Anti-SESN2/Sestrin-2 antibody

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Functions as an intracellular leucine sensor that negatively regulates the mTORC1 signaling pathway through the GATOR complex (PubMed : 18692468, PubMed : 25263562, PubMed : 25457612, PubMed : 26449471, PubMed : 26586190, PubMed : 26612684, PubMed : 31586034, PubMed : 35114100, PubMed : 35831510, PubMed : 36528027). In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents mTORC1 signaling (PubMed : 18692468, PubMed : 25263562, PubMed : 25457612, PubMed : 26449471, PubMed : 26586190, PubMed : 26612684, PubMed : 31586034, PubMed : 35114100, PubMed : 35831510, PubMed : 36528027). Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed : 26449471, PubMed : 26586190, PubMed : 35114100, PubMed : 35831510, PubMed : 36528027). This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via mTORC1 (PubMed : 24947615). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed : 23274085). May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed : 18692468). Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (PubMed : 26612684). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed : 15105503). However, this could not be confirmed (PubMed : 19113821).