AB172402

Anti-SACM1L/Sac1 antibody

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Rabbit Polyclonal SACM1L/Sac1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SACM1L.

대체 명칭 보기

KIAA0851, SAC1, SACM1L, Phosphatidylinositol-3-phosphatase SAC1, Phosphatidylinositol-4-phosphate phosphatase, Suppressor of actin mutations 1-like protein

1 이미지

Immunocytochemistry/ Immunofluorescence - Anti-SACM1L/Sac1 antibody (AB172402)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SACM1L/Sac1 antibody (AB172402)

Immunocytochemistry of HeLa cells staining SACM1L/Sac1 using ab172402 at 30 μg/ml.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Full Length Protein corresponding to Human SACM1L.

Q9NTJ5

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "30 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

보관 버퍼

pH: 7.4 Constituents: PBS

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SACM1L also known as Sac1 is an integral enzyme in the cell performing its role as a phosphoinositide phosphatase. It has a mass of approximately 59 kDa. SACM1L localizes in the cytoplasm and the membrane systems of the endoplasmic reticulum and Golgi apparatus where it performs its enzymatic activities. Its expression is observed in many tissues with particular abundance in the brain and testis. The protein's ability to dephosphorylate phosphoinositides highlights its mechanical role in cellular lipid metabolism.

Biological function summary

This enzyme regulates intracellular lipid signaling and trafficking by modulating the levels of phosphoinositides. SACM1L is part of a protein complex involving other regulatory proteins that maintain the balance of lipid phosphates. Through its enzymatic activity SACM1L influences membrane dynamics and vesicular transport within cells. Taken together these activities show its importance in maintaining cellular homeostasis and function.

Pathways

SACM1L plays a role in phosphatidylinositol signaling and the vesicle-mediated transport pathway. Its action in these pathways involves interaction with proteins such as PIKfyve and Synaptojanin which are present in similar signaling events. SACM1L ensures the proper turnover of phosphatidylinositides which is critical for membrane identity and function in transport processes. These interactions highlight SACM1L's relevance to key signaling cascades within the cell.

SACM1L is implicated in neurodegenerative diseases and congenital disorders of glycosylation. Mutations or dysregulation in SACM1L have been linked to certain types of hereditary spastic paraplegia where it influences neuronal function and integrity. Additionally SACM1L's connection with proteins such as PGP and other phosphatases suggests its involvement in maintaining glycosylation patterns and cellular stress responses. Understanding its connection to these diseases could provide insights into novel therapeutic strategies.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P) (PubMed : 24209621, PubMed : 27044890, PubMed : 29461204, PubMed : 30659099). Can also catalyze the hydrolysis of phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Shows a very robust PtdIns(4)P phosphatase activity when it binds PtdIns(4)P in a 'cis' configuration in the cellular environment, with much less activity seen when it binds PtdIns(4)P in 'trans' configuration (PubMed : 24209621, PubMed : 29461204, PubMed : 30659099). PtdIns(4)P phosphatase activity (when it binds PtdIns(4)P in 'trans' configuration) is enhanced in the presence of PLEKHA3 (PubMed : 30659099).

See full target information SACM1L

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell reports 30:1935-1950.e8 PubMed32049022

2020

Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Patrick J Metz,Keith A Ching,Tao Xie,Paulina Delgado Cuenca,Sherry Niessen,John H Tatlock,Kristen Jensen-Pergakes,Brion W Murray

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SACM1L/Sac1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-SACM1L/Sac1 antibody (AB172402)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (1)

Product promise