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AB219816

Anti-SCN4B antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal SCN4B antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human Sodium channel subunit beta-4 aa 50-150.

대체 명칭 보기

Sodium channel regulatory subunit beta-4, SCN4B

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCN4B antibody (AB219816)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCN4B antibody (AB219816)

Immunohistochemical analysis of paraffin embedded formalin fixed human colon issue labeling SCN4B using ab219816 at 1/100 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCN4B antibody (AB219816)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCN4B antibody (AB219816)

Immunohistochemical analysis of paraffin embedded formalin fixed human prostate issue labeling SCN4B using ab219816 at 1/100 dilution.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human Sodium channel subunit beta-4 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.

Q8IWT1

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대체품

Primary Antibodies

AB80539

Anti-SCN4B antibody

Immunocytochemistry/ Immunofluorescence - Anti-SCN4B antibody (AB80539)

  • 5
  • 2

보완 제품

Primary Antibodies

AB313343

Anti-Influenza A Virus Nucleoprotein antibody [EPR28253-17]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Influenza A Virus Nucleoprotein antibody [EPR28253-17] (AB313343)

  • 5
  • 1
Primary Antibodies

AB214337

Anti-Flavivirus NS1 antibody [D/2/D6/B7]

Immunocytochemistry/ Immunofluorescence - Anti-Flavivirus NS1 antibody [D/2/D6/B7] (AB214337)

  • 0
  • 0
Primary Antibodies

AB65166

Anti-Nav1.6/SCN8A antibody

Western blot - Anti-Nav1.6/SCN8A antibody (AB65166)

  • 5
  • 4
Primary Antibodies

AB2912

Anti-Caveolin-3 antibody - Caveolae Marker

Lab Essentials

Immunocytochemistry - Anti-Caveolin-3 antibody - Caveolae Marker (AB2912)

  • 4
  • 11
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SCN4B also known as Sodium Channel Beta-4 Subunit is a vital component in the modulation of voltage-gated sodium channels. Its molecular mass is approximately 22 kDa. SCN4B is primarily expressed in muscle tissue and the central nervous system. It functions as an auxiliary subunit to modulate the activity and kinetics of the main alpha subunit in sodium channels therefore influencing neuronal excitability and muscle contraction.
Biological function summary

SCN4B regulates the proper functioning of sodium channels which are essential for the initiation and propagation of action potentials in neurons and muscle fibers. SCN4B does not typically form a complex on its own but works as part of the sodium channel macromolecular complex. The interaction with alpha subunits modulates the gating behavior and the cellular localization of the channel impacting how electrical signals are handled in excitable cells.

Pathways

The sodium channels influenced by SCN4B are integral to the action potential pathway and the muscle contraction pathway. SCN4B's interaction with alpha subunits like SCN4A influences signal transmission efficiency and precision. The proteins SCN5A and SCN1A are also part of these sodium channel pathways playing similar roles in different tissues such as cardiac and nervous systems.

SCN4B has connections to conditions such as periodic paralysis and epilepsy. Mutations or dysregulation of SCN4B can alter neuronal excitability contributing to pathophysiological conditions. The protein links to SCN4A in conditions involving muscle function and SCN1A in neuronal-related disorders demonstrating its role in maintaining normal electrical activity and stability across tissues.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels (PubMed : 24297919). Modulates the activity of SCN1A/Nav1.1 (PubMed : 33712547). Modulates the activity of SCN2A/Nav1.2 (PubMed : 24297919).
See full target information Sodium channel subunit beta-4
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

iScience 27:110668 PubMed39246442

2024

Multiplex imaging of localized prostate tumors reveals altered spatial organization of AR-positive cells in the microenvironment.

Applications

Unspecified application

Species

Unspecified reactive species

Çiğdem Ak,Zeynep Sayar,Guillaume Thibault,Erik A Burlingame,M J Kuykendall,Jennifer Eng,Alex Chitsazan,Koei Chin,Andrew C Adey,Christopher Boniface,Paul T Spellman,George V Thomas,Ryan P Kopp,Emek Demir,Young Hwan Chang,Vasilis Stavrinides,Sebnem Ece Eksi

Journal of translational medicine 19:174 PubMed33902636

2021

Identification of key methylation differentially expressed genes in posterior fossa ependymoma based on epigenomic and transcriptome analysis.

Applications

Unspecified application

Species

Unspecified reactive species

Guanyi Wang,Yibin Jia,Yuqin Ye,Enming Kang,Huijun Chen,Jiayou Wang,Xiaosheng He
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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