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AB236894

Anti-SERINC1 antibody

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Rabbit Polyclonal SERINC1 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SERINC1 aa 300-400.

대체 명칭 보기

KIAA1253, TDE1L, TDE2, UNQ396/PRO732, SERINC1, Serine incorporator 1, Tumor differentially expressed protein 1-like, Tumor differentially expressed protein 2

1 이미지
Immunocytochemistry/ Immunofluorescence - Anti-SERINC1 antibody (AB236894)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SERINC1 antibody (AB236894)

HepG2 (human liver hepatocellular carcinoma cell line) cells stained for SERINC1 (green) using ab236894 at 1/100 dilution in ICC/IF. Secondary antibody is Alexa Fluor® 488-congugated Goat Anti-Rabbit IgG (H+L).

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human SERINC1 aa 300-400. The exact immunogen used to generate this antibody is proprietary information.

Q9NRX5

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보완 제품

Primary Antibodies

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Anti-DAGLB antibody - C-terminal

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Primary Antibodies

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Anti-Ki67 antibody [SP6]

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Primary Antibodies

AB230894

Anti-JHDM1D antibody

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Primary Antibodies

AB282458

Anti-PD-L1 antibody [RM1012]

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  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SERINC1 also known as Serine Incorporator 1 is a membrane protein involved in the incorporation of serine into lipids. It has a molecular mass of approximately 53 kDa. Scientists have identified SERINC1 as highly expressed in several tissues including the brain testis and liver. The protein localizes largely at the plasma membrane and participates actively in lipid biosynthesis.
Biological function summary

SERINC1 modulates the synthesis of phosphatidylserine and sphingolipids which are critical for cellular functions. It acts as part of a larger complex playing a role in the folding and trafficking of proteins to the membrane. SERINC1's activity influences membrane-related processes which include vesicle trafficking and cell signaling. In particular the protein impacts cellular processes through the regulation of membrane composition.

Pathways

Researchers have placed SERINC1 within the lipid metabolism and serine biosynthesis pathways. SERINC1 regulates the distribution of serine into pathways necessary for lipid and nucleotide synthesis. Other proteins related to these pathways include CDP-diacylglycerol—serine O-phosphate phosphatidyltransferase 1 which is key in the phosphatidylserine biosynthetic process. The interaction between these proteins ensures proper cellular lipid composition and function.

Studies have linked SERINC1 to neurological and metabolic conditions. Dysregulation of SERINC1 is observed in some cases of schizophrenia suggesting its involvement in neurological pathways. Furthermore disturbances in lipid metabolism such as those found in metabolic syndrome may involve altered SERINC1 function. Its relationship with proteins like phosphatidylserine decarboxylase central to the production of phosphatidylethanolamine highlights its relevance in disease contexts where lipid imbalances are pronounced.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Enhances the incorporation of serine into phosphatidylserine and sphingolipids.
See full target information SERINC1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Frontiers in bioengineering and biotechnology 8:456 PubMed32500067

2020

Optimisation of a Novel Bio-Substrate as a Treatment for Atrophic Age-Related Macular Degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Rachel McCormick,Ian Pearce,Stephen Kaye,Atikah Haneef
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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