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AB233265

Anti-Serum Amyloid P/SAP antibody

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(1 출판물)

Rabbit Polyclonal Serum Amyloid P/SAP antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human APCS aa 1 to C-terminus.

대체 명칭 보기

PTX2, APCS, Serum amyloid P-component, SAP, 9.5S alpha-1-glycoprotein

8 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Serum Amyloid P/SAP antibody (AB233265)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Serum Amyloid P/SAP antibody (AB233265)

Formalin-fixed, paraffin-embedded human stomach cancer tissue stained for Serum Amyloid P/SAP using ab233265 at 30 ug/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Serum Amyloid P/SAP antibody (AB233265)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Serum Amyloid P/SAP antibody (AB233265)

Formalin-fixed, paraffin-embedded human glioma tissue stained for Serum Amyloid P/SAP using ab233265 at 30 ug/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Serum Amyloid P/SAP antibody (AB233265)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Serum Amyloid P/SAP antibody (AB233265)

Formalin-fixed, paraffin-embedded human kidney tissue stained for Serum Amyloid P/SAP using ab233265 at 30 ug/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Serum Amyloid P/SAP antibody (AB233265)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Serum Amyloid P/SAP antibody (AB233265)

Formalin-fixed, paraffin-embedded human lung cancer tissue stained for Serum Amyloid P/SAP using ab233265 at 30 ug/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Serum Amyloid P/SAP antibody (AB233265)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Serum Amyloid P/SAP antibody (AB233265)

Formalin-fixed, paraffin-embedded human liver tissue stained for Serum Amyloid P/SAP using ab233265 at 30 ug/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Serum Amyloid P/SAP antibody (AB233265)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Serum Amyloid P/SAP antibody (AB233265)

Formalin-fixed, paraffin-embedded human liver cancer tissue stained for Serum Amyloid P/SAP using ab233265 at 30 ug/ml in immunohistochemical analysis. DAB staining.

Western blot - Anti-Serum Amyloid P/SAP antibody (AB233265)
  • WB

Supplier Data

Western blot - Anti-Serum Amyloid P/SAP antibody (AB233265)

All lanes:

Western blot - Anti-Serum Amyloid P/SAP antibody (ab233265) at 2 µg/mL

Lane 1:

Human serum

Lane 2:

Human urine

Secondary

All lanes:

HRP-Linked Guinea pig anti-rabbit at 1/2000 dilution

Predicted band size: 25 kDa

false

Western blot - Anti-Serum Amyloid P/SAP antibody (AB233265)
  • WB

Supplier Data

Western blot - Anti-Serum Amyloid P/SAP antibody (AB233265)

All lanes:

Western blot - Anti-Serum Amyloid P/SAP antibody (ab233265) at 2 µg/mL

All lanes:

Recombinant human Serum Amyloid P/SAP protein

Predicted band size: 25 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human APCS aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P02743

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대체품

Primary Antibodies

AB27313

Anti-Serum Amyloid P/SAP antibody [14B4]

Western blot - Anti-Serum Amyloid P/SAP antibody [14B4] (AB27313)

  • 5
  • 2
Primary Antibodies

AB45151

Anti-Serum Amyloid P/SAP antibody [EP1018Y]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Serum Amyloid P/SAP antibody [EP1018Y] (AB45151)

  • 5
  • 3
Primary Antibodies

AB232468

Anti-Serum Amyloid P/SAP antibody [EP1018Y] - BSA and Azide free

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Serum Amyloid P/SAP antibody [EP1018Y] - BSA and Azide free (AB232468)

  • 0
  • 0

보완 제품

Assay Kits

AB246537

Human SAP ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human SAP ELISA Kit (AB246537)

  • 0
  • 0
Primary Antibodies

AB201811

Anti-PD1 antibody [NAT105] - BSA and Azide free

BOND RX™ Validated|Recombinant

Immunohistochemistry (Frozen sections) - Anti-PD1 antibody [NAT105] - BSA and Azide free (AB201811)

  • 0
  • 0
Primary Antibodies

AB32520

Anti-STAT6 antibody [YE361]

20ul selling size|Recombinant|Advanced Validation|RabMAb|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STAT6 antibody [YE361] (AB32520)

  • 5
  • 1
Primary Antibodies

AB32072

Anti-c-Myc antibody [Y69] - ChIP Grade

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-c-Myc antibody [Y69] - ChIP Grade (AB32072)

  • 4
  • 56
Primary Antibodies

AB53490

Anti-PAX8 antibody [PAX8R1]

Immunocytochemistry - Anti-PAX8 antibody [PAX8R1] (AB53490)

  • 3
  • 6
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-2 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
보관 버퍼
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Serum Amyloid P component also known as SAP P-SAP or APCS protein is a pentraxin family member. It has a molecular mass of approximately 25 kDa. SAP expresses mainly in the liver and circulates in blood plasma. The protein consists of five identical subunits which form a homopentameric structure. This structure enables SAP to bind to amyloid fibrils a defining mechanical action of this protein.
Biological function summary

SAP plays a role in the immune system by recognizing damaged cells and pathogens. It acts as an opsonin marking these cellular targets for phagocytosis. As part of a complex SAP stabilizes extracellular matrix and amyloid deposits. It binds specifically to amyloid fibrils found in various tissues potentially facilitating their removal by immune cells. The protein's binding actions are important for its role in maintaining tissue and fluid homeostasis.

Pathways

SAP is actively involved in the innate immune response and amyloidogenic pathways. It interacts with the complement system to enhance the clearance of cell debris and amyloid fibrils. The complement system is an important component of innate immunity where SAP can engage with complement proteins like C1q. This interaction suggests that SAP plays roles in modulating both inflammation and tissue repair processes.

SAP has significant connections. SAP is related to systemic amyloidosis where it binds to amyloid deposits affecting multiple organs. Moreover SAP has been implicated in Alzheimer's disease due to its interaction with beta-amyloid protein plaques. In these disorders the involvement of SAP aids researchers in understanding the pathological mechanisms and could open avenues for targeted therapies aimed at modulating SAP functions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.
See full target information APCS
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Drug design, development and therapy 17:1819-1829 PubMed37360572

2023

Luteolin Alleviates Liver Fibrosis in Rat Hepatic Stellate Cell HSC-T6: A Proteomic Analysis.

Applications

Unspecified application

Species

Unspecified reactive species

Batudeligen,Zhiqiang Han,Hongmei Chen, Narisu,Yanhua Xu, Anda,Gegentaoli Han
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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