JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB235352

Anti-SH3GLB2 antibody

Be the first to review this product! 리뷰 제출

|

(1 출판물)

Rabbit Polyclonal SH3GLB2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SH3GLB2 aa 1-400.

대체 명칭 보기

KIAA1848, PP578, SH3GLB2, Endophilin-B2, SH3 domain-containing GRB2-like protein B2

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3GLB2 antibody (AB235352)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3GLB2 antibody (AB235352)

Paraffin-embedded human placenta tissue stained for SPS2L/SPATS2L using ab235352 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human SH3GLB2 aa 1-400. The exact immunogen used to generate this antibody is proprietary information.

Q9NR46

style
left-column

보완 제품

Primary Antibodies

AB121977

Anti-srGAP2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-srGAP2 antibody (AB121977)

  • 4
  • 2
Primary Antibodies

AB154236

Anti-Bif-1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-Bif-1 antibody (AB154236)

  • 0
  • 0
Primary Antibodies

AB171938

Anti-SRGAP1 antibody [EPR8760(2)]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-SRGAP1 antibody [EPR8760(2)] (AB171938)

  • 0
  • 0
Primary Antibodies

AB97512

Anti-Villin antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Villin antibody (AB97512)

  • 4
  • 1
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SH3GLB2 also known as Bin1 or Amphiphysin II is a protein involved in membrane dynamics and intracellular trafficking. It has a molecular weight of approximately 40 kDa and is expressed in various tissues with significant expression in the brain heart and skeletal muscle. The protein contains a SH3 domain enabling it to interact with proline-rich motifs of partner proteins. This feature supports its role in processes involving membrane curvature and endocytosis.
Biological function summary

SH3GLB2 participates in the regulation of membrane remodeling. It acts as part of a larger complex that influences synaptic vesicle endocytosis by facilitating the scission of vesicles from the plasma membrane. This function is critical for maintaining cellular communication and signaling particularly in neuronal cells where rapid membrane trafficking is required. SH3GLB2's interactions allow for dynamic responses to cellular stress and help in maintaining cellular homeostasis.

Pathways

This protein is implicated in both the endocytic pathway and apoptotic processes. SH3GLB2 orchestrates interactions within the endocytic pathway alongside proteins such as clathrin and dynamin where it aids in vesicle formation and trafficking. Furthermore it contributes to the apoptotic pathway by modulating factors that influence cell survival and death interacting with proteins like Bax which plays a role in apoptosis regulation. These pathways highlight its involvement in maintaining cellular order and response to external stimuli.

Abnormalities in SH3GLB2 function have been linked to neurodegenerative diseases and certain cancers. In neurodegenerative diseases disrupted SH3GLB2 activity affects synaptic function and neuronal communication potentially contributing to conditions like Alzheimer's disease. Perturbations in SH3GLB2 interactions with proteins such as tau are noticeable in such disorders. In cancers altered expression or mutation of SH3GLB2 can influence cellular proliferation and invasion mainly through its impact on the endocytic and apoptotic pathways. This connection suggests its role as a potential biomarker or target for therapeutic interventions.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

See full target information SH3GLB2
style
left-column

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

The Journal of clinical endocrinology and metabolism 107:3328-3340 PubMed36074910

2022

Premature Ovarian Insufficiency in CLPB Deficiency: Transcriptomic, Proteomic and Phenotypic Insights.

Applications

Unspecified application

Species

Unspecified reactive species

Elena J Tucker,Megan J Baker,Daniella H Hock,Julia T Warren,Sylvie Jaillard,Katrina M Bell,Rajini Sreenivasan,Shabnam Bakhshalizadeh,Chloe A Hanna,Nikeisha J Caruana,Saskia B Wortmann,Shamima Rahman,Robert D S Pitceathly,Jean Donadieu,Aurelia Alimi,Vincent Launay,Paul Coppo,Sophie Christin-Maitre,Gorjana Robevska,Jocelyn van den Bergen,Brianna L Kline,Katie L Ayers,Phoebe N Stewart,David A Stroud,Diana Stojanovski,Andrew H Sinclair
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com