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AB237630

Anti-SLC19A3 antibody

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(1 출판물)

Rabbit Polyclonal SLC19A3 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLC19A3 aa 150-300.

대체 명칭 보기

Thiamine transporter 2, ThTr-2, ThTr2, Solute carrier family 19 member 3, SLC19A3

1 이미지
Immunocytochemistry/ Immunofluorescence - Anti-SLC19A3 antibody (AB237630)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SLC19A3 antibody (AB237630)

4% formaldehyde-fixed, 0.2% Triton X-100 permeabilized HepG2 (human liver hepatocellular carcinoma cell line) cells stained for SLC19A3 (green) using ab237630 at 1/166 dilution in ICC/IF, followed by Alexa Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L). Counter-stained with DAPI.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human SLC19A3 aa 150-300. The exact immunogen used to generate this antibody is proprietary information.

Q9BZV2

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보완 제품

Primary Antibodies

AB307399

Alexa Fluor® 488 Anti-CD105 antibody [EPR22811-18]

RabMAb|Recombinant

Flow Cytometry - Alexa Fluor® 488 Anti-CD105 antibody [EPR22811-18] (AB307399)

  • 0
  • 0
Primary Antibodies

AB318177

Alexa Fluor® 568 Anti-CD73 antibody [EPR28213-52]

Recombinant|RabMAb|KO Validated

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 568 Anti-CD73 antibody [EPR28213-52] (AB318177)

  • 0
  • 0
Primary Antibodies

AB195013

Alexa Fluor® 488 Anti-CD34 antibody [EP373Y]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Alexa Fluor® 488 Anti-CD34 antibody [EP373Y] (AB195013)

  • 5
  • 5
Primary Antibodies

AB229680

Anti-TC1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-TC1 antibody (AB229680)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Cynomolgus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity greater than 95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The SLC19A3 protein also known as thiamine transporter 2 is involved in the transport of thiamine across cell membranes. This protein consists of approximately 496 amino acids and its molecular mass is about 54 kDa. SLC19A3 is expressed in various tissues with higher levels found in the liver brain and kidneys. The protein functions to facilitate the uptake of thiamine a critical vitamin B1 into cells where it is necessary for proper cellular metabolism.
Biological function summary

Thiamine transporter 2 participates in the management of thiamine homeostasis ensuring cells receive adequate nutrients to meet metabolic demands. SLC19A3 forms part of a complex with other transporter proteins that contribute to the maintenance of cellular thiamine levels. This protein's activity is important in tissues with high metabolic rates supporting the production of ATP through involvement in metabolic pathways requiring thiamine-based cofactors.

Pathways

The SLC19A3 protein is integral to both the energy metabolism and the thiamine metabolism pathways. It plays a role in converting thiamine into its active form thiamine pyrophosphate which is necessary for the function of enzymes like pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase. These enzymes are involved in the citric acid cycle highlighting the importance of SLC19A3 in energy production. Its activity is related to other proteins such as SLC19A2 which also facilitates thiamine transport within similar pathways.

Impaired function of the SLC19A3 protein is linked to thiamine metabolism dysfunction syndrome 2 (THMD2) and biotin-thiamine-responsive basal ganglia disease. These diseases result from mutations disrupting thiamine transport leading to neurological and metabolic complications. SLC19A3 disruptions also align with changes in L-type calcium channel subunits indicating a broader network of nutrient transport and ion channel regulation in maintaining cellular health.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism (PubMed : 11731220, PubMed : 33008889, PubMed : 35512554, PubMed : 35724964). Has no folate transport activity (PubMed : 11731220). Mediates H(+)-dependent pyridoxine transport (PubMed : 33008889, PubMed : 35512554, PubMed : 35724964, PubMed : 36456177).
See full target information SLC19A3
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecular and cellular biochemistry 477:649-661 PubMed34870753

2021

MiR-1246 regulates the PI3K/AKT signaling pathway by targeting PIK3AP1 and inhibits thyroid cancer cell proliferation and tumor growth.

Applications

Unspecified application

Species

Unspecified reactive species

Jingyan Li,Zhanlei Zhang,Jieting Hu,Xiaoting Wan,Wei Huang,Hong Zhang,Ningyi Jiang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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