AB204510

Anti-SARI antibody

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(5 제품이 사용된 논문 )

Rabbit Polyclonal SARI antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human BATF2 aa 1-50.

대체 명칭 보기

Basic leucine zipper transcriptional factor ATF-like 2, B-ATF-2, Suppressor of AP-1 regulated by IFN, SARI, BATF2

5 이미지

Immunocytochemistry/ Immunofluorescence - Anti-SARI antibody (AB204510)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SARI antibody (AB204510)

SK-MEL-30 cells stained for SARI (green) using ab204510 at 2 μg/ml in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SARI antibody (AB204510)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SARI antibody (AB204510)

Paraffin embedded human testis tissue stained for SARI using ab204510 at 1/500 dilution in immunohistochemical analysis.

Heat mediated antigen retrieval was performed with citrate buffer pH 6 before the IHC staining protocol.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SARI antibody (AB204510)

Paraffin embedded human colon tissue stained for SARI using ab204510 at 1/500 dilution in immunohistochemical analysis.

Heat mediated antigen retrieval was performed with citrate buffer pH 6 before the IHC staining protocol.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SARI antibody (AB204510)

Paraffin embedded human kidney tissue stained for SARI using ab204510 at 1/500 dilution in immunohistochemical analysis.

Heat mediated antigen retrieval was performed with citrate buffer pH 6 before the IHC staining protocol.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SARI antibody (AB204510)

Paraffin embedded human Fallopian tube tissue stained for SARI using ab204510 at 1/500 dilution in immunohistochemical analysis.

Heat mediated antigen retrieval was performed with citrate buffer pH 6 before the IHC staining protocol.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human BATF2 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q8N1L9

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SARI also known as suppressor of AP-1 regulates apoptosis and inflammation in cells. It is a protein with a molecular mass of around 64 kDa. SARI is mainly expressed in immune cells including macrophages and dendritic cells and also found in epithelial tissues. The protein acts mainly in the cytoplasm where it interacts with other molecules to carry out its functions.

Biological function summary

SARI modulates transcription processes involved in immune responses. It forms part of a regulatory complex that includes other proteins like TRAF3 and TBK1 to influence NF-κB signaling pathways. Through this complex SARI can suppress certain transcription factors thereby regulating gene expression linked to inflammation. This regulation helps maintain balanced immune responses ensuring cells do not overreact to stimuli.

Pathways

SARI interacts with the tumor necrosis factor (TNF) and toll-like receptor (TLR) signaling pathways. In these pathways SARI influences how cells respond to cytokines and infectious agents. It achieves this by interacting with key pathway proteins such as TRAF3 and RIPK1. These interactions allow SARI to mediate the downstream effects ultimately affecting cell survival and immune reactions.

SARI has roles in inflammatory diseases and cancer. In inflammatory diseases such as rheumatoid arthritis SARI influences the activity of inflammation-related proteins like NF-κB which can exacerbate or alleviate symptoms. In cancer SARI has been implicated in regulating tumor growth and metastasis interacting with other cancer-related proteins such as STAT3. These connections make SARI a potential therapeutic target in managing these conditions.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively suppresses CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CCN1 and inhibits CCN1-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CCN1 promoter.

See full target information BATF2

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제품이 사용된 논문 (5)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell cycle (Georgetown, Tex.) 22:100-116 PubMed35949109

2022

m6A modification-mediated BATF2 suppresses metastasis and angiogenesis of tongue squamous cell carcinoma through inhibiting VEGFA.

Applications

Unspecified application

Species

Unspecified reactive species

Haojie Wen,Jinyong Tang,Yi Cui,Minhua Hou,Juan Zhou

Pathology oncology research : POR 28:1610273 PubMed35369571

2022

RING-Finger Protein 6 promotes Drug Resistance in Retinoblastoma JAK2/STAT3 Signaling Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yong Chai,Shoufeng Jiao,Xin Peng,Qiang Gan,Leifeng Chen,Xiaolu Hu,Liang Hao,Shouhua Zhang,Qiang Tao

Frontiers in molecular biosciences 8:724373 PubMed34778372

2021

Diagnostic and Prognostic Potential of Circulating and Tissue BATF2 in Nasopharyngeal Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Zhaolei Cui,Yingying Lin,Dan Hu,Jing Wu,Wei Peng,Yan Chen

BMC cancer 21:1062 PubMed34565331

2021

Expression and clinical implications of basic leucine zipper ATF-like transcription factor 2 in breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yingying Lin,Xusheng Zhou,Wei Peng,Jing Wu,Xiufeng Wu,Yan Chen,Zhaolei Cui

The Journal of dermatology 47:e372-e373 PubMed32696470

2020

BATF2 expression as a novel marker for invasive phenotype in malignant melanoma.

Applications

Unspecified application

Species

Unspecified reactive species

Hidemi Tagawa,Hisashi Kanemaru,Toshihiro Kimura,Haruka Kuriyama,Soichiro Sawamura,Ikko Kajihara,Azusa Miyashita,Jun Aoi,Satoshi Fukushima,Hironobu Ihn

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SARI antibody

Immunocytochemistry/ Immunofluorescence - Anti-SARI antibody (AB204510)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SARI antibody (AB204510)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SARI antibody (AB204510)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SARI antibody (AB204510)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SARI antibody (AB204510)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (5)

Product promise