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AB171799

Anti-RND3 antibody

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(4 제품이 사용된 논문 )

Mouse Polyclonal RND3 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human RND3.

대체 명칭 보기

ARHE, RHO8, RHOE, RND3, Rho-related GTP-binding protein RhoE, Protein MemB, Rho family GTPase 3, Rho-related GTP-binding protein Rho8, Rnd3

주요 정보

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human RND3.

P61587

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보완 제품

Primary Antibodies

AB181602

Anti-GAPDH antibody [EPR16891] - Loading Control

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GAPDH antibody [EPR16891] - Loading Control (AB181602)

  • 5
  • 23
Primary Antibodies

AB179471

Anti-Integrin beta 1 antibody [EPR16895]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin beta 1 antibody [EPR16895] (AB179471)

  • 5
  • 5
Primary Antibodies

AB187027

Anti-RhoA antibody [EPR18134]

20ul selling size|RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-RhoA antibody [EPR18134] (AB187027)

  • 4
  • 1
Primary Antibodies

AB124979

Anti-Cofilin antibody [EPR6375] - Loading Control

20ul selling size|RabMAb|Recombinant|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-Cofilin antibody [EPR6375] - Loading Control (AB124979)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
pH: 7.4 Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

RND3 also known as RhoE is a small GTPase with a molecular mass of approximately 25 kDa. It belongs to the Rho family of GTPases. RND3 lacks intrinsic GTPase activity which makes it constantly bound to GTP. This protein gets expressed in several tissues including the brain heart and skeletal muscles. By interfering with the actin cytoskeleton RND3 regulates cell shape and movement.
Biological function summary

The functions of RND3 involve the regulation of the cytoskeleton contributing to processes such as cell adhesion and migration. RND3 operates independently not forming part of a larger protein complex yet it plays a pivotal role in modulating the activity of other signaling molecules. Its influence on the cytoskeleton makes it an important player in maintaining cellular architecture and dynamics which is fundamental for tissue integrity and repair.

Pathways

RND3 is intricately involved in the MAPK and PI3K/AKT signaling pathways. These pathways are essential for cell growth migration and survival. RND3 interacts with proteins such as ROCK1 and ROCK2 in these pathways affecting downstream activities positively or negatively. The regulation of these signaling cascades by RND3 shows its importance in cellular responses to environmental cues.

RND3 is linked to cancer and cardiovascular diseases. Alterations in RND3 expression or function can contribute to the uncontrolled cell proliferation seen in various cancers. In cancer its interactions with signaling proteins like AKT lead to enhanced survival signaling. In the context of cardiovascular diseases RND3 influences vascular smooth muscle cell behavior impacting atherosclerosis progression. Through these connections RND3 emerges as a significant target for therapeutic research.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.
See full target information RND3
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제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell death & disease 15:931 PubMed39719443

2024

Mechanistic insights into SIRT7 and EZH2 regulation of cisplatin resistance in bladder cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yudong Cao,Shuo Wang,Jinchao Ma,Mengping Long,Xiuli Ma,Xiao Yang,Yongpeng Ji,Xingxing Tang,Jia Liu,Chen Lin,Yong Yang,Peng Du

Oncogene 40:6329-6342 PubMed34433909

2021

Comprehensive molecular profiling of UV-induced metastatic melanoma in Nme1/Nme2-deficient mice reveals novel markers of survival in human patients.

Applications

Unspecified application

Species

Unspecified reactive species

M Kathryn Leonard,Gemma S Puts,Nidhi Pamidimukkala,Gautam Adhikary,Yili Xu,Eric Kwok,Yuxin Jin,Devin Snyder,Nicolette Matsangos,Marián Novak,Anup Mahurkar,Amol C Shetty,Radomir M Slominski,Edward C De Fabo,Frances P Noonan,Chi-Ping Day,Mohammed Rigi,Andrzej T Slominski,Michelle G Webb,David W Craig,Glenn Merlino,Richard L Eckert,John D Carpten,Zarko Manojlovic,David M Kaetzel

Diabetes 69:689-698 PubMed31949005

2020

Retinopathy in a Diet-Induced Type 2 Diabetic Rat Model and Role of Epigenetic Modifications.

Applications

Unspecified application

Species

Unspecified reactive species

Renu A Kowluru

RSC advances 8:34973-34983 PubMed35547072

2018

Retracted Article: MiR-182-5p and miR-96-5p increased hepatocellular carcinoma cell mobility, proliferation and cisplatin resistance partially by targeting RND3.

Applications

Unspecified application

Species

Unspecified reactive species

Shiming Yang,Zhi Chen,Daguang Fan,Rui Zhang,Yuhong Zhang,Shusheng Wu
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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