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AB238332

Anti-RSK3 antibody

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Rabbit Polyclonal RSK3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RPS6KA2 aa 200-400.

대체 명칭 보기

MAPKAPK1C, RSK3, RPS6KA2, Ribosomal protein S6 kinase alpha-2, S6K-alpha-2, 90 kDa ribosomal protein S6 kinase 2, MAP kinase-activated protein kinase 1c, Ribosomal S6 kinase 3, pp90RSK3, p90-RSK 2, p90RSK2, MAPK-activated protein kinase 1c, MAPKAP kinase 1c, MAPKAPK-1c, RSK-3

2 이미지
Immunocytochemistry/ Immunofluorescence - Anti-RSK3 antibody (AB238332)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-RSK3 antibody (AB238332)

HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for RSK3 (Green) using ab238332 at a 1/66 dilution in ICC/IF.

The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal goat serum. The cells were then incubated with the primary antibody overnight at 4°C. Secondary used is an Alexa-Fluor®488-conjugated Goat Anti-Rabbit IgG (H+L). Counterstained with DAPI.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RSK3 antibody (AB238332)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RSK3 antibody (AB238332)

Paraffin-embedded human lung cancer tissue stained for RSK3 with ab238332 at a 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human RPS6KA2 aa 200-400. The exact immunogen used to generate this antibody is proprietary information.

Q15349

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대체품

Primary Antibodies

AB227230

Anti-RSK3 antibody

Western blot - Anti-RSK3 antibody (AB227230)

  • 0
  • 0

보완 제품

Primary Antibodies

AB32114

Anti-RSK1 p90 antibody [E4]

20ul selling size|RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-RSK1 p90 antibody [E4] (AB32114)

  • 5
  • 4
Primary Antibodies

AB32413

Anti-RSK1 p90 (phospho T359) antibody [E238]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RSK1 p90 (phospho T359) antibody [E238] (AB32413)

  • 5
  • 8
Primary Antibodies

AB108319

Anti-BDNF antibody [EPR1292]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Western blot - Anti-BDNF antibody [EPR1292] (AB108319)

  • 4
  • 10
Proteins & Peptides

AB60882

Recombinant human RSK3 protein (GST tag N-Terminus)

Functional Studies - Recombinant human RSK3 protein (AB60882)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

RSK3 also known as ribosomal S6 kinase 2 or RPS6KA2 is a serine/threonine-protein kinase with a molecular mass of about 90 kDa. RSK3 belongs to the p90-RSK family of kinases comprising four isoforms (RSK1 RSK2 RSK3 and RSK4) which are downstream effectors of the MAPK/ERK pathway. It is ubiquitously expressed with significant expression in the brain heart and skeletal muscle.
Biological function summary

RSK3 acts in cell growth survival and differentiation. The kinase participates in forming signaling complexes that transmit signals from the cell membrane to the nucleus. RSK3 modulates the activity of several substrates including transcription factors and other kinases by phosphorylating specific serine/threonine residues. RSK3 interacts with complexes involved in cell adhesion and migration facilitating cellular responses to external stimuli.

Pathways

RSK3 plays a role in the MAPK/ERK pathway which is important for mediating responses to growth factors. This pathway interlinks with other signaling cascades including those involving the PI3K/AKT pathway. RSK3 phosphorylates substrates such as ribosomal protein S6 and the transcription factor CREB which influence protein synthesis and gene expression. Its related proteins such as RSK1 and RSK2 also contribute to fine-tuning these cellular pathways.

RSK3 is associated with cancer and cardiac hypertrophy. Dysregulation of RSK3 signaling can lead to enhanced cell proliferation and reduced apoptosis contributing to tumorigenesis. It interacts with other proteins including AKT in pathways that promote cancer cell survival. In cardiac hypertrophy RSK3 plays a role in maladaptive processes leading to heart enlargement linked to interaction with proteins like ERK. Understanding RSK3's role in these conditions can guide therapeutic strategies targeting its signaling pathways.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.
See full target information RPS6KA2
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Oncology letters 29:15 PubMed39492940

2024

UL16‑binding protein 1 is a significant prognostic and diagnostic marker for breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaowei Zhang,Shuhong Dai,Liang Li,Pengyun Wang,Mingxin Dong
제품이 사용된 논문 모두 보기
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Product promise

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