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AB216603

Anti-SETBP1 antibody [SP312]

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(1 출판물)

Rabbit Recombinant Monoclonal SETBP1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication.

대체 명칭 보기

KIAA0437, SETBP1, SET-binding protein, SEB

10 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603)

Immunohistochemical analysis of formalin-fixed paraffin-embedded human urinary bladder transitional cell carcinoma tissue labeling SETBP1 with ab216603 at 1/100 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603)

Immunohistochemical analysis of formalin-fixed paraffin-embedded human HK lymphoma tissue labeling SETBP1 with ab216603 at 1/100 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603)

Immunohistochemical analysis of formalin-fixed paraffin-embedded human urinary bladder tissue labeling SETBP1 with ab216603 at 1/100 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603)

Immunohistochemical analysis of formalin-fixed paraffin-embedded human pancreas tissue labeling SETBP1 with ab216603 at 1/100 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603)

Immunohistochemical analysis of formalin-fixed paraffin-embedded human pancreatic adenocarcinoma tissue labeling SETBP1 with ab216603 at 1/100 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603)

Immunohistochemical analysis of formalin-fixed paraffin-embedded human colon adenocarcinoma tissue labeling SETBP1 with ab216603 at 1/100 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603)

Immunohistochemical analysis of formalin-fixed paraffin-embedded human liver tissue labeling SETBP1 with ab216603 at 1/100 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603)

Immunohistochemical analysis of formalin-fixed paraffin-embedded human lymph node tissue labeling SETBP1 with ab216603 at 1/100 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603)

Immunohistochemical analysis of formalin-fixed paraffin-embedded human colon tissue labeling SETBP1 with ab216603 at 1/100 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603)

Immunohistochemical analysis of formalin-fixed paraffin-embedded human B cell lymphoma tissue labeling SETBP1 with ab216603 at 1/100 dilution.

관련 conjugated 항체와 다양한 조성의 항체 (1)

  • Carrier free

    Anti-SETBP1 antibody [SP312] - BSA and Azide free

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

SP312

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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보완 제품

Primary Antibodies

AB32363

Anti-c-Kit antibody [YR145]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-c-Kit antibody [YR145] (AB32363)

  • 4
  • 10
Primary Antibodies

AB218810

Anti-CD47 antibody [EPR21794]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD47 antibody [EPR21794] (AB218810)

  • 5
  • 1
Primary Antibodies

AB227682

Anti-PDK1 antibody [SP270] - C-terminal

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PDK1 antibody [SP270] - C-terminal (AB227682)

  • 0
  • 0
Primary Antibodies

AB53494

Anti-Biotin antibody

Immunoprecipitation - Anti-Biotin antibody (AB53494)

  • 5
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "<p>Boil tissue section in EDTA buffer, pH 8.0 for 10 min followed by cooling at room temperature for 20 min. Primary incubation for 10 minutes at room temperature.</p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A/G
Purification 관련 사항
Purified from TCS by protein A/G.
보관 버퍼
pH: 7.6 Preservative: 0.099% Sodium azide Constituents: PBS, 1% BSA
배송 시 보관 조건
Conditional Ambient
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SETBP1 also known as SET Binding Protein 1 is a protein encoded by the SETBP1 gene. It has a mass of approximately 170 kDa. SETBP1 binds to SET a protein involved in regulation of cell cycle and apoptosis. It is mainly expressed in the nucleus of cells particularly in tissues such as brain heart liver and muscle. Its localization in the nucleus indicates its role in gene regulation and chromatin organization.
Biological function summary

SETBP1 impacts transcriptional regulation by interacting with other proteins and modifying chromatin structure. While it is not a part of a classic multi-protein complex it influences the function of complexes involved in DNA repair and replication. This protein has a regulatory effect on pathways influencing cell maturation and proliferation making its role significant in cellular homeostasis.

Pathways

SETBP1 plays important roles in intracellular signaling specifically the PI3K/AKT pathway and the Wnt signaling pathway. In these pathways it modulates cell growth survival and differentiation by interacting with proteins like AKT and beta-catenin. These interactions help balance cell processes like apoptosis and proliferation essential for normal development and function.

SETBP1 alterations are linked to Schinzel-Giedion syndrome and some leukemias. Mutations in SETBP1 can affect DNA repair mechanisms leading to disorders related to impaired genomic stability. In leukemia SETBP1 mutations often associate with overexpression of proteins such as SET which drive disease progression by disrupting normal cell cycle regulation. Understanding SETBP1's roles and interactions can aid in developing therapies targeting these mutations.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

See full target information SETBP1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Biology open 12: PubMed37670689

2023

CRISPR/Cas9-mediated knockout of the ubiquitin variant UbKEKS reveals a role in regulating nucleolar structures and composition.

Applications

Unspecified application

Species

Unspecified reactive species

Julie Frion,Anna Meller,Gwendoline Marbach,Dominique Lévesque,Xavier Roucou,François-Michel Boisvert
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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