JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB241336

Anti-Sec24C antibody

4

(2 리뷰들)

|

(2 제품이 사용된 논문 )

Rabbit Polyclonal Sec24C antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SEC24C aa 1-50.

대체 명칭 보기

KIAA0079, SEC24C, Protein transport protein Sec24C, SEC24-related protein C

2 이미지
Immunoprecipitation - Anti-Sec24C antibody (AB241336)
  • IP

Supplier Data

Immunoprecipitation - Anti-Sec24C antibody (AB241336)

Sec24C was immunoprecipitated from HEK-293T (Human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) prepared using NETN lysis buffer.
ab241336 used for IP at 6 μg per reaction. For WB 0.4 μg/ml.

Lane 1 : ab241336 IP in HEK-293T whole cell lysate.
Lane 2 : Control IgG IP in HEK-293T whole cell lysate.

Chemiluminescence detection : 1 seconds.

All lanes:

Immunoprecipitation - Anti-Sec24C antibody (ab241336)

Predicted band size: 118 kDa

false

Western blot - Anti-Sec24C antibody (AB241336)
  • WB

Supplier Data

Western blot - Anti-Sec24C antibody (AB241336)

Prepared using NETN lysis buffer.

All lanes:

Western blot - Anti-Sec24C antibody (ab241336) at 0.1 µg/mL

Lane 1:

HeLa (Human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 50 µg

Lane 2:

HEK-293T (Human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate at 50 µg

Lane 3:

Jurkat (Human T cell leukemia cell line from peripheral blood) whole cell lysate at 50 µg

Lane 4:

TCMK-1 (Mouse kidney epithelial cell line) whole cell lysate at 50 µg

Lane 5:

NIH/3T3 (Mouse embryo fibroblast cell line) whole cell lysate at 50 µg

Predicted band size: 118 kDa

true

Exposure time: 1s

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, Mouse

Applications

IP, WB

applications

Immunogen

Synthetic Peptide within Human SEC24C aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

P53992

style
left-column

대체품

Primary Antibodies

AB122633

Anti-Sec24C antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sec24C antibody (AB122633)

  • 0
  • 0

보완 제품

Primary Antibodies

AB262869

Anti-SEC24A antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SEC24A antibody (AB262869)

  • 0
  • 0
Primary Antibodies

AB172730

Rabbit IgG, monoclonal [EPR25A] - Isotype Control

RabMAb|Advanced Validation|Recombinant

Flow Cytometry - Rabbit IgG, monoclonal [EPR25A] - Isotype Control (AB172730)

  • 0
  • 0
Primary Antibodies

AB187706

Anti-ATP6V1H antibody

Immunoprecipitation - Anti-ATP6V1H antibody (AB187706)

  • 0
  • 0
Primary Antibodies

AB70722

Anti-SEC16A/SEC16 antibody

Immunoprecipitation - Anti-SEC16A/SEC16 antibody (AB70722)

  • 4
  • 6
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-10 µg/mg of lysate", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: Tris citrate/phosphate
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The protein Sec24C also known as SEC24 family member C functions in vesicular trafficking. It belongs to the COPII coat complex which plays a role in transporting proteins from the endoplasmic reticulum to the Golgi apparatus. Sec24C is part of a family with a molecular mass of approximately 125 kDa and it is ubiquitously expressed in various tissues suggesting an essential role in cellular transport mechanisms.
Biological function summary

Sec24C is involved in the formation of COPII-coated vesicles which are essential for the anterograde transport of proteins. It serves as a cargo adaptor within the COPII complex consisting also of proteins such as Sec23 Sec13 and Sec31. The interaction of Sec24C with these proteins ensures the proper selection and packaging of cargo during vesicle budding therefore maintaining effective intracellular transport.

Pathways

Sec24C plays a role in the secretory pathway and is involved in the ER-to-Golgi transport. It functions in collaboration with other COPII components facilitating the packaging and movement of secretory proteins. Key proteins associated with this pathways include Sar1 and Sec23 which coordinate with Sec24C to regulate vesicle formation and cargo selection efficiently.

Disruptions in Sec24C function have been linked to neurological conditions such as Alzheimer's disease and certain forms of neurodegeneration. Altered Sec24C activity affects vesicle trafficking and protein processing interacting with proteins like APP (Amyloid precursor protein) which may lead to pathology. Understanding the role of Sec24C and its interactions could offer insights into therapeutic strategies for these diseases.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed : 10214955, PubMed : 17499046, PubMed : 18843296, PubMed : 20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed : 17499046, PubMed : 18843296, PubMed : 20427317). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed : 20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed : 18843296).
See full target information SEC24C
style
left-column

제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nature communications 13:6977 PubMed36379959

2022

Interruption of post-Golgi STING trafficking activates tonic interferon signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Xintao Tu,Ting-Ting Chu,Devon Jeltema,Kennady Abbott,Kun Yang,Cong Xing,Jie Han,Nicole Dobbs,Nan Yan

Nature communications 13:646 PubMed35115501

2022

Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Francesco De Logu,Romina Nassini,Alan Hegron,Lorenzo Landini,Dane D Jensen,Rocco Latorre,Julia Ding,Matilde Marini,Daniel Souza Monteiro de Araujo,Paulina Ramírez-Garcia,Michael Whittaker,Jeffri Retamal,Mustafa Titiz,Alessandro Innocenti,Thomas P Davis,Nicholas Veldhuis,Brian L Schmidt,Nigel W Bunnett,Pierangelo Geppetti
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com