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AB96571

Anti-SGTA antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal SGTA antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SGTA aa 1 to C-terminus.
1 이미지
Western blot - Anti-SGTA antibody (AB96571)
  • WB

Unknown

Western blot - Anti-SGTA antibody (AB96571)

10% SDS PAGE

All lanes:

Western blot - Anti-SGTA antibody (ab96571) at 1/5000 dilution

Lane 1:

HepG2 whole cell lysate at 30 µg

Lane 2:

Molt-4 whole cell lysate at 30 µg

Predicted band size: 34 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human SGTA aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O43765

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보완 제품

Primary Antibodies

AB183734

Anti-GFP antibody [EPR14104]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFP antibody [EPR14104] (AB183734)

  • 5
  • 24
Primary Antibodies

AB22595

Anti-Calnexin antibody - ER Marker

Lab Essentials|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-Calnexin antibody - ER Marker (AB22595)

  • 5
  • 28
Primary Antibodies

AB252149

Alexa Fluor® 488 Anti-CD4 antibody [EPR20122]

RabMAb|Recombinant

Flow Cytometry - Alexa Fluor® 488 Anti-CD4 antibody [EPR20122] (AB252149)

  • 0
  • 0
Primary Antibodies

AB7291

Anti-alpha Tubulin antibody [DM1A] - Loading Control

BOND RX™ Validated

Western blot - Anti-alpha Tubulin antibody [DM1A] - Loading Control (AB7291)

  • 5
  • 92
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SGTA also known as Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha is a co-chaperone protein with a molecular mass of approximately 35 kDa. It plays a role in the protein quality control system by interacting with misfolded proteins. SGTA has a TPR domain essential for binding with other chaperones and client proteins. You can find this protein expressed in many tissues with highest levels in the liver kidney and testis.
Biological function summary

SGTA influences protein folding and degradation impacting cellular protein homeostasis. It functions as part of the chaperone system and forms complexes with Hsp70 and Hsp90 helping in stabilizing and refolding damaged proteins. SGTA's interaction with steroid hormone receptors has roles in regulating their stability and function. It also interacts with other cellular proteins indicating its diverse biological responsibilities.

Pathways

Small glutamine-rich tetratricopeptide repeat-containing protein alpha integrates into cellular mechanisms such as the ER-associated degradation (ERAD) and the ubiquitin-proteasome pathway. It associates with proteins like BAG6 which targets mislocalized proteins for degradation. It helps guide the quality control process in cells allowing the removal of faulty proteins and supporting cellular health.

SGTA shows associations with neurodegenerative diseases and certain cancers. It links to the accumulation of misfolded proteins which are common in disorders like Alzheimer's disease. In cancer SGTA's relationship with steroid hormone receptors can affect tumor growth and progression. Through pathways involving the androgen receptor SGTA potentially influences prostate cancer development.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed : 28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed : 28104892). Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed : 25535373, PubMed : 28104892). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6 : collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed : 23129660, PubMed : 25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed : 27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed : 18759457).. (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70 (PubMed : 24675744).
See full target information SGTA

대체 명칭 보기

SGT, SGT1, SGTA, Small glutamine-rich tetratricopeptide repeat-containing protein alpha, Alpha-SGT, Vpu-binding protein, UBP
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of neuroinflammation 21:29 PubMed38246987

2024

Microglia-derived exosomes modulate myelin regeneration via miR-615-5p/MYRF axis.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Yu Ji,Yu-Xin Guo,Li-Bin Wang,Wen-Cheng Wu,Jia-Qi Wang,Jin He,Rui Gao,Javad Rasouli,Meng-Yuan Gao,Zhen-Hai Wang,Dan Xiao,Wei-Feng Zhang,Bogoljub Ciric,Yuan Zhang,Xing Li

BioMed research international 2021:5545312 PubMed34285914

2021

Identification and Validation of Potential Biomarkers and Pathways for Idiopathic Pulmonary Fibrosis by Comprehensive Bioinformatics Analysis.

Applications

Unspecified application

Species

Unspecified reactive species

Weibin Qian,Xinrui Cai,Qiuhai Qian,Xinying Zhang
제품이 사용된 논문 모두 보기
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Product promise

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