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AB96029

Anti-SGSH/HSS antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal SGSH/HSS antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SGSH aa 300-500.
2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SGSH/HSS antibody (AB96029)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SGSH/HSS antibody (AB96029)

Immunohistochemical analysis of formalin fixed paraffin embedded OVCAR3 xenograft, using ab96029 antibody at 1/100 dilution.

Western blot - Anti-SGSH/HSS antibody (AB96029)
  • WB

Unknown

Western blot - Anti-SGSH/HSS antibody (AB96029)

7.5% SDS Page

All lanes:

Western blot - Anti-SGSH/HSS antibody (ab96029) at 1/1000 dilution

All lanes:

Molt-4 whole cell lysate at 30 µg

Predicted band size: 57 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human SGSH aa 300-500. The exact immunogen used to generate this antibody is proprietary information.

P51688

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대체품

Primary Antibodies

AB72617

Anti-SGSH/HSS antibody

  • 0
  • 0
Primary Antibodies

AB200346

Anti-SGSH/HSS antibody [EPR17312]

RabMAb|Recombinant|Trial Size

Immunocytochemistry/ Immunofluorescence - Anti-SGSH/HSS antibody [EPR17312] (AB200346)

  • 4
  • 1
Primary Antibodies

AB232666

Anti-SGSH/HSS antibody [EPR17312] - BSA and Azide free

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-SGSH/HSS antibody [EPR17312] - BSA and Azide free (AB232666)

  • 0
  • 0
Primary Antibodies

AB96030

Anti-SGSH/HSS antibody

Western blot - Anti-SGSH/HSS antibody (AB96030)

  • 0
  • 0

보완 제품

Primary Antibodies

AB214671

Anti-NAGLU/NAG antibody [EPR20708]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NAGLU/NAG antibody [EPR20708] (AB214671)

  • 0
  • 0
Primary Antibodies

AB278043

Anti-LAMP1 antibody [EPR24395-31] - Lysosome Marker

BOND RX™ Validated|RabMAb|KO Validated|Recombinant|20ul selling size

Multiplex immunohistochemistry - Anti-LAMP1 antibody [EPR24395-31] - Lysosome Marker (AB278043)

  • 0
  • 0
Primary Antibodies

AB168341

Anti-Galactosidase alpha antibody [EP5828(2)]

RabMAb|Recombinant|KO Validated|20ul selling size|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Galactosidase alpha antibody [EP5828(2)] (AB168341)

  • 5
  • 2
Primary Antibodies

AB174844

Anti-ARSA/ASA antibody [EPR11039]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ARSA/ASA antibody [EPR11039] (AB174844)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The SGSH protein also known as N-sulfoglucosamine sulfohydrolase or HSS is a lysosomal enzyme with a molecular weight of approximately 56 kDa. It is primarily expressed in tissues with high turnover of glycosaminoglycans especially in the liver and brain. This enzyme localizes inside the lysosomes and plays a significant role in the degradation process of heparan sulfate. SGSH expression is important for maintaining normal cell function particularly in tissues that require constant renewal of extracellular matrix components.
Biological function summary

The enzyme acts to cleave sulfate groups from N-sulfated glucosamine residues in heparan sulfate being an important component of the degradation pathway of glycosaminoglycan. SGSH works within a lysosomal degradation complex alongside other enzymes such as iduronate-2-sulfatase and heparan-alpha-glucosaminide N-acetyltransferase each responsible for different steps in the breakdown of complex carbohydrates. Together they facilitate the complete degradation of heparan sulfate into its basic monosaccharide components.

Pathways

SGSH is integral to lysosomal degradation pathways functioning alongside proteins like alpha-L-iduronidase in the catabolic process of heparan sulfate. This breakdown pathway is essential for recycling cellular components and maintaining cellular homeostasis. The efficiencies and deficiencies in these pathways influence cellular functionality and have regulatory roles in broader metabolic circuits.

Mutations in the SGSH gene lead to Sanfilippo syndrome type IIIA also known as mucopolysaccharidosis type IIIA. This genetic disorder impairs the degradation of heparan sulfate causing an accumulation of glycosaminoglycans in cells leading to neurodegenerative conditions. In Sanfilippo syndrome type IIIA the SGSH deficiency has connections with related lysosomal storage disorders involving proteins like alpha-N-acetylglucosaminidase which further illustrate the importance of coordinated lysosomal activities.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Catalyzes a step in lysosomal heparan sulfate degradation.
See full target information SGSH

대체 명칭 보기

HSS, SGSH, N-sulphoglucosamine sulphohydrolase, Sulfoglucosamine sulfamidase, Sulphamidase
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecular therapy : the journal of the American So 23:638-47 PubMed25592334

2015

Broad functional correction of molecular impairments by systemic delivery of scAAVrh74-hSGSH gene delivery in MPS IIIA mice.

Applications

ICC/IF

Species

Unspecified reactive species

F Jason Duncan,Bartholomew J Naughton,Kimberly Zaraspe,Darren A Murrey,Aaron S Meadows,Kelly Reed Clark,David E Newsom,Peter White,Haiyan Fu,Douglas M McCarty

Molecular pharmaceutics 11:2928-34 PubMed24949884

2014

Insulin receptor antibody-sulfamidase fusion protein penetrates the primate blood-brain barrier and reduces glycosoaminoglycans in Sanfilippo type A cells.

Applications

WB

Species

Unspecified reactive species

Ruben J Boado,Jeff Zhiqiang Lu,Eric Ka-Wai Hui,William M Pardridge
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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