AB243383

Anti-SLMAP antibody

Be the first to review this product! 리뷰 제출

(1 출판물)

Rabbit Polyclonal SLMAP antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLMAP aa 1-150.

대체 명칭 보기

KIAA1601, SLAP, UNQ1847/PRO3577, SLMAP, Sarcolemmal membrane-associated protein, Sarcolemmal-associated protein

6 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLMAP antibody (AB243383)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLMAP antibody (AB243383)

Formalin-fixed, paraffin-embedded human smooth muscle tissue stained for SLMAP with ab243383 at a 1 : 200 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-SLMAP antibody (AB243383)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SLMAP antibody (AB243383)

Immunocytochemistry/Immunofluorescence analysis of A431 (Human epidermoid carcinoma cell line) cells labeling SLMAP using ab243383 at 4 μg/ml (green). Nuclear probe is visualized in blue, microtubules in red.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLMAP antibody (AB243383)

Formalin-fixed, paraffin-embedded human testis tissue stained for SLMAP with ab243383 at a 1 : 200 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLMAP antibody (AB243383)

Formalin-fixed, paraffin-embedded human liver tissue stained for SLMAP with ab243383 at a 1 : 200 dilution in immunohistochemical analysis.

Supplier Data

Western blot - Anti-SLMAP antibody (AB243383)

All lanes:

Western blot - Anti-SLMAP antibody (ab243383) at 0.4 µg/mL

Lane 1:

RT4 (Human urinary bladder cancer cell line) cell lysate

Lane 2:

U-251 MG (Human brain glioma cell line) cell lysate

Lane 3:

A431 (Human epidermoid carcinoma cell line) cell lysate

Lane 4:

Human liver lysate

Lane 5:

Human tonsil lysate

Predicted band size: 95 kDa

false

Supplier Data

Western blot - Anti-SLMAP antibody (AB243383)

All lanes:

Western blot - Anti-SLMAP antibody (ab243383) at 0.4 µg/mL

Lane 1:

NIH/3T3 (Mouse embryo fibroblast cell line) cell lysate

Lane 2:

NBT-II (Rat Wistar bladder tumor cell line) cell lysate

Predicted band size: 95 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat, Human

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human SLMAP aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q14BN4

style

left-column

style

left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": " Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "Fixation/Permeabilization: PFA/Triton X-100." }, "Mouse": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

style

left-column

style

left-column

특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

style

left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SLMAP also known as sarcolemmal membrane-associated protein is a protein of approximately 91 kDa in size. It plays a role in maintaining structure and stability in cells particularly in muscle tissues. The protein localizes primarily to membranes of the sarcolemma a structure associated with muscle cells. Although present in various tissues it shows higher expression within cardiac and skeletal muscles indicating its importance in these areas.

Biological function summary

SLMAP is involved in the organization of the cytoskeletal structure in muscular tissues. It interacts with ion channels and other membrane proteins forming part of a larger complex that stabilizes cellular membranes during muscle contraction and relaxation. SLMAP assists in modulating the activities of these channels impacting cellular excitability and signal transduction. Its role is critical for the integrity of muscle function ensuring proper mechanical and electrical responses in muscle fibers.

Pathways

SLMAP plays a role in the cellular signaling processes important for cardiac muscle homeostasis. It participates in the regulation of ion transport pathways interacting closely with proteins such as ion channel subunits. SLMAP is also associated with muscle contraction pathways where it impacts signaling mechanisms that coordinate muscle function. These interactions highlight its importance in pathways that ensure the efficient functioning of muscle tissues.

Problems with SLMAP expression or function relate to cardiac disorders including cardiomyopathy and arrhythmias. These conditions can stem from disruptions in cardiac ion channel functions a process in which SLMAP plays a critical role. Additionally abnormal SLMAP function may connect to muscular dystrophies where it is part of a network of proteins involving dystrophin that supports muscle integrity. These associations underline SLMAP’s involvement in maintaining muscle health suggesting its potential as a target for therapeutic intervention in relevant diseases.

style

left-column

style

left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

타겟 정보

Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1 : SLMAP)STRIPAK complex (PubMed : 29063833, PubMed : 30622739). The (SIKE1 : SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth (PubMed : 29063833, PubMed : 30622739). May play a role during myoblast fusion (By similarity).

See full target information SLMAP

style

left-column

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cancer medicine 12:10738-10754 PubMed36880364

2023

Sulfotransferase 1C2 promotes hepatocellular carcinoma progression by enhancing glycolysis and fatty acid metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Liya Jiang,Fang Xu,Chenglong Li,Ting Liu,Qianwei Zhao,Yixian Liu,Ying Zhao,Yamei Li,Zhendong Zhang,Xiaolei Tang,Jintao Zhang

제품이 사용된 논문 모두 보기

style

left-column

style

left-column

style

right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SLMAP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLMAP antibody (AB243383)

Immunocytochemistry/ Immunofluorescence - Anti-SLMAP antibody (AB243383)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLMAP antibody (AB243383)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLMAP antibody (AB243383)

Western blot - Anti-SLMAP antibody (AB243383)

Western blot - Anti-SLMAP antibody (AB243383)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (1)

Product promise