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AB215055

Anti-SH2D2A/SCAP antibody

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(1 출판물)

Sheep Polyclonal SH2D2A/SCAP antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SH2D2A aa 250 to C-terminus.

대체 명칭 보기

SCAP, TSAD, VRAP, SH2D2A, SH2 domain-containing protein 2A, SH2 domain-containing adapter protein, T cell-specific adapter protein, VEGF receptor-associated protein, TSAd

1 이미지
Western blot - Anti-SH2D2A/SCAP antibody (AB215055)
  • WB

Supplier Data

Western blot - Anti-SH2D2A/SCAP antibody (AB215055)

All lanes:

Western blot - Anti-SH2D2A/SCAP antibody (ab215055) at 1/1000 dilution

All lanes:

mouse bone marrow lysate

Predicted band size: 43 kDa

Observed band size: 46 kDa

false

주요 정보

Host species

Sheep

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human SH2D2A aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9NP31

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보완 제품

Primary Antibodies

AB308060

Anti-SCAP antibody [EPR26242-60]

20ul selling size|RabMAb|Recombinant

Western blot - Anti-SCAP antibody [EPR26242-60] (AB308060)

  • 0
  • 0
Primary Antibodies

AB172730

Rabbit IgG, monoclonal [EPR25A] - Isotype Control

RabMAb|Advanced Validation|Recombinant

Flow Cytometry - Rabbit IgG, monoclonal [EPR25A] - Isotype Control (AB172730)

  • 0
  • 0
Primary Antibodies

AB191387

Anti-KDM2A antibody [EPR18602]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-KDM2A antibody [EPR18602] (AB191387)

  • 4
  • 1
Primary Antibodies

AB52757

Anti-HSF1 antibody [EP1710Y] - ChIP Grade

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-HSF1 antibody [EP1710Y] - ChIP Grade (AB52757)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Lyophilized
Reconstitution
reconstitute with PBS at 500µg/mL
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
The IgG fraction of immunized serum was purified by antigen affinity chromatography and lyophilized from a 0.2 µm filtered solution in phosphate-buffered saline (PBS)
보관 버퍼
Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SH2D2A also known as SCAP is an adapter protein of around 41 kDa mass with a central role in signaling pathways. It contains an SH2 domain that allows it to interact with specific phosphorylated tyrosine residues on other proteins. It has expression mainly in immune cells such as T lymphocytes. It functions by connecting receptors on the cell surface to downstream signaling molecules inside the cell. This makes SH2D2A an important player in transmitting extracellular signals to the cell interior.
Biological function summary

Interactions of SH2D2A affect immune cell activation and differentiation progressing to modulate immune responses. It is not part of a larger complex; instead it acts independently to amplify cellular responses. SH2D2A influences signaling pathways that involve cytokines and other immune modulators regulating the magnitude and direction of cellular activities in the immune system.

Pathways

SH2D2A plays a role in the T-cell receptor signaling and calcium signaling pathways. In the T-cell receptor signaling pathway it interacts with proteins like Lck and ZAP-70 aiding in the activation cascade that leads to T-cell activation. In the calcium signaling pathway SH2D2A can connect to phospholipase C-gamma which ultimately affects intracellular calcium levels and further communication within immune responses.

SH2D2A has associations with autoimmune diseases and immune deficiencies. Its misregulation in autoimmune diseases leads to an inappropriate immune response and tissue damage. Autoimmune disorders such as rheumatoid arthritis have links to SH2D2A due to its interactions with proteins like LAT which participate in overactive immune signaling. In immune deficiencies malfunctioning SH2D2A can result in insufficient immune response making understanding this target essential for therapeutic exploration.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation.
See full target information SH2D2A
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Anatomical record (Hoboken, N.J. : 2007) 302:1587-1593 PubMed30471213

2018

AIP1 Suppresses Transplant Arteriosclerosis Through Inhibition of Vascular Smooth Muscle Cell Inflammatory Response to IFNγ.

Applications

Unspecified application

Species

Unspecified reactive species

Lingfeng Qin,Wang Min,Shijie Xin
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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