AB151023

Anti-SELH antibody

Name: Anti-SELH antibody
Brand: Abcam Limited
SKU: AB151023
Rating: 5 (1 reviews)

(1 리뷰)

(4 제품이 사용된 논문 )

Rabbit Polyclonal SELH antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SELENOH aa 50 to C-terminus.

대체 명칭 보기

C11orf31, SELH, SELENOH, Selenoprotein H, SelH

5 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SELH antibody (AB151023)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SELH antibody (AB151023)

Immunohistochemical analysis of paraffin embedded human small intestine tissue labeling SELH at the nucleus of lymphoid cells with ab151023 antibody at a 1/50 dilution.

Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SELH antibody (AB151023)

Immunohistochemical analysis of paraffin embedded human tonsil tissue labeling SELH at the nucleus of non-germinal center cells with ab151023 antibody at a 1/50 dilution.

Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunocytochemistry/ Immunofluorescence - Anti-SELH antibody (AB151023)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-SELH antibody (AB151023)

Immunofluorescence analysis of MCF7 (human breast adenocarcinoma cell line) whole cells labelling SELH at the nucleus and nucleoli with ab151023 at 2 μg/ml.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SELH antibody (AB151023)

Immunohistochemical analysis of paraffin embedded human prostate tissue labeling SELH at the nucleus of glandular cells with ab151023 antibody at a 1/50 dilution.

Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SELH antibody (AB151023)

Immunohistochemical analysis of paraffin embedded human cerebral cortex tissue labeling SELH at the nucleus neurons with ab151023 antibody at a 1/50 dilution.

Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human SELENOH aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8IZQ5

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100</p>" }, "Chimpanzee": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Chinese hamster": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Horse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rhesus monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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제품 세부 정보

The antibody solution should be gently mixed before use.

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SELH also known as Selenoprotein H is a selenocysteine-containing protein with a molecular mass of approximately 15 kDa. It functions in redox regulation and protection against oxidative stress by facilitating antioxidant defense mechanisms. SELH is mainly expressed in the brain and to a lesser extent in other tissues. It belongs to the selenoprotein family which includes proteins containing the rare amino acid selenocysteine responsible for its unique enzymatic capabilities.

Biological function summary

Selenoprotein H contributes to protecting cells from oxidative damage. It plays a role in regenerating antioxidant molecules and maintaining cellular redox balance. SELH is not known to be part of a larger protein complex but works in concert with other antioxidant molecules to enhance cellular resistance to oxidative stress. It also involves gene regulation particularly through modulating transcription factors that respond to oxidative signals.

Pathways

Selenoprotein H engages significantly in the cellular antioxidant pathways and redox homeostasis. It interacts with enzymes like glutathione peroxidase and thioredoxin reductases which are essential in countering oxidative stress. These interactions help maintain signal transduction pathways which depend on redox-sensitive components affecting cellular metabolism and survival. SELH along with these proteins ensures proper cellular function by modulating oxidative status and impacting pathways related to energy metabolism and apoptosis.

Selenoprotein H relates notably to neurodegenerative diseases and certain cancers. SELH’s role in protecting neurons from oxidative stress connects it to conditions like Alzheimer's disease where oxidative stress contributes to neuronal degradation. Additionally it is involved with the tumor suppressor protein p53 which responds to oxidative stress in cancer development. SELH’s antioxidant activity can influence these pathways impacting disease progression and therapeutic responses.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

May be involved in a redox-related process.

See full target information SELENOH

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제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Biological trace element research : PubMed40555955

2025

Supranutritional Selenomethionine but not Selenite Reduces Malignant Cell Transformation.

Applications

Unspecified application

Species

Unspecified reactive species

Caroline E Meyer,Maria Schwarz,Felix B Meyer,René Thierbach,Anna P Kipp

Redox biology 37:101746 PubMed33059313

2020

Copper interferes with selenoprotein synthesis and activity.

Applications

Unspecified application

Species

Unspecified reactive species

Maria Schwarz,Kristina Lossow,Katja Schirl,Julian Hackler,Kostja Renko,Johannes Florian Kopp,Tanja Schwerdtle,Lutz Schomburg,Anna Patricia Kipp

Nutrients 11: PubMed31491970

2019

Crosstalk of Nrf2 with the Trace Elements Selenium, Iron, Zinc, and Copper.

Applications

Unspecified application

Species

Unspecified reactive species

Maria Schwarz,Kristina Lossow,Johannes F Kopp,Tanja Schwerdtle,Anna P Kipp

Nutrients 7:2687-706 PubMed25867950

2015

Differential acute effects of selenomethionine and sodium selenite on the severity of colitis.

Applications

Unspecified application

Species

Unspecified reactive species

Franziska Hiller,Lisa Oldorff,Karolin Besselt,Anna Patricia Kipp

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SELH antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SELH antibody (AB151023)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SELH antibody (AB151023)

Immunocytochemistry/ Immunofluorescence - Anti-SELH antibody (AB151023)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SELH antibody (AB151023)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SELH antibody (AB151023)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (4)

Product promise