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AB237511

Anti-RIPX antibody

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Rabbit Polyclonal RIPX antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RUFY3 aa 200-400.

대체 명칭 보기

KIAA0871, RUFY3, Protein RUFY3, RUN and FYVE domain-containing protein 3, Rap2-interacting protein x, Single axon-regulated protein, RIPx, Singar

1 이미지
Immunocytochemistry/ Immunofluorescence - Anti-RIPX antibody (AB237511)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-RIPX antibody (AB237511)

4% formaldehyde-fixed, 0.2% Triton X-100 permeabilized HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for RIPX (green) using ab237511 at 1/133 dilution in ICC/IF, followed by Alexa Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L). Counter-stained with DAPI.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human RUFY3 aa 200-400. The exact immunogen used to generate this antibody is proprietary information.

Q7L099

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보완 제품

Primary Antibodies

AB171080

Anti-C3 / C3a antibody [EPR2987(2)(ABC)(B)]

RabMAb|Recombinant|20ul selling size

Immunoprecipitation - Anti-C3 / C3a antibody [EPR2987(2)(ABC)(B)] (AB171080)

  • 0
  • 0
Primary Antibodies

AB66768

Anti-C5b-9 + C5b-8 antibody [aE11]

Immunohistochemistry (Frozen sections) - Anti-C5b-9 + C5b-8 antibody [aE11] (AB66768)

  • 5
  • 1
Primary Antibodies

AB278017

Anti-C4B-d / C4B-b antibody [EPR23364-147] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-C4B-d / C4B-b antibody [EPR23364-147] - BSA and Azide free (Capture) (AB278017)

  • 0
  • 0
Primary Antibodies

AB126250

Anti-C3a R antibody

Western blot - Anti-C3a R antibody (AB126250)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity greater than 95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

RIPX also known as Receptor Interacting Protein X is a signaling protein with a mass of approximately 74 kDa. This protein acts as an important intermediary within various cellular mechanisms. It is expressed in numerous tissues including the spleen liver and the immune system's vital organs. RIPX possesses a death domain which plays a role in the regulation of cellular responses.
Biological function summary

RIPX has significant roles in the immune response and apoptotic processes. RIPX associates with other proteins to form complex structures that modulate cell death and survival ensuring balanced cellular environments. Through its interactions RIPX influences cytokine production and inflammation which are critical aspects of immune system regulation.

Pathways

The signaling mechanisms involving RIPX have been linked closely with the NF-κB and TNF receptor signaling pathways. RIPX acts as an important node working alongside other proteins like RIP1 and TRAF2 to propagate signals that preclude inflammation and apoptosis. Its regulatory function ensures proper communication within cells affecting the balance between cell death and survival in response to external stimuli.

RIPX has connections to inflammatory diseases such as rheumatoid arthritis and Crohn's disease. Dysregulation of RIPX activity can lead to aberrant inflammation linking it to these pathologies. RIPX interactions with proteins like TNF receptor-associated factors can exacerbate inflammatory responses highlighting a potential target for therapeutic intervention in managing chronic inflammation conditions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

ARL8 effector that promotes the coupling of endolysosomes to dynein-dynactin for retrograde transport along microtubules. Acts by binding both GTP-bound ARL8 and dynein-dynactin. In nonneuronal cells, promotes concentration of endolysosomes in the juxtanuclear area. In hippocampal neurons, drives retrograde transport of endolysosomes from the axon to the soma (PubMed : 35314674). Plays a role in the generation of neuronal polarity formation and axon growth (By similarity). Implicated in the formation of a single axon by developing neurons (By similarity). May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery (PubMed : 25766321). Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones (By similarity).
See full target information RUFY3
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecular and cellular biochemistry 479:929-940 PubMed37256445

2023

miR-206 alleviates LPS-induced inflammatory injury in cardiomyocytes via directly targeting USP33 to inhibit the JAK2/STAT3 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Dong,Jin Chen,Yadong Wang,Junfei Weng,Xingxiang Du,Xu Fang,Wenyu Liu,Tao Long,Jiaxiang You,Wensheng Wang,Xiaoping Peng
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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