AB236669

Anti-SLC7A7 antibody

Name: Anti-SLC7A7 antibody
Brand: Abcam Limited
SKU: AB236669
Rating: 5 (1 reviews)

(1 리뷰)

(3 제품이 사용된 논문 )

Rabbit Polyclonal SLC7A7 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLC7A7 aa 300-400.

대체 명칭 보기

Y+L amino acid transporter 1, Monocyte amino acid permease 2, Solute carrier family 7 member 7, y(+)L-type amino acid transporter 1, MOP-2, Y+LAT1, y+LAT-1, SLC7A7

3 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC7A7 antibody (AB236669)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC7A7 antibody (AB236669)

Paraffin-embedded human pancreas tissue stained for SLC7A7 using ab236669 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC7A7 antibody (AB236669)

Paraffin-embedded human kidney tissue stained for SLC7A7 using ab236669 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-SLC7A7 antibody (AB236669)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SLC7A7 antibody (AB236669)

HepG2 (human liver hepatocellular carcinoma cell line) cells labeling SLC7A7 using ab236669 at 1/100 dilution in ICC/IF analysis. Alexa Fluor^® 488-congugated Goat Anti-Rabbit IgG (H+L) was used as the secondary antibody.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human SLC7A7 aa 300-400. The exact immunogen used to generate this antibody is proprietary information.

Q9UM01

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein G

Purification 관련 사항

Purity >95%

보관 버퍼

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SLC7A7 also known as LAT1 or Lysinuric Protein Intolerance Protein is a component of the heterodimeric amino acid transporter complex. It weighs approximately 60 kDa. This protein functions mechanically by being part of a sodium-independent transporter system that facilitates the cellular import and export of essential amino acids particularly lysine arginine and ornithine. SLC7A7 mainly exhibits its expression in epithelial cells of the kidney and intestine as well as in the placenta and leukocytes reflecting its role in amino acid transport critical for cellular metabolism.

Biological function summary

This transporter protein plays an important role in balancing intracellular and extracellular concentrations of specific amino acids which are fundamental building blocks for protein synthesis and precursors for various metabolic processes. SLC7A7 forms a complex with a partner protein SLC3A2 to form a functional transporter. This complex localizes in cell membranes and actively participates in maintaining amino acid homeostasis which is essential for cell growth tissue repair and immune function.

Pathways

SLC7A7 is integral in the amino acid transport and metabolism pathways. It contributes to the mammalian target of rapamycin (mTOR) signaling pathway which regulates cell growth based on nutrient availability including amino acids. In this pathway it interacts with related proteins such as mTOR enabling cellular responses to nutrient levels. Additionally the SLC7A7 transporter is involved in the urea cycle and nitric oxide synthesis through its impact on arginine transport linking it to these metabolic processes.

SLC7A7 is strongly associated with Lysinuric Protein Intolerance (LPI) a rare autosomal recessive disorder characterized by poor absorption and excretion of cationic amino acids leading to growth retardation and immune dysfunction. The deficiency in functioning SLC7A7 disrupts normal amino acid transport which affects nutritional status and overall health. SLC7A7's involvement is also noted in systemic disorders related to mTOR pathway dysregulation linking it to conditions like certain metabolic syndromes. In the context of these disorders its interaction with SLC3A2 remains a point of significant consideration.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids from inside the cells in exchange with neutral amino acids plus sodium ions and may participate in nitric oxide synthesis via the transport of L-arginine (PubMed : 10080182, PubMed : 10655553, PubMed : 14603368, PubMed : 15756301, PubMed : 15776427, PubMed : 17329401, PubMed : 9829974, PubMed : 9878049). Also mediates arginine transport in non-polarized cells, such as monocytes, and is essential for the correct function of these cells (PubMed : 15280038, PubMed : 31705628). The transport mechanism is electroneutral and operates with a stoichiometry of 1 : 1 (By similarity). In vitro, Na(+) and Li(+), but also H(+), are cotransported with the neutral amino acids (By similarity).

See full target information SLC7A7

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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Frontiers in oncology 15:1531420 PubMed40519291

2025

Metformin inhibits the proliferation of hepatocellular carcinoma cells through inducing ferroptosis analyzed by phosphoproteomics.

Applications

Unspecified application

Species

Unspecified reactive species

Jihan Sun,Xi Yu,Yuying Shan,Manyun Dai,Andrea Gaucherot,Caide Lu,Shuqi Mao

Stem cell research & therapy 15:492 PubMed39707501

2024

FDFT1 maintains glioblastoma stem cells through activation of the Akt pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Hui Mo,Jiajia Shao,Zhun Li,Peiting Zeng,Xinke Yin,Yongsheng Huang,Peng Wang,Jianwei Liao

Frontiers in oncology 12:934080 PubMed36119478

2022

Comprehensive analysis of fatty acid and lactate metabolism-related genes for prognosis value, immune infiltration, and therapy in osteosarcoma patients.

Applications

Unspecified application

Species

Unspecified reactive species

Zhouwei Wu,Tao Han,Haohan Su,Jiangwei Xuan,Xinwei Wang

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SLC7A7 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC7A7 antibody (AB236669)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC7A7 antibody (AB236669)

Immunocytochemistry/ Immunofluorescence - Anti-SLC7A7 antibody (AB236669)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (3)

Product promise