AB244219

Anti-SCGN/Secretagogin antibody [CL0271]

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Mouse Monoclonal SCGN/Secretagogin antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SCGN aa 100 to C-terminus.

대체 명칭 보기

SECRET, SCGN, Secretagogin

4 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCGN/Secretagogin antibody [CL0271] (AB244219)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCGN/Secretagogin antibody [CL0271] (AB244219)

Paraffin-embedded human pancreas tissue stained for SCGN/Secretagogin using ab244219 at 1/2500 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCGN/Secretagogin antibody [CL0271] (AB244219)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCGN/Secretagogin antibody [CL0271] (AB244219)

Paraffin-embedded human cerebellum tissue stained for SCGN/Secretagogin using ab244219 at 1/2500 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCGN/Secretagogin antibody [CL0271] (AB244219)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCGN/Secretagogin antibody [CL0271] (AB244219)

Paraffin-embedded human duodenum tissue stained for SCGN/Secretagogin using ab244219 at 1/2500 dilution in immunohistochemical analysis.

Western blot - Anti-SCGN/Secretagogin antibody [CL0271] (AB244219)

WB

Supplier Data

Western blot - Anti-SCGN/Secretagogin antibody [CL0271] (AB244219)

All lanes:

Western blot - Anti-SCGN/Secretagogin antibody [CL0271] (ab244219) at 1 µg/mL

All lanes:

Human brain tissue lysate

Predicted band size: 32 kDa

false

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

CL0271

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

Immunogen

Recombinant Fragment Protein within Human SCGN aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

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대체품

Primary Antibodies

AB111871

Anti-SCGN/Secretagogin antibody

Immunohistochemistry (Frozen sections) - Anti-SCGN/Secretagogin antibody (AB111871)

0
0

Primary Antibodies

AB137017

Anti-SCGN/Secretagogin antibody [EPR7477]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCGN/Secretagogin antibody [EPR7477] (AB137017)

5
1

Primary Antibodies

AB138493

Anti-SCGN/Secretagogin antibody [EPR7476]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCGN/Secretagogin antibody [EPR7476] (AB138493)

0
0

Primary Antibodies

AB211362

Anti-SCGN/Secretagogin antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCGN/Secretagogin antibody (AB211362)

0
0

보완 제품

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-S100 beta antibody [EP1576Y] - Astrocyte Marker (AB52642)

4
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Primary Antibodies

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5
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Primary Antibodies

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Flow Cytometry (Intracellular) - Anti-Chromogranin A antibody [RM1025] (AB283265)

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Primary Antibodies

AB192757

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Western blot - Anti-PSD95 antibody [K28/43] - Synaptic Marker (AB192757)

0
0

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/2500 - 1/5000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SCGN also known as Secretagogin is a calcium-binding protein with a molecular weight of approximately 33 kDa. It belongs to the family of EF-hand superfamily proteins which is known for its role in various cellular processes. Secretagogin predominantly expresses in neuroendocrine tissues such as the pancreas and central nervous system where it binds calcium and possibly modulates its signaling. It has drawn interest due to its distinctive expression pattern and potential role in regulated secretion.

Biological function summary

The role of Secretagogin extends beyond simple calcium binding. It participates in managing cytoskeleton dynamics through its ability to bind calcium impacting processes like vesicle trafficking. Although not part of a standard protein complex Secretagogin interacts with other cytoskeletal proteins and may influence the release of hormones. Its role in neurotransmission and insulin secretion showcases its significance in both the nervous and endocrine systems.

Pathways

Secretagogin interacts within signaling networks such as the calcium-signaling and insulin-secretion pathways. It has established relationships with other proteins like actin influencing cellular architecture and trafficking. Through these pathways Secretagogin appears instrumental in processes involving rapid response times such as neurotransmitter release or hormone secretion often acting in conjunction with or supporting other calcium-binding proteins.

Secretagogin has connections to diabetes and certain neuroendocrine tumors. Its involvement in insulin secretion makes it relevant in the context of diabetes where it might interact with malfunctioning insulin-related proteins. Additionally in neuroendocrine tumors altered Secretagogin expression could be linked with oncogenic processes as it shares pathways with proteins involved in cell-cycle regulation. Understanding these associations can aid in identifying potential therapeutic targets or biomarkers for these diseases.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

See full target information SCGN

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nature neuroscience 28:1598-1609 PubMed40659844

2025

An expanded subventricular zone supports postnatal cortical interneuron migration in gyrencephalic brains.

Applications

Unspecified application

Species

Unspecified reactive species

JaeYeon Kim,Aunoy Poddar,Kadellyn Sandoval,Julia Chu,Emma Horton,Di Cui,Keira Nakamura,I-Ling Lu,Michael Mui,Theresa Bartels,Christian M Wood,Susana I Ramos,David H Rowitch,Nadejda M Tsankova,Hosung Kim,Chet C Sherwood,Boris W Kramer,Angela C Roberts,Pablo J Ross,Duan Xu,Nicola J Robertson,Elizabeth A Maga,Peng Ji,Mercedes F Paredes

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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