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AB244275

Anti-SALL2 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal SALL2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SALL2 aa 1-200.

대체 명칭 보기

KIAA0360, SAL2, ZNF795, SALL2, Sal-like protein 2, Zinc finger protein 795, Zinc finger protein SALL2, Zinc finger protein Spalt-2, Sal-2, hSal2

4 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SALL2 antibody (AB244275)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SALL2 antibody (AB244275)

Formalin-fixed, paraffin-embedded human cerebellum tissue stained for SALL2 with ab244275 at a 1/200 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SALL2 antibody (AB244275)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SALL2 antibody (AB244275)

Formalin-fixed, paraffin-embedded human liver tissue shows absence of immunoreactivity for SALL2 when incubated with ab244275 at a 1/200 dilution (negative control).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SALL2 antibody (AB244275)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SALL2 antibody (AB244275)

Formalin-fixed, paraffin-embedded human tonsil tissue shows absence of immunoreactivity for SALL2 when incubated with ab244275 at a 1/200 dilution (negative control).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SALL2 antibody (AB244275)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SALL2 antibody (AB244275)

Formalin-fixed, paraffin-embedded human cerebral cortex tissue stained for SALL2 with ab244275 at a 1/200 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SALL2 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

Q9Y467

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보완 제품

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Primary Antibodies

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Primary Antibodies

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Primary Antibodies

AB227883

Anti-Dnmt3b antibody - N-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dnmt3b antibody - N-terminal (AB227883)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SALL2 also known as Sal-like protein 2 is a transcription factor with a molecular mass of approximately 120 kDa. It functions as a DNA-binding protein that regulates gene expression. SALL2 contains conserved zinc finger motifs that facilitate its binding to target DNA sequences influencing transcriptional activation or repression of specific genes. The protein is mainly expressed in the central nervous system retina and hematopoietic tissues where it exerts its regulatory functions.
Biological function summary

This protein plays essential roles in neural development and cell cycle regulation. SALL2 belongs to the SALL family of proteins which are key in developmental processes. It interacts with other members of this family to form transcriptional regulatory complexes modulating the expression of genes involved in differentiation growth and apoptosis. Through these complexes SALL2 can affect various cellular responses including proliferation and survival.

Pathways

Several cellular processes depend on this protein's activity. SALL2 significantly influences the p53 pathway which is important for DNA damage response and cell cycle control. Interaction with p53-related proteins results in modulation of cell cycle arrest and apoptosis. Additionally the retinoblastoma (RB) pathway important for controlling cell proliferation is impacted by SALL2 as it interacts with RB protein to regulate cell cycle progression in response to external growth signals.

SALL2 has been implicated in certain cancers particularly in the context of tumor suppression. Alterations in SALL2 expression or function can lead to uncontrolled cell proliferative disorders making it a potential biomarker for cancer. Furthermore studies suggest a link between SALL2 and retinal disorders due to its expression in retinal cells and interactions with retina-specific proteins. Understanding the role of SALL2 in these diseases offers insights into therapeutic targets and strategies for future interventions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Probable transcription factor that plays a role in eye development before, during, and after optic fissure closure.
See full target information SALL2
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell reports 43:114309 PubMed38848215

2024

Lineage specification in glioblastoma is regulated by METTL7B.

Applications

Unspecified application

Species

Unspecified reactive species

Myrianni Constantinou,James Nicholson,Xinyu Zhang,Eleni Maniati,Sara Lucchini,Gabriel Rosser,Claire Vinel,Jun Wang,Yau Mun Lim,Sebastian Brandner,Sven Nelander,Sara Badodi,Silvia Marino

STAR protocols 1:100150 PubMed33377044

2020

Protocol for Large-Scale Production of Kidney Organoids from Human Pluripotent Stem Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Veronika Sander,Aneta Przepiorski,Amanda E Crunk,Neil A Hukriede,Teresa M Holm,Alan J Davidson
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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