JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB122587

Anti-SELT antibody

Be the first to review this product! 리뷰 제출

|

(1 출판물)

Rabbit Polyclonal SELT antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SELENOT aa 100 to C-terminus.

대체 명칭 보기

SELT, UNQ150/PRO176, SELENOT, Thioredoxin reductase-like selenoprotein T, SelT

4 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SELT antibody (AB122587)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SELT antibody (AB122587)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human duodenum tissue labelling SELT with ab122587 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SELT antibody (AB122587)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SELT antibody (AB122587)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human cerebral cortex tissue labelling SELT with ab122587 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SELT antibody (AB122587)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SELT antibody (AB122587)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human liver tissue labelling SELT with ab122587 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SELT antibody (AB122587)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SELT antibody (AB122587)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human cerebellum tissue labelling SELT with ab122587 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SELENOT aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P62341

style
left-column

보완 제품

Primary Antibodies

AB184787

Anti-Caspase-3 antibody [EPR18297]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Caspase-3 antibody [EPR18297] (AB184787)

  • 3
  • 3
Primary Antibodies

AB126618

Anti-COMT antibody [EPR6490]

20ul selling size|RabMAb|Recombinant|KO Validated

Western blot - Anti-COMT antibody [EPR6490] (AB126618)

  • 0
  • 1
Primary Antibodies

AB137431

Anti-Glutathione Peroxidase 2/GPX2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glutathione Peroxidase 2/GPX2 antibody (AB137431)

  • 0
  • 0
Primary Antibodies

AB121276

Anti-SELK antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SELK antibody (AB121276)

  • 0
  • 0
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
보관 정보
Avoid freeze / thaw cycle|Store undiluted
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SELT also known as selenoprotein T is a selenocysteine-containing protein with a molecular mass of approximately 23 kDa. SELT shows expression in various tissues including the brain and endocrine glands. SELT locates itself in the endoplasmic reticulum membrane and plays a mechanical role as a redox enzyme. This protein is involved in thiol-disulfide exchange reactions which are critical for maintaining cellular homeostasis.
Biological function summary

Thiol-disulfide exchange reactions facilitated by SELT support proper cellular differentiation and protein folding. SELT is not known to form part of a larger protein complex and exerts its function individually within cells. Its role in redox homeostasis influences many cellular processes including growth and apoptosis. SELT activity affects cellular redox balance which is significant for overall cell health and survival.

Pathways

SELT's activity contributes to important biological pathways such as the oxidative stress response pathway and the endoplasmic reticulum-associated degradation (ERAD) pathway. In the oxidative stress response SELT acts alongside proteins like glutathione peroxidases to neutralize reactive oxygen species. Within the ERAD pathway SELT assists in maintaining homeostasis by ensuring misfolded proteins are correctly managed therefore working closely with key proteins like ubiquitin in protein degradation processes.

SELT function impacts oxidative stress-related conditions and neuroendocrine disorders. Oxidative stress imbalance is a known factor in Alzheimer's disease where SELT's functionality can influence disease progression interacting with proteins such as amyloid precursor protein (APP). Additionally SELT has relevance in disorders associated with hormone imbalance or production linking SELT indirectly with proteins like insulin in diabetes.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress and cell death (PubMed : 26866473). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion (By similarity).
See full target information SELENOT
style
left-column

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nature communications 15:3793 PubMed38714822

2024

An interphase actin wave promotes mitochondrial content mixing and organelle homeostasis.

Applications

Unspecified application

Species

Unspecified reactive species

Stephen M Coscia,Andrew S Moore,Cameron P Thompson,Christian F Tirrito,E Michael Ostap,Erika L F Holzbaur
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com