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AB262888

Anti-SGPP1 antibody

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Rabbit Polyclonal SGPP1 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SGPP1 aa 350 to C-terminus.
2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SGPP1 antibody (AB262888)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SGPP1 antibody (AB262888)

Paraffin-embedded human kidney tissue stained for SGPP1 using ab262888 at 1/200 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SGPP1 antibody (AB262888)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SGPP1 antibody (AB262888)

Paraffin-embedded human liver tissue stained for SGPP1 using ab262888 at 1/200 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SGPP1 aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9BX95

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대체품

Primary Antibodies

AB262889

Anti-SGPP1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-SGPP1 antibody (AB262889)

  • 0
  • 0

보완 제품

Primary Antibodies

AB63856

Anti-Osteopontin antibody

BOND RX™ Validated

Immunocytochemistry/ Immunofluorescence - Anti-Osteopontin antibody (AB63856)

  • 0
  • 1
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB272570

Anti-Sphingomyelin Synthase 2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sphingomyelin Synthase 2 antibody (AB272570)

  • 0
  • 0
Primary Antibodies

AB9485

Anti-GAPDH antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-GAPDH antibody - Loading Control (AB9485)

  • 5
  • 88
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SGPP1 also known as sphingosine-1-phosphate phosphatase 1 is an enzyme that dephosphorylates sphingosine-1-phosphate (S1P) to sphingosine. This enzymatic activity helps regulate the levels of S1P a bioactive lipid involved in various cellular processes. The molecular mass of SGPP1 is approximately 50 kDa. SGPP1 is expressed in a variety of tissues including the liver brain and kidneys indicating its widespread role in the body.
Biological function summary

SGPP1 plays an important role in controlling the sphingolipid signaling pathway influencing cell growth survival and migration. It is not part of a larger complex but operates through interaction with S1P and its receptors. By removing phosphate groups from S1P SGPP1 reduces the signaling activity of this lipid mediator therefore influencing various biological responses including immune cell trafficking.

Pathways

SGPP1 functions within the sphingolipid metabolism pathway which is closely tied to the regulation of cellular processes such as proliferation and apoptosis. Its activity has a strong connection with S1P lyase which further degrades sphingosine. SGPP1 also interacts with enzymes involved in the ceramide synthesis pathway reflecting its role in balancing the levels of different sphingolipids that affect cellular functions.

SGPP1 affects conditions such as cancer and inflammation. Its ability to modulate S1P concentrations links it to tumor growth and spread as altered sphingolipid signaling can drive oncogenic processes. An additional association exists with inflammatory disorders where SGPP1 influences immune responses. SGPP1 interacts with SGPL1 another key enzyme in the sphingolipid pathway affecting these disease outcomes.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. Does not act on ceramide 1-phosphate, lysophosphatidic acid or phosphatidic acid (PubMed : 16782891). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (PubMed : 11756451, PubMed : 12815058, PubMed : 16782891). Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger (PubMed : 11756451, PubMed : 12815058, PubMed : 16782891). Involved in efficient ceramide synthesis from exogenous sphingoid bases. Converts S1P to sphingosine, which is readily metabolized to ceramide via ceramide synthase. In concert with sphingosine kinase 2 (SphK2), recycles sphingosine into ceramide through a phosphorylation/dephosphorylation cycle (By similarity). Regulates endoplasmic-to-Golgi trafficking of ceramides, resulting in the regulation of ceramide levels in the endoplasmic reticulum, preferentially long-chain ceramide species, and influences the anterograde membrane transport of both ceramide and proteins from the endoplasmic reticulum to the Golgi apparatus (PubMed : 16782891). The modulation of intracellular ceramide levels in turn regulates apoptosis (By similarity). Via S1P levels, modulates resting tone, intracellular Ca(2+) and myogenic vasoconstriction in resistance arteries (PubMed : 18583713). Also involved in unfolded protein response (UPR) and ER stress-induced autophagy via regulation of intracellular S1P levels (PubMed : 18583713, PubMed : 20798685). Involved in the regulation of epidermal homeostasis and keratinocyte differentiation (By similarity).
See full target information SGPP1

대체 명칭 보기

SPP1, SGPP1, Sphingosine-1-phosphate phosphatase 1, SPPase1, Spp1, hSPP1, hSPPase1, Sphingosine-1-phosphatase 1, Sphingosine-1-phosphate phosphohydrolase 1, SPP-1
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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