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AB241988

Anti-RPL18 antibody

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(4 제품이 사용된 논문 )

Rabbit Polyclonal RPL18 antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human RPL18 aa 1-50.

대체 명칭 보기

Large ribosomal subunit protein eL18, 60S ribosomal protein L18, RPL18

1 이미지
Western blot - Anti-RPL18 antibody (AB241988)
  • WB

Supplier Data

Western blot - Anti-RPL18 antibody (AB241988)

Prepared using NETN lysis buffer.

All lanes:

Western blot - Anti-RPL18 antibody (ab241988) at 0.1 µg/mL

Lane 1:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 50 µg

Lane 2:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) at 50 µg

Lane 3:

Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate at 50 µg

Lane 4:

TCMK-1 (Mouse kidney epithelial cell line) whole cell lysate at 50 µg

Lane 5:

NIH/3T3 (mouse embryo fibroblast cell line) whole cell lysate at 50 µg

Predicted band size: 22 kDa

true

Exposure time: 3s

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human RPL18 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q07020

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대체품

Primary Antibodies

AB254898

Anti-RPL18 antibody

Immunocytochemistry/ Immunofluorescence - Anti-RPL18 antibody (AB254898)

  • 0
  • 0

보완 제품

Primary Antibodies

AB18181

Anti-HA tag antibody [HA.C5]

Lab Essentials

Western blot - Anti-HA tag antibody [HA.C5] (AB18181)

  • 4
  • 19
Primary Antibodies

AB155781

Anti-RPL17 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RPL17 antibody (AB155781)

  • 0
  • 0
Primary Antibodies

AB196652

Anti-RPS24 antibody [EPR16017(B)]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RPS24 antibody [EPR16017(B)] (AB196652)

  • 0
  • 0
Primary Antibodies

AB254671

Anti-RPS25 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RPS25 antibody (AB254671)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
Antibody was affinity purified using an epitope specific to RPL18 immobilized on solid support.
보관 버퍼
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: Tris citrate/phosphate
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

RPL18 also known as Ribosomal Protein L18 is a component of the 60S large ribosomal subunit. It possesses a molecular weight of approximately 22 kDa. RPL18 is highly expressed in various tissues including the liver brain and pancreas. The protein plays an important role in protein synthesis by aiding in the assembly and function of ribosomes essential cellular machinery for translating mRNA into polypeptides.
Biological function summary

RPL18 functions as part of the ribosomal complex facilitating mRNA translation into proteins. This protein is integral to the structure of the ribosome which serves as the platform for accurate peptide bond formation between amino acids. RPL18 like other ribosomal proteins contributes to the stability and efficiency of the ribosome's function during the translation process. Its presence ensures the proper alignment and interaction of ribosomal RNA and other ribosomal proteins.

Pathways

RPL18 is involved in key processes like the protein synthesis pathway and the ribosomal biogenesis pathway. In these pathways RPL18 interacts closely with other ribosomal proteins such as RPL5 and RPL11 which together form the core of the ribosomal assembly machinery. It also plays a role in the regulation of p53 through its interaction with these and other ribosomal proteins that influence cellular stress responses and cell cycle arrest.

Alterations in RPL18 levels or function can be linked to cancer and Diamond-Blackfan anemia. In cancer biology changes in ribosomal proteins including RPL18 may lead to disruptions in the normal patterns of protein synthesis contributing to tumorigenesis. In Diamond-Blackfan anemia a disorder characterized by bone marrow failure mutations in ribosomal proteins like RPL18 can impair ribosome function and affect hematopoiesis. RPL18's association with these conditions often involves interactions with key proteins such as p53 highlighting its broader impact on disease mechanisms.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Component of the large ribosomal subunit (PubMed : 12962325, PubMed : 23636399, PubMed : 25901680, PubMed : 25957688, PubMed : 32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed : 12962325, PubMed : 23636399, PubMed : 25901680, PubMed : 25957688, PubMed : 32669547).
See full target information RPL18
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제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

The Journal of clinical investigation 134: PubMed38875287

2024

Liver cancer initiation requires translational activation by an oncofetal regulon involving LIN28 proteins.

Applications

Unspecified application

Species

Unspecified reactive species

Meng-Hsiung Hsieh,Yonglong Wei,Lin Li,Liem H Nguyen,Yu-Hsuan Lin,Jung M Yong,Xuxu Sun,Xun Wang,Xin Luo,Sarah K Knutson,Christina Bracken,George Q Daley,John T Powers,Hao Zhu

Evidence-based complementary and alternative medicine : eCAM 2022:4016935 PubMed36185082

2022

Experimental Evidence of Buyang Huanwu Decoction and Related Modern Preparations (Naoxintong Capsule and Yangyin Tongnao Granule) in Treating Cerebral Ischemia: Intestinal Microorganisms and Transcriptomics in Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Junjun Yin,Jiehong Yang,Buchang Zhao,Chao Zhao,Wei Fu,Yu He,Miaolin Zeng,Yuting Yang,Xiaoyu Wei,Zhishan Ding,Jingxian Bai,Haitong Wan,Huifen Zhou

Communications biology 4:823 PubMed34193971

2021

Age-dependent shift in the de novo proteome accompanies pathogenesis in an Alzheimer's disease mouse model.

Applications

Unspecified application

Species

Unspecified reactive species

Megan K Elder,Hediye Erdjument-Bromage,Mauricio M Oliveira,Maggie Mamcarz,Thomas A Neubert,Eric Klann

Biomedical reports 14:36 PubMed33732455

2021

Aberrant proteins expressed in skin fibroblasts of Parkinson's disease patients carrying heterozygous variants of glucocerebrosidase and parkin genes.

Applications

Unspecified application

Species

Unspecified reactive species

Phannee Sawangareetrakul,Lukana Ngiwsara,Voraratt Champattanachai,Daranee Chokchaichamnankit,Kittirat Saharat,James R Ketudat Cairns,Chantragan Srisomsap,Kawinthra Khwanraj,Permphan Dharmasaroja,Teeratorn Pulkes,Jisnuson Svasti
제품이 사용된 논문 모두 보기
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Product promise

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