AB236414

Anti-SFRS9/SRSF9 antibody [OTI5G7]

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(3 제품이 사용된 논문 )

Mouse Monoclonal SFRS9/SRSF9 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SRSF9.

대체 명칭 보기

SFRS9, SRP30C, SRSF9, Serine/arginine-rich splicing factor 9, Pre-mRNA-splicing factor SRp30C

12 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS9/SRSF9 antibody [OTI5G7] (AB236414)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS9/SRSF9 antibody [OTI5G7] (AB236414)

Paraffin-embedded human lung carcinoma tissue stained for SFRS9/SRSF9 using ab236414 at 1/150 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS9/SRSF9 antibody [OTI5G7] (AB236414)

Paraffin-embedded human breast adenocarcinoma tissue stained for SFRS9/SRSF9 using ab236414 at 1/150 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS9/SRSF9 antibody [OTI5G7] (AB236414)

Paraffin-embedded human pancreas carcinoma tissue stained for SFRS9/SRSF9 using ab236414 at 1/150 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS9/SRSF9 antibody [OTI5G7] (AB236414)

Paraffin-embedded human kidney carcinoma tissue stained for SFRS9/SRSF9 using ab236414 at 1/150 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS9/SRSF9 antibody [OTI5G7] (AB236414)

Paraffin-embedded human lymph node tissue stained for SFRS9/SRSF9 using ab236414 at 1/150 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS9/SRSF9 antibody [OTI5G7] (AB236414)

Paraffin-embedded human pancreas tissue stained for SFRS9/SRSF9 using ab236414 at 1/150 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS9/SRSF9 antibody [OTI5G7] (AB236414)

Paraffin-embedded human thyroid carcinoma tissue stained for SFRS9/SRSF9 using ab236414 at 1/150 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS9/SRSF9 antibody [OTI5G7] (AB236414)

Paraffin-embedded human prostate tissue stained for SFRS9/SRSF9 using ab236414 at 1/150 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS9/SRSF9 antibody [OTI5G7] (AB236414)

Paraffin-embedded human colon adenocarcinoma tissue stained for SFRS9/SRSF9 using ab236414 at 1/150 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS9/SRSF9 antibody [OTI5G7] (AB236414)

Paraffin-embedded human kidney tissue stained for SFRS9/SRSF9 using ab236414 at 1/150 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS9/SRSF9 antibody [OTI5G7] (AB236414)

Paraffin-embedded human prostate carcinoma tissue stained for SFRS9/SRSF9 using ab236414 at 1/150 dilution in immunohistochemical analysis.

Supplier Data

Western blot - Anti-SFRS9/SRSF9 antibody [OTI5G7] (AB236414)

Lanes 1, 2 and 4:

Western blot - Anti-SFRS9/SRSF9 antibody [OTI5G7] (ab236414) at 1/500 dilution

Lane 3:

Anti-HSP90AB1

Lane 1:

Wild-type HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate at 10 µg

Lanes 2 and 4:

SFRS9/SRSF9 knockout HEK-293T whole cell lysate at 10 µg

Lane 3:

Wild-type HEK-293T whole cell lysate at 10 µg

Predicted band size: 26 kDa

false

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI5G7

Isotype

IgG2b

Carrier free

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human SRSF9.

Q13242

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/150", "IHCP-species-notes": "<p>Perform heat-induced epitope retrieval by Tris-EDTA, pH 8.0.</p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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제품 세부 정보

Clone OTI5G7 (formerly 5G7).

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification

Purification 관련 사항

Purified from cell culture supernatant.

보관 버퍼

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SFRS9 also known as SRSF9 or SRp30c is a serine/arginine-rich splicing factor critical for splicing regulation in pre-mRNA processing. Its molecular mass is approximately 28 kDa. SFRS9 is widely expressed in various tissues including the brain liver and heart. This protein belongs to the SR protein family characterized by their role in spliceosome assembly and exon selection during RNA splicing.

Biological function summary

SFRS9 contributes to the regulation of alternative splicing which increases the diversity of the proteome. It does not work alone but within the spliceosome complex where it interacts with other splicing factors. This activity helps determine which exons are included or excluded in the final mRNA affecting protein variety and cellular function. By controlling splicing events SFRS9 can influence gene expression and cellular responses to environmental cues.

Pathways

SFRS9 serves as a significant player in the RNA processing pathway. It helps modulate gene expression post-transcriptionally by governing the splicing fate of pre-mRNA transcripts. Its role intersects with pathways like the mRNA surveillance pathway where it ensures correct mRNA synthesis and processing. SFRS9's activity is also associated with other splicing factors such as SF2/ASF in regulating alternative splicing.

SFRS9 has connections to cancer and neurodegenerative disorders. Aberrations in alternative splicing patterns regulated by SFRS9 may lead to oncogenic transformations and neuronal dysfunction. In cancer its altered splicing activity can result in tumor progression. Interactions between SFRS9 and proteins involved in splicing like hnRNPs may have contributions in abnormal splicing patterns linked with these conditions.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10.

See full target information SRSF9

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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cancer biology & therapy 25:2427415 PubMed39530604

2024

A positive feedback loop of SRSF9/USP22/ZEB1 promotes the progression of ovarian cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Wang,Ming Hu,Jie Min,Xin Li

Animal bioscience 38:303-315 PubMed39210798

2024

shRNA-interfered of Nrf2 reveals a critical role for Keap1-Nrf2 signaling pathway during effects of zearalenone induced oxidative stress in IPEC-J2 cells.

Applications

Unspecified application

Species

Unspecified reactive species

Qun Cheng,Shu Zhen Jiang,Li Bo Huang,Wei Ren Yang

NAR cancer 4:zcab052 PubMed35047826

2022

Comprehensive profiling of mRNA splicing indicates that GC content signals altered cassette exon inclusion in Ewing sarcoma.

Applications

Unspecified application

Species

Unspecified reactive species

Garrett T Graham,Saravana P Selvanathan,Stefan K Zöllner,Emily Stahl,Adam Shlien,Natasha J Caplen,Aykut Üren,Jeffrey A Toretsky

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SFRS9/SRSF9 antibody [OTI5G7]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS9/SRSF9 antibody [OTI5G7] (AB236414)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS9/SRSF9 antibody [OTI5G7] (AB236414)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS9/SRSF9 antibody [OTI5G7] (AB236414)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS9/SRSF9 antibody [OTI5G7] (AB236414)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS9/SRSF9 antibody [OTI5G7] (AB236414)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS9/SRSF9 antibody [OTI5G7] (AB236414)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS9/SRSF9 antibody [OTI5G7] (AB236414)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS9/SRSF9 antibody [OTI5G7] (AB236414)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS9/SRSF9 antibody [OTI5G7] (AB236414)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS9/SRSF9 antibody [OTI5G7] (AB236414)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS9/SRSF9 antibody [OTI5G7] (AB236414)

Western blot - Anti-SFRS9/SRSF9 antibody [OTI5G7] (AB236414)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (3)

Product promise