AB230890

Anti-SLC6A15 antibody - N-terminal

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Rabbit Polyclonal SLC6A15 antibody. N-terminal. Suitable for IHC-P, WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SLC6A15 conjugated to Keyhole Limpet Haemocyanin.

대체 명칭 보기

B0AT2, NTT73, SBAT1, SLC6A15, Sodium-dependent neutral amino acid transporter B(0)AT2, Sodium- and chloride-dependent neurotransmitter transporter NTT73, Sodium-coupled branched-chain amino-acid transporter 1, Solute carrier family 6 member 15, Transporter v7-3

2 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC6A15 antibody - N-terminal (AB230890)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC6A15 antibody - N-terminal (AB230890)

Formalin-fixed, paraffin-embedded human brain cortex tissue stained for SLC6A15 with ab230890 at a 1/100 dilution in immunohistochemical analysis.

Supplier Data

Western blot - Anti-SLC6A15 antibody - N-terminal (AB230890)

All lanes:

Western blot - Anti-SLC6A15 antibody - N-terminal (ab230890) at 1/500 dilution

Lane 1:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate

Lane 2:

Mouse brain whole cell lysate

Lane 3:

Rat brain whole cell lysate

Predicted band size: 82 kDa

true

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat, Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human SLC6A15 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q9H2J7

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": " Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "" }, "Mouse": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.3 Preservative: 0.01% Sodium azide Constituents: PBS, 30% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SLC6A15 also known as sodium-dependent amino acid transporter B(0)AT2 is a protein involved in the transport of amino acids across cellular membranes in a sodium-dependent manner. This protein's mass is approximately 73 kDa. It is expressed mostly in the brain kidney and small intestine where it plays an important role in maintaining amino acid homeostasis within cells.

Biological function summary

The transporter plays a significant role in neurotransmitter regulation by facilitating the uptake of neutral amino acids which serve as precursors for neurotransmitter synthesis. It is not known to be part of a larger complex which allows it functional specificity in the transport processes it mediates. The protein's activity impacts neurological functions and metabolic processes through its influence on amino acid availability.

Pathways

SLC6A15 significantly contributes to amino acid transport pathways particularly those critical for the central nervous system's function. This transporter interacts closely with proteins such as B0AT1 which also participates in similar transport activities. The pathways that incorporate SLC6A15 contribute to maintaining the balance of amino acids in the brain which are necessary for cognitive processes and metabolism.

SLC6A15's dysregulation has been associated with major depressive disorder and obesity. This link may be due to its vital role in amino acid supply for neurotransmitter production and metabolic regulation. Proteins such as serotonin transporter (SERT) might be affected due to alterations in amino acid availability impacting mood and metabolic balance. Understanding this protein's function in these conditions could offer insights into new therapeutic strategies.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Can also transport low-affinity substrates such as alanine, phenylalanine, glutamine and pipecolic acid. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1 : 1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent.

See full target information SLC6A15

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Human reproduction (Oxford, England) 40:119-137 PubMed39521729

2024

Upregulated let-7 expression in the follicular fluid of patients with endometriomas leads to dysfunction of granulosa cells through targeting of IGF1R.

Applications

Unspecified application

Species

Unspecified reactive species

Libing Shi,Hanqi Ying,Yongdong Dai,Yan Rong,Jianmin Chen,Feng Zhou,Shasha Wang,Shiqian Xu,Xiaomei Tong,Songying Zhang

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SLC6A15 antibody - N-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC6A15 antibody - N-terminal (AB230890)

Western blot - Anti-SLC6A15 antibody - N-terminal (AB230890)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (1)

Product promise