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AB101402

Anti-Sohlh2 antibody

1

(1 리뷰)

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(3 제품이 사용된 논문 )

Rabbit Polyclonal Sohlh2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SOHLH2 aa 1 to C-terminus.

대체 명칭 보기

TEB1, SOHLH2, Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sohlh2 antibody (AB101402)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sohlh2 antibody (AB101402)

Immunohistochemical analysis of paraffin embedded Ca922 xenograft, using ab101402 at a 1/500 dilution.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SOHLH2 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9NX45

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보완 제품

Primary Antibodies

AB308124

Anti-Stra8 antibody [EPR27083-56]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|Trial Size

Immunohistochemistry - Anti-Stra8 antibody [EPR27083-56] (AB308124)

  • 0
  • 0
Primary Antibodies

AB305064

Anti-Plzf antibody [EPR24830-8]

20ul selling size|RabMAb|Recombinant

Western blot - Anti-Plzf antibody [EPR24830-8] (AB305064)

  • 0
  • 0
Primary Antibodies

AB314313

Anti-SCP3 antibody [EPR27086-101]

20ul selling size|RabMAb|Recombinant|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCP3 antibody [EPR27086-101] (AB314313)

  • 0
  • 0
Primary Antibodies

AB82527

Anti-GCNA1 antibody [TRA98]

Immunohistochemistry (Frozen sections) - Anti-GCNA1 antibody [TRA98] (AB82527)

  • 5
  • 5
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p>Suggested antigen retrieval: use heat mediated 10 mM Citrate buffer or Tris EDTA buffer (pH8.0).</p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Sohlh2 also known as Spermatogenesis and Oogenesis-specific basic Helix-Loop-Helix 2 is a transcription factor with a molecular mass of about 32 kDa. It is expressed in reproductive tissues notably in the ovaries and testes. Sohlh2 plays a mechanical role by binding to specific DNA sequences regulating the expression of genes essential for germ cell development. This protein influences the differentiation and function of cells critical for reproduction.
Biological function summary

Sohlh2 influences germline specification and is key for both oogenesis and spermatogenesis. By ensuring the proper expression of specific target genes it plays a pivotal role in reproductive organ development. Sohlh2 could form complexes with other transcription factors although further research may be needed to define such interactions comprehensively. The regulation and presence of Sohlh2 ensure that germ cells undergo proper development and maturation.

Pathways

Sohlh2 is integrated into reproductive pathways that regulate germ cell differentiation. It interacts through pathways involving gene expression and cellular differentiation. Proteins like Figla and Nobox also participate in these reproductive processes and together with Sohlh2 they orchestrate the development of gametes. These interactions are integral for maintaining fertility and proper reproductive system function.

Sohlh2 has implications in fertility issues and gonadal dysgenesis. Altered expression or mutations in Sohlh2 can contribute to conditions like premature ovarian failure or azoospermia. Disorders involving reproductive development may reflect dysregulation of related proteins such as Lhx8 which works alongside Sohlh2 in the same biological processes. Understanding these interactions and pathways is fundamental for potential therapeutic strategies in treating related fertility disorders.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermatogonial stem cells maintenance, and induces genes important for spermatogonial differentiation. Coordinates oocyte differentiation without affecting meiosis I (By similarity).
See full target information SOHLH2
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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Oncotarget 7:49411-49424 PubMed27384482

2016

Sohlh2 suppresses epithelial to mesenchymal transition in breast cancer via downregulation of IL-8.

Applications

Unspecified application

Species

Unspecified reactive species

Shufang Ji,Wenfang Zhang,Xiaoli Zhang,Chunyan Hao,Aijun Hao,Qing Gao,Hongying Zhang,Jinhao Sun,Jing Hao

Molecular carcinogenesis 55:1127-37 PubMed26153894

2015

Sohlh2 inhibits human ovarian cancer cell invasion and metastasis by transcriptional inactivation of MMP9.

Applications

Unspecified application

Species

Unspecified reactive species

Haiyu Zhang,Chunyan Hao,Yang Wang,Shufang Ji,Xiaoli Zhang,Wenfang Zhang,Qinghao Zhao,Jinhao Sun,Jing Hao

Carcinogenesis 35:1863-71 PubMed24858206

2014

Sohlh2 inhibits ovarian cancer cell proliferation by upregulation of p21 and downregulation of cyclin D1.

Applications

Unspecified application

Species

Unspecified reactive species

Haiyu Zhang,Xiaoli Zhang,Shufang Ji,Chunyan Hao,Yulan Mu,Jinhao Sun,Jing Hao
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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