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AB237804

Anti-SFXN4 antibody

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Rabbit Polyclonal SFXN4 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SFXN4.

대체 명칭 보기

BCRM1, SFXN4, Sideroflexin-4, Breast cancer resistance marker 1

3 이미지
Immunocytochemistry/ Immunofluorescence - Anti-SFXN4 antibody (AB237804)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SFXN4 antibody (AB237804)

U-251 MG (human brain glioma cell line) cells stained for SFXN4 (Green) using ab237804 at 1/100 dilution in ICC/IF, followed by Alexa Fluor® 488-congugated Goat Anti-Rabbit IgG (H+L) secondary antibody.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFXN4 antibody (AB237804)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFXN4 antibody (AB237804)

Paraffin-embedded human skeletal muscle tissue stained for SFXN4 using ab237804 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFXN4 antibody (AB237804)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFXN4 antibody (AB237804)

Paraffin-embedded human thymus tissue stained for SFXN4 using ab237804 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Recombinant Full Length Protein corresponding to Human SFXN4.

Q6P4A7

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보완 제품

Primary Antibodies

AB237811

Anti-ZNF695 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF695 antibody (AB237811)

  • 0
  • 0
Primary Antibodies

AB237623

Anti-WDFY2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-WDFY2 antibody (AB237623)

  • 0
  • 0
Primary Antibodies

AB236887

Anti-TPPP2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TPPP2 antibody (AB236887)

  • 0
  • 0
Primary Antibodies

AB237050

Anti-CBWD2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-CBWD2 antibody (AB237050)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity greater than 95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Sideroflexin 4 (SFXN4) also known as mitochondrial iron transporter SLC56A4 is part of the sideroflexin family involved with cellular iron transport within mitochondria. This protein has a molecular mass of approximately 36 kDa. Researchers often study SFXN4 due to its integral role in mitochondrial membranes where it regulates iron homeostasis. SFXN4 shows expression across various tissues with notable presence in heart skeletal muscle and pancreas indicating a widespread role in energy-demanding tissues.
Biological function summary

The SFXN4 protein participates in managing iron import into mitochondrian important for mitochondrial function and overall cellular metabolism. SFXN4 is part of a larger mitochondrial protein complex that includes sideroflexins which together ensure proper iron distribution. This function is essential in maintaining mitochondrial respiration and energy production as mitochondria require iron to produce heme and iron-sulfur clusters necessary for electron transport chain activity.

Pathways

The SFXN4 protein plays a significant role in mitochondrial iron import and homeostasis pathways. It closely interacts with proteins involved in the electron transport chain and is related to other mitochondrial transport systems. One key pathway includes the formation and maintenance of iron-sulfur clusters necessary for electron transport function where SFXN4 cooperates with other mitochondrial proteins like frataxin and ISCU which are vital for cluster assembly.

SFXN4 has implications in disorders where iron metabolism is disrupted such as sideroblastic anemia and Friedreich's ataxia. In these conditions faulty iron transport and mitochondrial iron overload contribute to pathogenesis. Relationships between SFXN4 and proteins like frataxin become important as frataxin deficiency in Friedreich's ataxia leads to impaired mitochondrial function similar to what might be seen with SFXN4 dysfunction. The links between SFXN4 and these disorders make it a potential target for therapeutic intervention and understanding mitochondrial-linked pathologies.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Mitochondrial amino-acid transporter (By similarity). Does not act as a serine transporter : not able to mediate transport of serine into mitochondria (PubMed : 30442778).
See full target information SFXN4
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell & bioscience 13:45 PubMed36879298

2023

PABPN1 regulates mRNA alternative polyadenylation to inhibit bladder cancer progression.

Applications

Unspecified application

Species

Unspecified reactive species

Liang Chen,Wei Dong,Menghao Zhou,Chenlu Yang,Ming Xiong,Gallina Kazobinka,Zhaohui Chen,Yifei Xing,Teng Hou
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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