates the turnover and processing of RNA transcripts which is essential for gene expression regulation. REXO1's involvement in these pathways highlights its integral role in managing RNA homeostasis in cells.

REXO1 has connections to certain reproductive system disorders and cancers. Mutations or dysregulation of this protein can impact fertility potentially leading to conditions like infertility. Its relationship with other proteins such as components of the exosome complex indicates a broader impact on cellular function and genome stability. Furthermore REXO1 is often observed in cancerous cells where it may contribute to the altered RNA metabolism that characterizes many cancer types.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Seems to have no detectable effect on transcription elongation in vitro.
See full target information REXO1
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cancer cell international 21:20 PubMed33407514

2021

Circ-CCDC66 upregulates REXO1 expression to aggravate cervical cancer progression via restraining miR-452-5p.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Zhang,Xing Li,Jun Zhang,Lin Mao

Theranostics 10:8633-8647 PubMed32754268

2020

Identification of a Tumor Microenvironment-relevant Gene set-based Prognostic Signature and Related Therapy Targets in Gastric Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Wang-Yu Cai,Zi-Nan Dong,Xiao-Teng Fu,Ling-Yun Lin,Lin Wang,Guo-Dong Ye,Qi-Cong Luo,Yu-Chao Chen
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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