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AB262869

Anti-SEC24A antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal SEC24A antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Protein transport protein Sec24A aa 100-250.

대체 명칭 보기

Protein transport protein Sec24A, SEC24-related protein A, SEC24A

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SEC24A antibody (AB262869)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SEC24A antibody (AB262869)

Paraffin-embedded human stomach tissue stained for SEC24A using ab262869 at 1/50 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human Protein transport protein Sec24A aa 100-250. The exact immunogen used to generate this antibody is proprietary information.

O95486

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보완 제품

Primary Antibodies

AB122633

Anti-Sec24C antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sec24C antibody (AB122633)

  • 0
  • 0
Primary Antibodies

AB155278

Anti-SAR1B + SAR1A antibody [EPR10105(B)]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SAR1B + SAR1A antibody [EPR10105(B)] (AB155278)

  • 5
  • 3
Primary Antibodies

AB75852

Anti-Cathepsin D antibody [EPR3057Y]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Western blot - Anti-Cathepsin D antibody [EPR3057Y] (AB75852)

  • 5
  • 11
Primary Antibodies

AB171870

Rabbit IgG, polyclonal - Isotype Control (ChIP Grade)

Western blot - Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (AB171870)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SEC24A also known as SEC24-related gene family member A is a protein that participates in the process of vesicle formation. It has a molecular mass of approximately 121 kDa. SEC24A is expressed in various tissues including the liver brain and pancreas. It plays an important role in the secretory pathway by helping select and package cargo proteins into vesicles that bud from the endoplasmic reticulum (ER). This protein works alongside other components of the COPII complex to ensure specific transport of proteins to their correct cellular destinations.
Biological function summary

SEC24A functions as part of the COPII vesicle coat complex in eukaryotic cells. It helps in selecting and recognizing cargo proteins for transport from the ER to the Golgi apparatus. By binding directly to cargo proteins or indirectly through adaptor proteins SEC24A aids in their incorporation into vesicles. The COPII complex which also includes SEC23 SEC13 and SEC31 is important for effective protein trafficking and maintenance of cellular homeostasis.

Pathways

SEC24A participates significantly in the secretory pathway and ER-to-Golgi transport. It interacts with other pathway proteins such as SAR1 and SEC23 which are essential for COPII vesicle budding and fusion. SEC24A's function in these pathways is critical for cellular processes such as hormone release extracellular matrix construction and lipid metabolism. Its activity ensures proper protein distribution directly affecting cell growth and survival.

SEC24A has connections to cardiovascular diseases and metabolic disorders. Mutations or dysregulation of SEC24A may result in disturbed lipid metabolism contributing to conditions like hyperlipidemia. Additionally the protein's involvement in vesicle trafficking links it to cardiac diseases where improper protein transport can lead to cellular stress and dysfunction. SEC24A's interactive role with proteins like SAR1 can lead to disruptions when they are not functioning properly further emphasizing its impact on disease progression.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed : 17499046, PubMed : 18843296, PubMed : 20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24B may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes (PubMed : 17499046, PubMed : 18843296).
See full target information Protein transport protein Sec24A
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nature communications 16:2535 PubMed40087276

2025

ER O-glycosylation in synovial fibroblasts drives cartilage degradation.

Applications

Unspecified application

Species

Unspecified reactive species

Le Son Tran,Joanne Chia,Xavier Le Guezennec,Keit Min Tham,Anh Tuan Nguyen,Virginie Sandrin,Way Cherng Chen,Tan Tong Leng,Sreedharan Sechachalam,Khai Pang Leong,Frederic A Bard

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11:e2405127 PubMed39361436

2024

SEC31a-ATG9a Interaction Mediates the Recruitment of COPII Vesicles for Autophagosome Formation.

Applications

Unspecified application

Species

Unspecified reactive species

Jiaming Nie,Shaoyang Ma,Linyue Wu,Ye Li,Jiao Cao,Meng Li,Peter Mei,Paul R Cooper,Ang Li,Dandan Pei
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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