AB235110

Anti-Sec14l3/TAP2 antibody

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(3 제품이 사용된 논문 )

Rabbit Polyclonal Sec14l3/TAP2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SEC14L3 aa 200-400.

대체 명칭 보기

TAP2, SEC14L3, SEC14-like protein 3, Tocopherol-associated protein 2

2 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sec14l3/TAP2 antibody (AB235110)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sec14l3/TAP2 antibody (AB235110)

Paraffin-embedded human testis tissue stained for Sec14l3/TAP2 using ab235110 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sec14l3/TAP2 antibody (AB235110)

Paraffin-embedded human lung cancer tissue stained for Sec14l3/TAP2 using ab235110 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human SEC14L3 aa 200-400. The exact immunogen used to generate this antibody is proprietary information.

Q9UDX4

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein G

Purification 관련 사항

Purity >95%

보관 버퍼

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Sec14l3 also known as TAP2 or Sec14-like protein 3 is a member of the sec14 lipid transfer protein family. It has a molecular mass of approximately 45 kDa. Sec14l3 is expressed in various tissues including the brain suggesting its importance in neural functions. Mechanically Sec14l3 plays a role in lipid binding and transfer assisting in the regulation of phospholipid metabolism important for cellular homeostasis.

Biological function summary

This protein interacts with phosphatidylinositol and phosphatidylcholine contributing to lipid signaling and transport. Sec14l3 is part of a larger complex involved in lipid metabolism influencing various cellular functions by controlling lipid levels within the cell. It modulates membrane trafficking impacting neuron transmission and signaling pathways that direct cellular responses and development.

Pathways

Significant functions of Sec14l3 occur within phosphoinositide signaling and the vesicular transport pathway. It relates to essential proteins in these pathways such as PI3K and small GTPases which govern cell growth survival and intracellular trafficking processes. These interactions affect how cells respond to external signals balancing growth and response to their environment.

Sec14l3 has associations with neurological disorders and cancer. Its interaction with PI3K hints at its role in pathways altered in glioblastomas while its influence on lipid signaling connects it to diseases like Alzheimer's where lipid dysregulation is a factor. Further studies highlight potential links with proteins like tau and amyloid precursor protein in these contexts suggesting pathways for disease progression and potential therapeutic targets.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.

See full target information SEC14L3

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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Communications biology 8:658 PubMed40274982

2025

Copper-mediated SEC14L3 promotes cuproptosis to inhibit hepatocellular carcinoma growth via ERK/YY1/FDX1 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Chutian Wu,Linjing Long,Min Wang,Lianli Shen,Jianjun Hu,Huijun Tang,Shufen Feng,Xiongxiu Liu,Ying Shi,Shaohui Tang,Yanfang Chen

American journal of cancer research 12:5286-5299 PubMed36504904

2022

Chronic stress promotes tumor immune evasion via the suppression of MHC-I expression and the upregulation of PD-L1.

Applications

Unspecified application

Species

Unspecified reactive species

Yuzhu Chen,Yazhi Qian,Wei Huang,Yi Zhang,Mo Wu,Yinlong Cheng,Nan Yang,Yanyong Liu

JCI insight 5: PubMed32161190

2020

Impaired lymphocyte function and differentiation in CTPS1-deficient patients result from a hypomorphic homozygous mutation.

Applications

Unspecified application

Species

Unspecified reactive species

Emmanuel Martin,Norbert Minet,Anne-Claire Boschat,Sylvia Sanquer,Steicy Sobrino,Christelle Lenoir,Jean Pierre de Villartay,Maria Leite-de-Moraes,Capucine Picard,Claire Soudais,Tim Bourne,Sophie Hambleton,Stephen M Hughes,Robert F Wynn,Tracy A Briggs,Smita Patel,Monica G Lawrence,Alain Fischer,Peter D Arkwright,Sylvain Latour

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Sec14l3/TAP2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sec14l3/TAP2 antibody (AB235110)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sec14l3/TAP2 antibody (AB235110)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (3)

Product promise