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AB73893

Anti-SFRS4/SRSF4 antibody

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(3 제품이 사용된 논문 )

Rabbit Polyclonal SFRS4/SRSF4 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human SRSF4.
1 이미지
Western blot - Anti-SFRS4/SRSF4 antibody (AB73893)
  • WB

Unknown

Western blot - Anti-SFRS4/SRSF4 antibody (AB73893)

All lanes:

Western blot - Anti-SFRS4/SRSF4 antibody (ab73893) at 1/500 dilution

Lane 1:

extracts from LoVo cells at 20 µg

Lane 2:

extracts from LoVo cells at 20 µg with immunizing peptide

Predicted band size: 57 kDa

Observed band size: 20 kDa,48 kDa,57 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human SRSF4. The exact immunogen used to generate this antibody is proprietary information.

Q08170

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대체품

Primary Antibodies

AB235606

Anti-SFRS4/SRSF4 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS4/SRSF4 antibody (AB235606)

  • 0
  • 0
Primary Antibodies

AB217285

Anti-SFRS4/SRSF4 antibody

Western blot - Anti-SFRS4/SRSF4 antibody (AB217285)

  • 0
  • 0

보완 제품

Primary Antibodies

AB254935

Anti-SRSF10 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SRSF10 antibody (AB254935)

  • 0
  • 0
Primary Antibodies

AB140623

Anti-SR protein repeat/SRSF6 antibody [EPR9231]

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SR protein repeat/SRSF6 antibody [EPR9231] (AB140623)

  • 0
  • 0
Primary Antibodies

AB67175

Anti-SRSF5 antibody

KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SRSF5 antibody (AB67175)

  • 5
  • 1
Primary Antibodies

AB83306

Anti-SNRP70/U1-70K antibody

BOND RX™ Validated

Western blot - Anti-SNRP70/U1-70K antibody (AB83306)

  • 4
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SFRS4 also known as SRSF4 or splicing factor SRp75 is a serine/arginine-rich splicing factor that plays a central role in pre-mRNA splicing. It has a molecular mass of approximately 75 kDa. SRSF4 contributes to the accurate assembly of spliceosomes by binding to specific RNA sequences through its RNA recognition motifs. This protein is expressed ubiquitously with higher expression levels observed in tissues like the brain and heart indicating its importance for proper cellular functions in these areas.
Biological function summary

Splicing is an important process in the regulation of gene expression and SRSF4 actively participates in this essential function by guiding the splicing machinery to the appropriate splice sites. SRSF4 is part of the highly conserved SR protein family which functions collectively as a complex to regulate alternative splicing events. Alternative splicing allows for the generation of multiple protein isoforms from a single gene significantly expanding the proteomic diversity.

Pathways

Alternative splicing regulated by SRSF4 integrates into the larger RNA processing and post-transcriptional modification network. SRSF4 is involved in the mRNA splicing pathway and interacts with various other splicing factors such as SRSF1 and U2AF. These interactions allow precise execution of splicing and efficient production of mature messenger RNA preparatory for translation processes downstream.

Mutations or dysregulation of SRSF4 have connections with several conditions including cancer and neurodegenerative diseases. Abnormal splicing patterns regulated by SRSF4 can lead to the production of oncogenic isoforms in various cancers. In neurodegenerative diseases its altered function might disturb neuronal alternative splicing patterns impacting protein diversity vital for neuronal functions. SRSF4 interacts with proteins like SRSF2 and hnRNPs in these pathological contexts influencing the disease progression through defective splicing mechanisms.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10.
See full target information SRSF4

대체 명칭 보기

SFRS4, SRP75, SRSF4, Serine/arginine-rich splicing factor 4, Pre-mRNA-splicing factor SRP75, SRP001LB
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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Scientific reports 7:14503 PubMed29109428

2017

Serial-omics of P53-/-, Brca1-/- Mouse Breast Tumor and Normal Mammary Gland.

Applications

Unspecified application

Species

Unspecified reactive species

Susanne B Breitkopf,Mateus De Oliveira Taveira,Min Yuan,Gerburg M Wulf,John M Asara

Molecular reproduction and development 82:976-85 PubMed26308373

2015

Androgen receptor binding to an androgen-responsive element in the promoter of the Srsf4 gene inhibits its expression in mouse Sertoli cells.

Applications

Unspecified application

Species

Unspecified reactive species

Huan Guo,Yuchi Li,Manling Luo,Shouren Lin,Jianbo Chen,Qian Ma,Yanli Gu,Zhimao Jiang,Yaoting Gui

PloS one 7:e51497 PubMed23284704

2012

Regulation of Mcl-1 by SRSF1 and SRSF5 in cancer cells.

Applications

WB

Species

Human

Hannah L Gautrey,Alison J Tyson-Capper
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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