JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB236899

Anti-SFT2D2 antibody

Be the first to review this product! 리뷰 제출

|

(1 출판물)

Rabbit Polyclonal SFT2D2 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SFT2D2 aa 1-50.

대체 명칭 보기

UNQ512/PRO1027, SFT2D2, Vesicle transport protein SFT2B, SFT2 domain-containing protein 2

1 이미지
Immunocytochemistry/ Immunofluorescence - Anti-SFT2D2 antibody (AB236899)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SFT2D2 antibody (AB236899)

MCF7 (Human breast adenocarcinoma cell line) cells stained for SFT2D2 (green) using ab236899 at 1/100 dilution in ICC/IF, followed by an Alexa-Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L).

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human SFT2D2 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

O95562

style
left-column

보완 제품

Primary Antibodies

AB47099

Anti-REG1 alpha antibody

Western blot - Anti-REG1 alpha antibody (AB47099)

  • 0
  • 0
Proteins & Peptides

AB276375

Recombinant Human REG1 protein (His tag)

SDS-PAGE - Recombinant Human REG1 protein (His tag) (AB276375)

  • 0
  • 0
Primary Antibodies

AB121236

Anti-EXD2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EXD2 antibody (AB121236)

  • 0
  • 0
Assay Kits

AB285235

Mouse Troponin I ELISA Kit

Sandwich ELISA - Mouse Troponin I ELISA Kit (AB285235)

  • 0
  • 0
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SFT2D2 also known as Suppressor of Fused (Sof1) in yeast is a protein involved in membrane trafficking and sorting within cells. It has a mass of approximately 21 kDa and is localized in the membranes of the Golgi apparatus and cytoplasmic vesicles. Expression of SFT2D2 occurs in various tissues with high levels observed in the liver and kidney. The protein possesses transmembrane domains that allow it to facilitate movement of vesicles between organelles.
Biological function summary

SFT2D2 plays a role in the Golgi apparatus' function and vesicular transport processes. It is part of a larger protein complex that helps mediate vesicle fusion and cargo transport. This protein ensures accurate sorting and delivery of proteins and lipids which are essential for maintaining cellular homeostasis. It is especially vital in regulating the processing and maturation of proteins that transit through the secretory pathway.

Pathways

SFT2D2 functions in the intracellular trafficking and secretory pathways. It interacts with the SNARE protein family to perform its role in vesicle docking and fusion. Additionally SFT2D2 has relevance in the secretory pathway where it contributes to the optimal functioning of the endoplasmic reticulum (ER) to Golgi transport. This coordination with proteins such as Syntaxin 5 ensures seamless progression of synthesized proteins to their destinations.

Alterations in SFT2D2 expression or structure might relate to metabolic dysfunctions including liver diseases. Disruption to SFT2D2 pathways also indicates a potential link to neurodegenerative disorders due to impaired vesicular trafficking. Relatedly improper association with SNARE proteins can exacerbate these conditions highlighting the importance of SFT2D2 in disease pathogenesis. Understanding its role could aid in discovering therapeutic targets in related disorders.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
See full target information SFT2D2
style
left-column

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Genome medicine 17:56 PubMed40390022

2025

Spatiotemporal single-cell analysis elucidates the cellular and molecular dynamics of human cornea aging.

Applications

Unspecified application

Species

Unspecified reactive species

Dan Jiang,Ke Li,Yining Sun,Zicheng Zhang,Shuang Xie,Xintong Yu,Ruoqi Wang,Ying Feng,Qinxiang Zheng,Yajing Wen,Peter S Reinach,Yuanyuan Du,Meng Zhou,Wei Chen
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com