AB237527

Anti-SLC20A1 antibody

(1 리뷰)

(6 제품이 사용된 논문 )

Rabbit Polyclonal SLC20A1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLC20A1 aa 250-500.

대체 명칭 보기

GLVR1, PIT1, SLC20A1, Sodium-dependent phosphate transporter 1, Gibbon ape leukemia virus receptor 1, Leukemia virus receptor 1 homolog, Phosphate transporter 1, Solute carrier family 20 member 1, GLVR-1, PiT-1

3 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC20A1 antibody (AB237527)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC20A1 antibody (AB237527)

Paraffin-embedded human ovarian cancer tissue stained for SLC20A1 with ab237527 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC20A1 antibody (AB237527)

Paraffin-embedded human liver tissue stained for SLC20A1 with ab237527 at a 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-SLC20A1 antibody (AB237527)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SLC20A1 antibody (AB237527)

HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for SLC20A1 (green) using ab237527 at 1/100 dilution in ICC/IF. Secondary used is an Alexa-Fluor^®488-conjugated Goat Anti-Rabbit IgG (H+L).

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

ICC/IF, WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SLC20A1 aa 250-500. The exact immunogen used to generate this antibody is proprietary information.

Q8WUM9

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "" }, "Cat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein G

Purification 관련 사항

Purity greater than 95%

보관 버퍼

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SLC20A1 also known as PiT-1 is a type III sodium-dependent phosphate transporter with a molecular mass of approximately 75 kDa. It helps in the uptake of inorganic phosphate into cells using sodium as a co-transport mechanism. This transport is essential for maintaining phosphate homeostasis within the body. SLC20A1 is expressed in various tissues including the liver kidney lung and cardiac tissues indicating its broad role in bodily functions.

Biological function summary

The expression of SLC20A1 plays a role in phosphate metabolism contributing to bone mineralization and cellular energy transfer. It exists as part of a complex that regulates phosphate uptake alongside its relative SLC20A2. The protein is key to cellular proliferation and survival and it influences processes like cell signaling and metabolism through its transport activity.

Pathways

Phosphate modulation by SLC20A1 interacts with cellular pathways involving calcium signaling and energy production. It is also associated with the mTOR pathway which controls cell growth and proliferation. Alongside proteins like PiT-2 SLC20A1 regulates phosphate balance which is essential for proper cellular function linking it to broader metabolic pathways.

Mutations or dysregulation of the SLC20A1 gene connect to conditions such as familial idiopathic basal ganglia calcification and hyperphosphatemia. These conditions often involve abnormal phosphate deposition in body tissues. Abnormal interactions with proteins like SCL20A2 might lead to defective phosphate uptake resulting in disease manifestations affecting neurological and renal functions.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed : 11009570, PubMed : 16790504, PubMed : 17494632, PubMed : 19726692, PubMed : 7929240, PubMed : 8041748). May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification (PubMed : 11009570). Essential for cell proliferation but this function is independent of its phosphate transporter activity (PubMed : 19726692).. (Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV).

See full target information SLC20A1

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제품이 사용된 논문 (6)

Recent publications for all applications. Explore the 전체 목록 and refine your search

International journal of molecular sciences 25: PubMed39063137

2024

Host Cells Upregulate Phosphate Transporter PIT1 to Inhibit Intracellular Growth.

Applications

Unspecified application

Species

Unspecified reactive species

Meifang Li,Nan Yang,Xiaoxiao Li,Nan Duan,Shanhua Qin,Mengyao Wang,Yuhong Zhou,Yongxin Jin,Weihui Wu,Shouguang Jin,Zhihui Cheng

Journal of Cancer 15:2260-2275 PubMed38495502

2024

Development and Validation of the novel Cuproptosis- and Immune-related Signature for Predicting Prognosis in Hepatocellular Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yongping Zhang,Ping Sui,Cheng Zhong,Jiansheng Liu

International journal of molecular sciences 24: PubMed38139044

2023

Phosphate (Pi) Transporter PIT1 Induces Pi Starvation in -Containing Vacuole in HeLa Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Wen Yang,Yingxing Feng,Jun Yan,Chenbo Kang,Ting Yao,Hongmin Sun,Zhihui Cheng

Cell reports 39:110698 PubMed35443182

2022

Bladder epithelial cell phosphate transporter inhibition protects mice against uropathogenic Escherichia coli infection.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Pang,Zhihui Cheng,Si Zhang,Shujie Li,Xueping Li,Xiaodan Li,Xiao Zhang,Xiaoxiao Li,Yingxing Feng,Heting Cui,Zhen Chen,Le Liu,Qing Li,Jianxiao Huang,Mingqing Zhang,Siwei Zhu,Lei Wang,Lu Feng

Acta biomaterialia 130:485-496 PubMed34129957

2021

Effects of nanocrystalline hydroxyapatite concentration and skeletal site on bone and cartilage formation in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Lauren A Boller,Stefanie M Shiels,David C Florian,Sun H Peck,Jonathan G Schoenecker,Craig Duvall,Joseph C Wenke,Scott A Guelcher

Molecular medicine reports 20:3276-3284 PubMed31432167

2019

Impact of SLC20A1 on the Wnt/β‑catenin signaling pathway in somatotroph adenomas.

Applications

Unspecified application

Species

Unspecified reactive species

Jianhua Li,Wei Dong,Zhenye Li,Hongyun Wang,Hua Gao,Yazhuo Zhang

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SLC20A1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC20A1 antibody (AB237527)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC20A1 antibody (AB237527)

Immunocytochemistry/ Immunofluorescence - Anti-SLC20A1 antibody (AB237527)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (6)

Product promise